Lactobacillus for ribosome peptide editing cancer

Abstract

This study reviews newly discovered insect peptide point mutations as new possible cancer research targets. To interpret newly discovered peptide point mutations in insects as new possible cancer research targets, we focused on the numerous peptide changes found in the ‘CSP’ family on the sex pheromone gland of the female silkworm moth Bombyx mori . We predict that the Bombyx peptide modifications will have a significant effect on cancer CUP (cancers of unknown primary) therapy and that bacterial peptide editing techniques, specifically Lactobacillus combined to CRISPR, will be used to regulate ribosomes and treat cancer in humans.

3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats

“…Our 3L bioproduct could pave the way for the development of a large family of pharmacologically therapeutic microbial bioproducts that would be used on cancer patients rather than chemo-animal models. We begin the comprehensive strategy to control the microbiome and ribosomes and treat human cancer with 3L [162].…”

Renaming ‘Chemosensory’ Proteins (CSPs): Lipid/Nucleotide-Binding Proteins — Molecular Nomenclature, Structure, Expression, Function, Evolutionary Networks, Clinical Diseases and Associated Molecular Medicine

“…Because of the CSP structure's extreme flexibility, multifunctional features are heavily supported. RNA editing and/or post-translational changes, which were found in the silkworm moth B. mori are characteristics of CSPs (Xuan et al, 2014(Xuan et al, , 2015(Xuan et al, , 2016(Xuan et al, , 2019Picimbon, 2017Picimbon, , 2019Picimbon, , 2023. The presence of recoding at the level of protein synthesis in the CSP family is clearly supported by the inclusion of a Glycine residue next to a Cysteine residue at certain positions, amino acid inversion, and motif insertion in protein sequence (Xuan et al, 2014(Xuan et al, , 2015(Xuan et al, , 2016(Xuan et al, , 2019Picimbon, 2017Picimbon, , 2019Picimbon, , 2023.…”

“…RNA editing and/or post-translational changes, which were found in the silkworm moth B. mori are characteristics of CSPs (Xuan et al, 2014(Xuan et al, , 2015(Xuan et al, , 2016(Xuan et al, , 2019Picimbon, 2017Picimbon, , 2019Picimbon, , 2023. The presence of recoding at the level of protein synthesis in the CSP family is clearly supported by the inclusion of a Glycine residue next to a Cysteine residue at certain positions, amino acid inversion, and motif insertion in protein sequence (Xuan et al, 2014(Xuan et al, , 2015(Xuan et al, , 2016(Xuan et al, , 2019Picimbon, 2017Picimbon, , 2019Picimbon, , 2023. They can also 'breathe' or modify their conformation in certain ways in response to ligand binding, which may be another important characteristic of the ancestor multifunctional soluble binding protein (Campanacci et al, 2003;Mosbah et al, 2003).…”

“…CSP molecules are not an insect's apnage. They are also expressed in a wide range of organisms, including many species of arthropods, crustaceans, shrimp, crab, lobster, and copepods (Zhu et al, 2019;Picimbon, 2023). They don't, however, only exist in arthropod species.…”

“…Nasonia in particular exhibits amino acid insertion (or deletion) in many various regions of the CSP protein (Figure 1). As with B. mori ribosome peptide changes, these motif insertion mutations in jewel wasp and Culex primarily affect the N-terminal region and the loop between α2 and α3 (Figure 1; Xuan et al, 2014Xuan et al, , 2016Picimbon, 2019;Yue et al, 2023). All CSPs have two disulfide bridges and four cysteines, which keep the molecule stable (Figure 1).…”