Lactobacillus fermentum HNU312 alleviated oxidative damage and behavioural abnormalities during brain development in early life induced by chronic lead exposure

Zeng, Zhen; Li, Jiahe; Jiang, Shuaiming; Xu, Meng; Ma, Teng; Sun, Zhihong; Zhang, Jiachao

doi:10.1016/j.ecoenv.2023.114543

Cited by 19 publications

(9 citation statements)

References 85 publications

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“…Sodium acetate has also been found to alleviate impaired glucose tolerance 45 . Curiously, Pb exposure significantly increased SCFA levels in the feces of ND mice, which is different from most of the literature 46,47 . We speculate that healthy mice increase SCFAs to maintain the organism in a healthy state.…”

Section: Discussionmentioning

confidence: 71%

“…45 Curiously, Pb exposure significantly increased SCFA levels in the feces of ND mice, which is different from most of the literature. 46,47 We speculate that healthy mice increase SCFAs to maintain the organism in a healthy state. However, Pb reduces the levels of SCFAs, exacerbates intestinal barrier damage, and thus worsens elevated blood glucose and IR in HFD mice.…”

Section: Discussionmentioning

confidence: 96%

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Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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BACKGROUNDLead (Pb) is an ancient toxic metal and is still a major public health issue. Our previous study found that Pb exposure promotes metabolic disorders in obese mice, but the molecular mechanisms remain unclear. The present study explored the effects of Pb exposure on glucose homeostasis in mice fed a normal diet (ND) and high‐fat diet (HFD) from the perspective of gut microbiota.RESULTSPb exposure had little effect on glucose metabolism in ND mice, but exacerbated hyperglycemia and insulin resistance, and impaired glucose tolerance in HFD mice. Pb exposure impaired intestinal tight junctions and mucin expression in HFD mice, increasing intestinal permeability and inflammation. Moreover, Pb exposure altered the composition and structure of the gut microbiota and decreased short‐chain fatty acids (SCFAs) levels in HFD mice. Correlation analysis revealed that the gut microbiota and SCFAs were significantly correlated with the gut barrier and glucose homeostasis. Furthermore, the fecal microbiota transplantation from Pb‐exposed HFD mice resulted in glucose homeostasis imbalance, intestinal mucosal structural damage and inflammation in recipient mice. However, Pb did not exacerbate the metabolic toxicity in HFD mice under depleted gut microbiota.CONCLUSIONThe findings of the present study suggest that Pb induces impairment of glucose metabolism in HFD mice by perturbing the gut microbiota. Our study offers new perspectives on the mechanisms of metabolic toxicity of heavy metals and demonstrates that the gut microbiota may be a target of action for heavy metal exposure. © 2023 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 96%

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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“…Nevertheless, certain probiotics can potentially exert a beneficial effect on the toxicity of specific substances. In this respect, the efficacy of Lactobacillus fermentum HNU312 has been demonstrated in mitigating oxidative damage and behavioral abnormalities induced by chronic lead exposure during early brain development ( Zhang Z. et al, 2023 ). The gastrointestinal microbiome can influence the metabolism of drugs and environmental pollutants in various ways, thereby altering their toxicity ( Li et al, 2008 ; Inamura, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics

Duan,

Liu,

Bai

et al. 2023

Front. Microbiol.

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BackgroundToxicity concerns persist in the fields of public health, environmental science, and pharmacology. The intricate and vital role of the gastrointestinal microbiome in influencing toxicity and overall human health has gained increasing recognition in recent years. This study presents a comprehensive bibliometric analysis to evaluate the global scientific output, emerging trends, and research focal points in the area of gastrointestinal microbiome and toxicity.MethodsThe Web of Science Core Collection database was retrieved for publications on the gastrointestinal microbiome and toxicity from 1980 to 2022. Our analysis included scholarly research papers written in English and excluded duplicate publications. We used Biblioshiny and R to summarize the count and citation metrics of included articles, and visualized research trends and keywords. CiteSpace was used to identify reference literature, keywords, and citation bursts. VOSviewer was used to visualize the network of related countries, institutions, authors, co-cited authors, and keywords.ResultsA total of 2,140 articles were included, allowing us to identify significant countries, institutions, authors, and research focal points. Our results indicate a growing trend in the field, with China and the United States leading the research. The most productive journal in this area is Science of the Total Environment. Key findings revealed that research hotspots have shifted from drugs to environmental pollutants, emphasizing microplastics. Important mechanisms studied include oxidative stress, metabolism, inflammation, and apoptosis, with target organs being the gastrointestinal tract, liver, and brain. Furthermore, we highlight the rising significance of the gut-brain axis and the usage of zebrafish as a model organism.ConclusionDespite certain limitations, such as focusing solely on English-language publications and excluding unpublished literature, our findings provide valuable insights into the current state of research on toxicity and the gastrointestinal microbiome. In the future, modifications to the gastrointestinal microbiome could offer new directions for treating and mitigating toxicity. These discoveries provide a comprehensive perspective on the broader scope of this research field.

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“…Genome sequences have been deposited in PRJEB60398 (see “Data availability”). Lactobacillus plantarum HNU082 92 , Lactobacillus paracasei HNU312 93 was provided by Prof. Jiachao Zhang from Hainan University. Akkermansia muciniphila (ATCC BAA-835) and Fusobacterium nucleatum (ATCC 25586) were purchased from ATCC.…”

Section: Methodsmentioning

confidence: 99%

Data-driven prediction of colonization outcomes for complex microbial communities

Wu,

Wang,

Tao

et al. 2024

Nat Commun

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Microbial interactions can lead to different colonization outcomes of exogenous species, be they pathogenic or beneficial in nature. Predicting the colonization of exogenous species in complex communities remains a fundamental challenge in microbial ecology, mainly due to our limited knowledge of the diverse mechanisms governing microbial dynamics. Here, we propose a data-driven approach independent of any dynamics model to predict colonization outcomes of exogenous species from the baseline compositions of microbial communities. We systematically validate this approach using synthetic data, finding that machine learning models can predict not only the binary colonization outcome but also the post-invasion steady-state abundance of the invading species. Then we conduct colonization experiments for commensal gut bacteria species Enterococcus faecium and Akkermansia muciniphila in hundreds of human stool-derived in vitro microbial communities, confirming that the data-driven approaches can predict the colonization outcomes in experiments. Furthermore, we find that while most resident species are predicted to have a weak negative impact on the colonization of exogenous species, strongly interacting species could significantly alter the colonization outcomes, e.g., Enterococcus faecalis inhibits the invasion of E. faecium invasion. The presented results suggest that the data-driven approaches are powerful tools to inform the ecology and management of microbial communities.

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Lactobacillus fermentum HNU312 alleviated oxidative damage and behavioural abnormalities during brain development in early life induced by chronic lead exposure

Cited by 19 publications

References 85 publications

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics

Data-driven prediction of colonization outcomes for complex microbial communities

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