Lactobacillus fermentum CQPC08 Attenuates Exercise-Induced Fatigue in Mice Through Its Antioxidant Effects and Effective Intervention of Galactooligosaccharide

Liu, Dong; Liu, Da Chuan; Fan, Hao; Wang, Yu

doi:10.2147/dddt.s317456

Cited by 9 publications

(5 citation statements)

References 57 publications

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“…Additionally, oxidative stress may trigger inflammatory reactions in the muscle, exacerbating muscle damage and repair processes ( Kozakowska et al, 2015 ). In an exercise-induced fatigue model, mouse livers suffered oxidative damage, whereas probiotics alleviated this phenomenon ( Liu et al, 2021 ). This study also yielded similar results, the liver and muscle tissues of mice suffered inflammatory damage after exercise, and YF01 effectively alleviated these phenomena, which indicated that YF01 suppressed the liver and muscle damage caused by exercise-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Impact of Pediococcus pentosaceus YF01 on the exercise capacity of mice through the regulation of oxidative stress and alteration of gut microbiota

Yang,

Wang,

Yang

2024

Front. Microbiol.

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Using treadmill training, this study replicated human exercise conditions and triggered exercise-induced fatigue in mice to examine the potential of Pediococcus pentosaceus YF01 in delaying this fatigue by regulating oxidative stress and its impact on the exercise capacity and gut microbiota of mice. The exercise capacity of mice was tested by conducting exhaustion tests, determining histopathological changes in mouse tissues, detecting the levels of serum biochemical markers, and evaluating the mRNA expression levels of relevant genes. YF01 prolonged the exhaustion time of mice, increased the serum levels of oxidative stress-related markers T-AOC, CAT, and GSH, as well as GLU and LA levels in the mice. YF01 decreased the levels of hepatic-related markers AST and ALT, as well as exercise-related markers LDH, BUN, UA, and CRE in the mice. YF01 upregulated the mRNA expression of MyHc I, SIRT1, and PGC in muscle tissues, as well as SOD1, SOD2, and CAT in both liver and muscle tissues. YF01 also downregulated the mRNA expression of MyHc IIa, MyHc IIb, and MyHc IIx in muscle tissues. Furthermore, YF01 increased the abundance of beneficial bacteria such as Lactobacillus and Lachnospiraceae in the gut microbiota of mice. In conclusion, P. pentosaceus YF01 may affect the exercise capacity of mice by modulating oxidative stress levels, thereby offering novel ideas for developing of sports science and human health.

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Section: Discussionmentioning

confidence: 99%

Impact of Pediococcus pentosaceus YF01 on the exercise capacity of mice through the regulation of oxidative stress and alteration of gut microbiota

Yang,

Wang,

Yang

2024

Front. Microbiol.

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“…Interestingly, at the genus level, SA‐treated mice showed a significant increase in the relative abundance of beneficial microbes: Alistipes , Rikenellaceae , Parabacteroides , and Lactobacillus . Recent studies have reported that Lactobacillus positively regulates Ex‐induced fatigue [ 50 ] and mental exhaustion. [ 51 ] Alistipes are strongly associated with chronic stresses and human health, which could be beneficial in alleviating memory impairments in dysbiosis and disease.…”

Section: Discussionmentioning

confidence: 99%

Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice

Zhu

Shen²,

Wang

et al. 2023

Molecular Nutrition Food Res

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Scope Salidroside (SA) is an active compound derived from Rhodiola rosea and is widely used in healthcare foods. However, the underlying mechanism and its specific role in regulating the gut microbial community during exercise (Ex) remains unknown. Methods and results Mice are subjected to a weight‐loaded swimming test (WST) Ex to determine how gut microbiota affects the antifatigue activity of SA. The SA‐treated group mice (100 mg kg−1.bw.) display a significant increase in swimming time compared to the control group (26.2 versus 10.5 min, p < 0.01), as well as an increase in respiratory enzymatic activities after swimming. The respiratory enzymatic activities are significantly higher in the SA‐treated group than in the RS (regular rest) group after swimming. The bacteria profiles in the Ex + SA group change significantly with higher species diversity and abundance. Receiver operating characteristic (ROC) curves of Alistipes, Rikenellaceae, Parabacteroides, Candidatus Arthromitus, and Lactobacillus indicate a high diagnostic utility to distinguish SA treatment. Microbial function analysis shows that SA may improve Ex‐induced fatigue by modulating energy metabolism‐related processes. Conclusions SA demonstrates antifatigue effects on various levels of regulating energy metabolism and microbial composition, providing insights into the underlying mechanisms of SA as a natural prebiotic.

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“…SOD protects cells from damage by removing superoxide anions in the microenvironment (32). GSH-Px specifically catalyzes the reduction of hydrogen peroxide and protects the cell membrane (33). According to the serological indexes, the waterfall forest environment notably improved the levels of endogenous GSH-Px and SOD in participants but reduced the level of MDA.…”

Section: B Cmentioning

confidence: 99%

Mechanism of the Huangguoshu waterfall forest environment’s promotive effect on human health in Guizhou, China

Zhu¹,

Zhao²,

Ouyang³

et al. 2022

Ann Transl Med

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Background: The aim of this study was to investigate the specific mechanisms underlying the human health-promoting effects of the forest environment at Huangguoshu Falls, Guizhou, China.Methods: Ninety-five participants were recruited and an eye tracker was used to record fixation and sweep indices. A questionnaire was also used to evaluate the effects of different subject environments on human emotions, perceived recovery and preferences. Thereafter, 24 participants with chronic fatigue syndrome (CFS) were recruited and the participants' fatigue and stress-related scale indices and inflammatory factor levels were examined. Serum metabolites of the participants under different time waterfall forest interventions were detected by ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q/TOF-MS).Results: Eye tracking paradigm analysis showed that the "waterfall" element was the most interesting element for participants and that the "charm" of the waterfall forest environment could be well perceived by participants. Scores on the Fatigue Scale, Anxiety Scale and Depression Scale decreased as the duration of treatment in the waterfall forest environment increased. Levels of inflammatory factors decreased after treatment in the waterfall forest environment. At the same time the level of antioxidants, represented by L-ascorbic acid, increased significantly. Conclusions:The charm of the Huangguoshu waterfall scenery could be perceived by the participants and have a positive modulating effect on mood and cognitive function. In addition, the unique mixture of negative oxygen ions in this environment can increase the content of endogenous antioxidants and balance the metabolism of choline and amino acids.

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Lactobacillus fermentum CQPC08 Attenuates Exercise-Induced Fatigue in Mice Through Its Antioxidant Effects and Effective Intervention of Galactooligosaccharide

Cited by 9 publications

References 57 publications

Impact of Pediococcus pentosaceus YF01 on the exercise capacity of mice through the regulation of oxidative stress and alteration of gut microbiota

Impact of Pediococcus pentosaceus YF01 on the exercise capacity of mice through the regulation of oxidative stress and alteration of gut microbiota

Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice

Mechanism of the Huangguoshu waterfall forest environment’s promotive effect on human health in Guizhou, China

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