Lactobacillus Bacteria in Breast Milk

Łubiech, Katarzyna; Twarużek, Magdalena

doi:10.3390/nu12123783

Cited by 52 publications

(55 citation statements)

References 88 publications

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“…While the infant gut microbiome evolves continuously compared to the adult gut microbiome, infant probiotic supplementation may not have a long-term effect on colonization and health outcomes [ 21 ]. Lactobacillus present in breast milk also serves as a probiotic for the developing infant [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Lactobacillus Strains Capable of Fermenting Fructo-Oligosaccharides and Inulin

2021

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Novel probiotic strains that can ferment prebiotics are important for functional foods. The utilization of prebiotics is strain specific, so we screened 86 Lactobacillus strains and compared them to Bifidobacterium breve 2141 for the ability to grow and produce SCFA when 1% inulin or fructo-oligosaccharides (FOS) were provided as the carbon source in batch fermentations. When grown anaerobically at 32 °C, ten Lactobacillus strains grew on both prebiotic substrates (OD600 ≥ 1.2); while Lactobacillus coryniformis subsp. torquens B4390 grew only in the presence of inulin. When the growth temperature was increased to 37 °C to simulate the human body temperature, four of these strains were no longer able to grow on either prebiotic. Additionally, L. casei strains 4646 and B441, and L. helveticus strains B1842 and B1929 did not require anaerobic conditions for growth on both prebiotics. Short-chain fatty acid analysis was performed on cell-free supernatants. The concentration of lactic acid produced by the ten Lactobacillus strains in the presence of prebiotics ranged from 73–205 mM. L. helveticus B1929 produced the highest concentration of acetic acid ~19 mM, while L. paraplantarum B23115 and L. paracasei ssp. paracasei B4564 produced the highest concentrations of propionic (1.8–4.0 mM) and butyric (0.9 and 1.1 mM) acids from prebiotic fermentation. L. mali B4563, L. paraplantarum B23115 and L. paracasei ssp. paracasei B4564 were identified as butyrate producers for the first time. These strains hold potential as synbiotics with FOS or inulin in the development of functional foods, including infant formula.

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Section: Introductionmentioning

confidence: 99%

Identification of Lactobacillus Strains Capable of Fermenting Fructo-Oligosaccharides and Inulin

2021

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“…Both Bifidobacterium and Lactobacillus spp. are present in human milk and S. epidermidis colonize maternal skin; and their metabolic functions in falta una palabra aqui are related to breastfeeding, as Bifidobacterium species metabolize human milk oligosaccharides (HMOs) ( James et al, 2019 ) and Lactobacillus species including L. rhamnosus can metabolize lactose ( Lubiech and Twaruzek, 2020 ). Cessation of breastfeeding seems to be the major determinant in the “maturation” of the gut microbiota, characterized by an increase in Firmicutes ( Stewart et al, 2018 ), concordant with other studies showing an increase specifically in the Lachnospiraceae and Ruminococcaceae families ( Laursen et al, 2016 ), which can metabolize plant-derived complex carbohydrates introduced with solid foods ( Flint et al, 2012 ).…”

Section: Bacterial Gut Microbiota Dynamics and Modulation During The First 5 Years Of Lifementioning

confidence: 99%

Bacterial Gut Microbiota and Infections During Early Childhood

et al. 2022

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Gut microbiota composition during the first years of life is variable, dynamic and influenced by both prenatal and postnatal factors, such as maternal antibiotics administered during labor, delivery mode, maternal diet, breastfeeding, and/or antibiotic consumption during infancy. Furthermore, the microbiota displays bidirectional interactions with infectious agents, either through direct microbiota-microorganism interactions or indirectly through various stimuli of the host immune system. Here we review these interactions during childhood until 5 years of life, focusing on bacterial microbiota, the most common gastrointestinal and respiratory infections and two well characterized gastrointestinal diseases related to dysbiosis (necrotizing enterocolitis and Clostridioides difficile infection). To date, most peer-reviewed studies on the bacterial microbiota in childhood have been cross-sectional and have reported patterns of gut dysbiosis during infections as compared to healthy controls; prospective studies suggest that most children progressively return to a “healthy microbiota status” following infection. Animal models and/or studies focusing on specific preventive and therapeutic interventions, such as probiotic administration and fecal transplantation, support the role of the bacterial gut microbiota in modulating both enteric and respiratory infections. A more in depth understanding of the mechanisms involved in the establishment and maintenance of the early bacterial microbiota, focusing on specific components of the microbiota-immunity-infectious agent axis is necessary in order to better define potential preventive or therapeutic tools against significant infections in children.

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“…In support of this hypothesis, both HM and breastfed infants’ stool samples seem to share specific bacteria patterns (mainly Lactobacillus spp., Lactobacillus plantarum , Bifidobacterium breve and Bifidobacterium longum subsp. longum ), with significant differences also seen compared to strains obtained in faeces from formula-fed infants [ 34 , 69 , 70 , 71 , 72 ]. Interestingly, this similarity in microbial composition remains throughout the first year of life [ 73 ].…”

Section: Human Milk Microbioma Functions and Activitymentioning

confidence: 99%

Short- and Long-Term Implications of Human Milk Microbiota on Maternal and Child Health

García-Ricobaraza

García-Santos

Escudero-Marín

et al. 2021

IJMS

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Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, gangliosides or polyamines, among others; in addition, HM has a “bifidogenic effect”, a prebiotic effect, as a result of the low concentration of proteins and phosphates, as well as the presence of lactoferrin, lactose, nucleotides and oligosaccharides. Recently, has been a growing interest in HM as a potential source of probiotics and commensal bacteria to the infant gut, which might, in turn, influence both the gut colonization and maturation of infant immune system. Our review aims to address practical approaches to the detection of microbial communities in human breast milk samples, delving into their origin, composition and functions. Furthermore, we will summarize the current knowledge of how HM microbiota dysbiosis acts as a short- and long-term predictor of maternal and infant health. Finally, we also provide a critical view of the role of breast milk-related bacteria as a novel probiotic strategy in the prevention and treatment of maternal and offspring diseases.

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Lactobacillus Bacteria in Breast Milk

Cited by 52 publications

References 88 publications

Identification of Lactobacillus Strains Capable of Fermenting Fructo-Oligosaccharides and Inulin

Identification of Lactobacillus Strains Capable of Fermenting Fructo-Oligosaccharides and Inulin

Bacterial Gut Microbiota and Infections During Early Childhood

Short- and Long-Term Implications of Human Milk Microbiota on Maternal and Child Health

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