Lactobacillus and health

Lee, Wen-Ling; Tsui, Kuan‐Hao; Wang, Peng-Hui

doi:10.1016/j.jcma.2016.05.002

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…have been implicated in the variations in the composition of the “normal” vaginal microbiota. Risk of infection and PTB is modified by variations in maternal/fetal genetic composition and epigenetics, which ultimately determines the intensity of immune response to altered vaginal microbiota during gestation ( 119 – 125 ). These discrepancies have created a huge burden on the development of effective preventive and therapeutic strategies to improved women's health.…”

Section: Discussionmentioning

confidence: 99%

The Vaginal Microenvironment: The Physiologic Role of Lactobacilli

2018

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In addition to being a passage for sperm, menstruum, and the baby, the human vagina and its microbiota can influence conception, pregnancy, the mode and timing of delivery, and the risk of acquiring sexually transmitted infections. The physiological status of the vaginal milieu is important for the wellbeing of the host as well as for successful reproduction. High estrogen states, as seen during puberty and pregnancy, promote the preservation of a homeostatic (eubiotic) vaginal microenvironment by stimulating the maturation and proliferation of vaginal epithelial cells and the accumulation of glycogen. A glycogen-rich vaginal milieu is a haven for the proliferation of Lactobacilli facilitated by the production of lactic acid and decreased pH. Lactobacilli and their antimicrobial and anti-inflammatory products along with components of the epithelial mucosal barrier provide an effective first line defense against invading pathogens including bacterial vaginosis, aerobic vaginitis-associated bacteria, viruses, fungi and protozoa. An optimal host-microbial interaction is required for the maintenance of eubiosis and vaginal health. This review explores the composition, function and adaptive mechanisms of the vaginal microbiome in health and those disease states in which there is a breach in the host-microbial relationship. The potential impact of vaginal dysbiosis on reproduction is also outlined.

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Section: Discussionmentioning

confidence: 99%

The Vaginal Microenvironment: The Physiologic Role of Lactobacilli

2018

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“…Lactobacillus conduces to hydrogen peroxide production, which curbs the excessive growth of various other pathogens (e.g., group B Streptococci, Escherichia coli , and S aureus ). [34] Bifidobacterium can promote the growth of other healthy bacteria by acidifying the intestinal microenvironment and improving intestinal metabolism by accelerating lipid metabolism to treat high-fat diet-triggered obesity. [35] Akkermansia contributes to the decrease of fat accumulation by lowering both liver and serum cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial

Tian,

Wu,

Zhao

et al. 2024

Medicine

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Background: Hyperlipidemia is a common feature of chronic diseases. The aim of this work was designed to assess the role of probiotics (Lactobacillus casei Zhang, Bifidobactetium animalis subsp. lactis V9, and Lactobacillus plantarum P-8) in the treatment of hyperlipidemia. Methods: Thirty three patients with hyperlipidemia were randomly divided into a probiotic group (n = 18) and a control group (n = 15). The probiotic group was administered probiotics (2 g once daily) and atorvastatin 20 mg (once daily), and the control group was administered a placebo (2 g once daily) and atorvastatin 20 mg (once daily). Serum and fecal samples were gathered for subsequent analyses. Results: Time had a significant effect on the total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) levels in the probiotic and control groups (P < .05). The gut microbial abundance in the probiotic group was markedly higher than that in the control group following 3-month probiotic treatment (P < .05). At the phylum level, probiotics exerted no notable effects on the relative abundance of Firmicutes, Bacteroidetes, and Actinobacteria but elevated that of Tenericutes and reduced Proteobacteria. At the genus level, probiotics increased the relative abundance of Bifidobacterium, Lactobacillus, and Akkermansia, and decreased that of Escherichia, Eggerthella, and Sutterella relative to the control group in months 1, 2, and 3 (P < .05). Conclusions: Probiotics optimize the gut microbiota structure and decrease the amount of harmful bacteria in patients with hyperlipidemia. Probiotics can influence the composition of gut microorganisms and increase their diversity and abundance in vivo. It is recommended to use probiotics combined with atorvastatin to treat patients with hyperlipidemia.

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Lactobacillus and lower genital tract infection

Lee

Wang

2017

Journal of the Chinese Medical Association

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Lactobacillus and health

Cited by 10 publications

References 13 publications

The Vaginal Microenvironment: The Physiologic Role of Lactobacilli

The Vaginal Microenvironment: The Physiologic Role of Lactobacilli

Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial

Lactobacillus and lower genital tract infection

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