Lactic Dehydrogenase Virus

Rowson, K. E. K.; Mahy, Brian W. J.

doi:10.1007/978-3-7091-8378-6_1

Cited by 40 publications

(40 citation statements)

References 217 publications

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“…Lactate dehydrogenase-elevating virus (LDV) induces life-long persistent viraemia in ordinary mice; however, no significant symptoms have been reported except for an elevation of certain plasma enzymes and deposition of immune complexes in the kidneys (Riley et al, 1960;Oldstone & Dixon, 1971;Rowson & Mahy, 1975). Murphy et al (1970) described a polioencephalomyelitis in C58 mice receiving transplanted syngeneic tumour cells.…”

Section: Introductionmentioning

confidence: 99%

Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro

Inada

Yamazaki

1991

Journal of General Virology

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Section: Introductionmentioning

confidence: 99%

Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro

Inada

Yamazaki

1991

Journal of General Virology

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“…OuI control value of <500 mU/ml demonstrated the absence of LDV infection in the untreated mice (Rowson & Mahy, 1975). The higher values found within the LAC-bearing mice were not comparable to those reported from LDV-infected tumour-bearing animals in which, due to synergism between the virus and tumour, 50-fold (Riley & lro6blewski, 1960) or even 100-fold (Notkins, 1971) (Notkins, 1965).…”

Section: Methodsmentioning

confidence: 79%

“…Firstly, the virus-like particles observed within the LAC cells were confined to these tumour cells and, uinlike LDV, which rapidly infects and replicates inside macrophages (Rowson & Mahy, 1975), they were not seen in macrophages either in the peritoneal cavity itself or in the liver or in any of the lymphoretictular organs examined (spleen, thymus and lymph nodes) in both the normal and LAC-bearing mice used in this study. The particles seen within the LAC cells closely-resembled typical C-type virus particles.…”

Section: Methodsmentioning

confidence: 82%

“…Thirdly, unlike LDV, which does not persist within cells maintained in culture (Rowson & Mahy, 1975), the virus-like particles seen withini the LAC cells were retained even after prolonged subculturing.…”

Section: Methodsmentioning

confidence: 96%

“…The pyruvate-dependent oxidation of reduced nicotinamide-adenine dinucleotide was measured at 27°C at 340 nm on a recording UV spectrophotometer, essentially by the method of Rowson & Mahy (1975 the marked hepatosplenomegaly evident 8 days after i.p. administration of the microorganism (Fig.…”

Section: Methodsmentioning

confidence: 99%

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Inhibition by the Landschütz ascites carcinoma of the granulomatous inflammatory response to C. parvum

McIntosh¹,

Pugh-Humphreys²,

Fraser³

et al. 1982

Br J Cancer

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Summary.-I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschutz ascites carcinoma (LAC) 24 h after CP substantially reduced the intensity of the inflammatory response, and decreased both the frequency and size of the hepatic granulomas, as revealed by morphometric analysis of histological sections.The difference in cellular composition of the granulomas between the experimental groups, as revealed by light microscopy, was further emphasized and characterized by ultrastructural studies. These revealed the predominance of macrophages within the granulomas in tumour-bearing mice, in contrast to the predominance of epithelioid cells in the lesions which developed in mice given CP alone.Our experimental findings show that the inhibitory effect of the growing LAC on granuloma formation in response to CP cannot be ascribed to (a) sequestration of the microorganism within the growing tumour, (b) a nonspecific inflammatory stimulus, (c) diversion and seqestration of mononuclear phagocytes in the growing tumour or (d) the presence of lactate dehydrogenase-elevating virus in either the host or tumour cells. The inhibition of liver granuloma formation is consistent with an effect mediated by soluble, heat-stable tumour-associated factor(s).

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Modulation of natural killer (NK) cell activity during FLV‐P virus infection of mice

Migliorati

Jezzi²,

Frati

et al. 1983

Intl Journal of Cancer

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We analyzed the effects of a polycythemic substrain of Friend leukemia virus, i.e. the FLV-P virus, on splenic NK activity of DBA/2 susceptible mice. One day after virus injection a significant increase of NK activity was found, which persisted until day 10. On the other hand, 14-21 days after virus injection a marked and significant depression of activity was measured. This depression was associated with the appearance of suppressor cells able to inhibit the lytic activity of untreated splenocytes when mixed in vitro in the 4 h 51Cr-release assay. The suppressor cell population was insensitive to treatment with anti-Thy 1.2 plus complement, was adherent to Sephadex G-10 and nylon, but did not adhere to plastic, suggesting it is neither a T-cell nor a typical macrophage. The possible relevance of NK activity modulation in relation to the induction of leukemia is discussed.

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Lactic Dehydrogenase Virus

Cited by 40 publications

References 217 publications

Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro

Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro

Inhibition by the Landschütz ascites carcinoma of the granulomatous inflammatory response to C. parvum

Modulation of natural killer (NK) cell activity during FLV‐P virus infection of mice

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