Lactic Dehydrogenase: A Biochemical Marker for Preeclampsia–Eclampsia

Gupta, Amrit; Sachan, Rekha; Natu, SM; Shaili, Mohan

doi:10.1007/s13224-011-0093-9

Cited by 66 publications

(104 citation statements)

References 4 publications

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“…Evaluation of LDH level during preclampsia can be useful in making decision, regarding the management strategies to improve the maternal and fetal outcome. 30 Similar type of finding was obtained by Jaiswar S P et al…”

Section: Discussionsupporting

confidence: 81%

A comparative study of serum uric acid, glucose, calcium and magnesium in pre-eclampsia and normal pregnancy

et al. 2017

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A comparative study of serum uric acid, glucose, calcium and magnesium in eclampsia and normal pregnancy Background: Preclampsia is associated with liver function abnormalities and renal function impairment.The objective of this study is to compare serum uric acid, glucose, calcium and magnesium in preclampsia with normal pregnancy. Materials and methods: Normal pregnant women and pre eclamptic women of age group 20-40 years were included. Serum magnesium, calcium, glucose, uric acid were analyzed. Results: Mean serum magnesium level in preclampsia (1.83 ± 0.21mg/dl) was lesser in comparison to normal pregnant women (2.03 ± 0.16 mg/dl). Serum calcium level was lower (8.10 ±0.56mg/dl) than control (9.59 ±0.62 mg/dl) with p<0.001. Uric acid, glucose and lactate dehydrogenase in preclamptic women was significantly higher than that in normal pregnant women (6.14 ± 0.85 vs.4.01 ± 0.62, p=<0.001), (94.17± 18.65 vs.86.34 ± 10.19, p=0.033) and ( 466.80 ± 97.29 vs. 194.22 ± 39.76, p=<0.001) respectively. Conclusion: There were significant changes in serum magnesium, uric acid, calcium, glucose, lactate dehydrogenase and total protein in pregnant women.

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Section: Discussionsupporting

confidence: 81%

A comparative study of serum uric acid, glucose, calcium and magnesium in pre-eclampsia and normal pregnancy

et al. 2017

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“…[7][8][9][10] In the present study the LDH levels were significantly raised with the severity of the disease (P<0.001) and this was in accordance with the study done by Jaiswar SP et al, Qublan et al and Liggy A et al 7,8,11 The mean gestational age at the time of delivery in the present study was significantly less in patients with increasing LDH levels (P<0.05). This indicates increase in preterm deliveries in patients with higher LDH levels.…”

Section: Discussionsupporting

confidence: 91%

“…This will help in making decision, about the management guidelines for better maternal and fetal outcome. 7 Objectives of present study were to compare serum LDH levels in the normal pregnant women and in women with preeclampsia and eclampsia in ante-partum period and to study the association of maternal and perinatal outcomes with serum LDH levels.…”

Section: Introductionmentioning

confidence: 99%

Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia, Gujarat

Jain¹,

Upadhyay²,

Mehta³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease in this group of women. This will help in making decision, about the management guidelines to the better the maternal and fetal outcome. Objective of present study was compare serum LDH levels in the normal pregnant women and in women with preeclampsia and eclampsia in ante-partum period and to study the association of maternal and perinatal outcomes with serum LDH levels.Methods: It is a prospective study done at Obstetrics and Gynecology department, GMERS medical college and civil hospital, Gandhinagar during August-September 2016. Participants were divided into four groups according to severity of disease and into three groups according to serum LDH level.Results: Mean level of LDH (IU/l) in Control, Mild pre-eclampsia, Severe pre-eclampsia & Eclampsia was 302.33, 398.56, 675.26 & 1589.85 respectively. Out of total 34 cases with LDH level >800 IU/L, 47.1% cases had ≥160 mm hg SBP & 52.9% had ≥110 mm hg DBP, mean gestational age and mean baby weight was 36.88 week and 1950 gm, mean apgar score at 10 min was 6.96, 47.1% had uneventful outcome, whereas 58.8% had neonatal complications and 5.9% had neonatal death. Almost 26.5% still births, 47.1% perinatal deaths.Conclusions: Higher serum LDH levels during pregnancy have significant association with severity of disease and maternal and fetal outcomes in patients of preeclampsia and eclampsia and can be considered as a supportive prognostic tool from early third trimester.

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“…The median LDH value was high in group1. 8 This is similar to the results obtained by S P Jaiswar et al, which showed 69.4% of patients with eclampsia had LDH >800 IU/L while only 19.4% had levels between 600 and 800 IU/L. They also observed that there is a significant rise in LDH levels with increasing severity of the disease.…”

Section: 3supporting

confidence: 90%