Lactic acidosis is associated with multiple organ failure and need for ventilator support in patients with severe hemorrhage from trauma

Lefering, Rolf; Zielske, D.; Bouillon, Bertil; Hauser, Carl J.; Levy, Howard

doi:10.1007/s00068-013-0285-3

Cited by 13 publications

(11 citation statements)

References 16 publications

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“…Lefering ET cols 6 demonstrated correlation of serum lactate levels with mortality, with the highest levels present in patients with late mortality, after 48 h of admission. In this study, no correlation was found between lactate and death, either early or late.…”

Section: Discussionmentioning

confidence: 95%

“…Lactate is a product of anaerobic metabolism and can be used as a marker of hypoxia in different states of shock. Elevated serum levels on admission of multiple trauma patients is related to higher mortality 3 5 7 15 , higher mortality in patients affected by septic shock 6 and predict blood products need and also may aid in the early detection of severity 3 . Several researchers have established the use of lactate as a diagnostic and prognostic marker of severity and mortality 1 7 9 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Lactate clearance is reported as a predictor of mortality in patients with stable vital signs or volume loss of less quantities 5 6 12 . In this study, these variables were independent, probably due to limited sample, differing from other authors 4 5 7 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Checking it in association with blood pressure it is possible to have severe injury indicative 7 10 12 . Some studies have linked lactate >4 mmol/l as a major criterion of severity and chance of survival, rarely found in stable patients even with comorbidities 6 8 10 . Others show that patients with high blood lactate have higher risk of death compared to those with levels within the normal laboratory range 3 4 .…”

Section: Introductionmentioning

confidence: 99%

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Lactate as Predictor of Mortality in Polytrauma

Freitas

Franzon

2015

ABCD, arq. bras. cir. dig.

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Background: The lactate is a product of anaerobic metabolism; it can be used as a marker on demand and availability of oxygen. Changes in lactate levels can be effectively used as a marker in resuscitation maneuvers, even in patients with stable vital signs. Aim: To verify the lactate clearance as a predictor of mortality in trauma patients, in need of intensive care. Method: A total of 851 patients were admitted in ICU, in which 146 were victims of multiple trauma; due to the exclusion criteria, were included 117. Results: Patients were 87% male, mean age 32.4 years, motorcycle drivers, Glasgow coma scale between 3-8, affected by cranial trauma, followed by abdominal trauma. Was verified mortality up to 48 h and global mortality, that did not show statistical relationship between lactate clearance and mortality (p=0.928). Conclusion: There is no correlation between admission lactate or lactate clearance and mortality in patients treated with multiple trauma.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lactate as Predictor of Mortality in Polytrauma

Freitas

Franzon

2015

ABCD, arq. bras. cir. dig.

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“…Initial high lactate level on admission of patients with multiple traumas is correlated with higher mortality rates 18 -21 . Because of higher death rate patients affected by septic shock 22 and predicting the need for blood products, it can also help to diagnose severity early 19 . The use of lactate as an indicator of severity and mortality was established by several investigators 14, 18 -20, 22 -24 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lactate and Lactate Clearance as a Marker of Outcome in Trauma ICU

Mishra

Hakim

Mishra

et al. 2020

Asian Journal of Pharmaceutical Research and Health Care

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Hypo-perfusion is usual in patients suffering from traumatic injury that may be indicated by serum lactate elevation. This study was performed to analyze the relation of the lactate value with trauma mortality and its clearance. The research included a total of 202 trauma patients admitted into ICU. Study parameters such as patient demography, injury mechanism, Blood Pressure (BP), heart rate (HR), Glasgow Coma Scale (GCS) and level of lactate in the blood. All these parameters were documented in the first 3 hours of hospitalization, and lactate clearance was recorded between 3 and 9 hours afterwards. For the study point; death up to 7 days was considered as a direct impact of trauma and considered in study. The study was divided into two subgroups, either expired (n=79) or survivors (n=123) according to the final outcome. The mean age, mean body weight, sex ratio, HR, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in both groups were comparable. The difference in lactate at admission, lactate at 6 hours and lactate clearance in between survivors and deaths were found to be insignificant statistically. Among trauma patients there is no significant relationship between lactate admission or lactate clearance and mortality. Higher sample size may be appropriate for definitive proof to be reached.

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