Lactic Acidosis Associated With Metastatic Osteogenic Sarcoma

Ketones and lactate “fuel” tumor growth and metastasis

“…[23][24][25][26][27][28][29][30][31][32][33] In fact, lactic-acidosis (due to the over-production and/or accumulation of serum lactate) is often the cause of death in patients with metastatic breast cancer, or other types of metastatic cancer. [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] However, a causative role for L-lactate production in tumor metastatic progression has not yet been suggested or demonstrated.…”

Type B lactic acidosis and metastatic breast cancer

“…Nine of the patients had lung cancer (7 small cell), 2 had breast cancer, and 1 had colon cancer. To this list may be added 8 additional cases for a total of 20; 1 osteogenic sarcoma [6], 3 lung cancer [7,8], and 4 breast cancer cases [1, 9, 10, text] which are summarized in Table 1. Although a seventh breast cancer case was reported by McConnell etat.…”

“…1. In some of the reported cases liver involvement was minimal [91 or absent [6,7,15 namics, and in some patients had the deleterious effects of reducing ionized calcium and increasing pCO2 [27]. Thus the routine use of bicarbonate in lactic acidosis of any etiology should probably be discouraged.…”