Lactic Acid Production by Oral <i>Streptococcus mitis</i> Inhibits the Growth of Oral <i>Capnocytophaga</i>

Mashimo, Paul A.; Yamamoto, Yotaro; Nakamura, Masakazu; Reynolds, Homer S.; Genco, R. J.

doi:10.1902/jop.1985.56.9.548

Cited by 24 publications

(12 citation statements)

References 24 publications

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“…Various in vitro and in vivo studies have shown that production of hydrogen peroxide by probiotic bacterial strains can inhibit the growth of pathogenic bacterial species (Mashimo et al 1985, Tompkins & Tagg 1986, Makras & De Vuyst 2006, Falagas et al 2007. In this aspect, Hillman & Shivers (1988) showed in a gnotobiotic rat model that the level of A. actinomycetemcomitans colonization in these rats was 45-fold lower in animals infected with a hydrogen peroxide-producing S. sanguinis strain when compared with rats infected with a hydrogen peroxide-deficient mutant of this S. sanguinis strain.…”

Section: Antimicrobial Substances Produced By Probioticsmentioning

confidence: 99%

Do probiotics offer opportunities to manipulate the periodontal oral microbiota?

Teughels

Loozen

Quirynen

2011

J Clinic Periodontology

161

138

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Background: As in other fields of healthcare, probiotics have been introduced for prevention and treatment of periodontal diseases. Objective: This review was initiated to explore whether the use of probiotics can influence the periodontal microbiota and periodontal health. Materials and Methods: Literature on the mode of action of oral probiotics was reviewed and a systematic review was performed on the microbiological and clinical effects of oral probiotics on periodontal health. Results: Three animal and 11 in vivo human studies were retrieved. Six studies reported on microbiological effects whereas eight studies report on clinical effects. Seven studies were performed on healthy or gingivitis patients and four studies on periodontitis patients. Many of the retrieved studies are pilot in nature and with low quality. The high degree of heterogeneity between studies hampered analysis. Conclusion: Taking into consideration all limitations, the currently available data indicate an effect of probiotics on the oral microbiota and a more limited effect on clinical periodontal outcome measures. However, there is an urgent need for properly conducted clinical trials where probiotics are used as adjuncts to standard periodontal care, similar to antibiotics, using probiotic strains with, at least at an in vitro level, proven periodontal probiotic effects.

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Section: Antimicrobial Substances Produced By Probioticsmentioning

confidence: 99%

Do probiotics offer opportunities to manipulate the periodontal oral microbiota?

Teughels

Loozen

Quirynen

2011

J Clinic Periodontology

161

138

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“…Interactions between mierobial species have been shown to play a significant role for the growth of microorganisms in in vitro studies (5,6,8,14,23,26) and in experitnental infections in laboratory animals (1,4,13,15,19,28,30). In more complex iti vivo systems, such as subgingival plaque, mierobial interactions have beet-i less well studied.…”

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confidence: 99%

Microbial associations in periodontitis sites before and after treatment

Wikström¹,

Renvert²,

Johnsson³

et al. 1993

Oral Microbiology and Immunology

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Duplicate samples from 110 periodontal sites of 6 mm or more pocket depth in 16 patients were analyzed for the presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Capnocytophaga spp., Campylobacter rectus, Eikenella corrodens and Fusobacterium nucleatum. The sites were sampled before and after nonsurgical periodontal treatment. No statistically significant associations were found before treatment between any of the analyzed species. After treatment, statistically significant associations were found between E. corrodens and all the other species, F. nucleatum and P. intermedia; Capnocytophaga spp. and C. rectus; P. intermedia vs Capnocytophaga spp. and P. gingivalis; and C. rectus vs Capnocytophaga spp. and A. actinomycetemcomitans. Some of these associations could be explained either by patient-related factors or site-related characteristics such as the pocket depth. The proportion of P. gingivalis seemed to be unrelated to the proportion of P. intermedia in the samples. If one of the analyzed microbes was found in one of the sampled pockets in a patient, the probability of finding that microbe in all the sampled sites in the same patient before treatment was more than 50%. This probability was reduced after treatment for many species, especially P. gingivalis, which showed a probability of zero. The probability of detecting a bacterial species on at least one additional site if it was present on one in the same individual was nearly 100%, both before and after treatment, for all species studied. This study has shown several potential microbial associations in the subgingival plaque flora of deep periodontal pockets.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The number of different species which reside in this area has been estimated at over 300 (28), Electron microscopy of in situ plaque sections has revealed that the organisms live in densely packed masses (19), Thus, there are continuous opportunities for interactions between species within this niche and between the microorganisms and the host. For a considerable time, investigators have examined associations between microbial species in vitro and laboratory animals, seeking cell surface interactions (18,25,36), antagonisms (1,3,16,17,22,31,41,43,44,47), synergisms or symbiosis (8,9,38,45) and associations which play a role in "mixed infections" (7, 20, 21, 23, 24, 26, 27, 30, 32-34, 37, 40, 41), There have been few studies which have examined microbial associations as they exist in human dental plaque (46,48), One widely studied interaction has been between the suspected pathogen, Actinobacittus actinomycetemcomitans and 3 possibly beneficial species. Streptococ-cus sanguis.…”

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confidence: 99%

Associations between microbial species in subgingival plaque samples

Socransky

Haffajee

Dzink

et al. 1988

Oral Microbiology and Immunology

157

115

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Samples of subgingival plaque were taken from 275 active and inactive sites in 35 subjects with destructive periodontal diseases. The predominant cultivable microbiota was determined in each of the samples by characterizing 50 randomly selected isolates recovered on anaerobically incubated Trypticase soy agar supplemented with 5% sheep blood. Microbial associations between species were determined by computing the odds ratio of a site being infected by a “target” species in the presence of an “effector” species. Data are presented for 22 numerically dominant “effector” species and 8 “target” species which consisted of suspected periodontal pathogens. These included Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Bacteroides gingivalis, Bacteroides intermedicus, Bacteroides melaninogenicus, Peptostreptococcus micros, Streptococcus intermedius and Wolinella recta. Positive associations were considered to be relationships in which the odds ratio of detecting a “target” species was >2:1 in the presence of the “effector” species, while negative associations were defined as those in which the odds ratio of detecting the “target” species was < 0.5:1 in the presence of the “effector” species. In general, species of streptococci, an unnamed Actinomyces sp. and Propionibacterium acnes showed a negative association with the 8 suspected pathogens, while many Gram‐negative species tended to show a positive association with these suspected pathogens. There appeared to be specificity in the associations observed. For example, S. intermedius was positively associated with Streptococcus mitis and Streptococcus sanguis I, but negatively associated with Bacteroides forsythus. In contrast, W. recta was negatively associated with S. mitis and Streptococcus sanguis I, but positively associated with Bacteroides forsythus. S. sanguis II, Streptococcus uberis, P. acnes, Capnocytophaga ochracea and an unnamed Actinomyces sp. showed negative associations with 4 of the suspected periodontal pathogens, while B. gingivalis, Fusobacterium nucleatum and the Eubacterium sp. showed only positive or “neutral” associations with the “target” species. Data from this and other investigations suggest that microbial associations might play an important role in controlling the composition of subgingival plaque and, thus, be a major determinant of health or destructive periodontal diseases.

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Lactic Acid Production by Oral Streptococcus mitis Inhibits the Growth of Oral Capnocytophaga

Cited by 24 publications

References 24 publications

Do probiotics offer opportunities to manipulate the periodontal oral microbiota?

Do probiotics offer opportunities to manipulate the periodontal oral microbiota?

Microbial associations in periodontitis sites before and after treatment

Associations between microbial species in subgingival plaque samples

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