Lactic acid production by electrodialysis fermentation using immobilized growing cells

Nomura, Yasuya; Iwahara, M.; Hongo, Motoyoshi

doi:10.1002/bit.260300613

Cited by 91 publications

(39 citation statements)

References 12 publications

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“…However, comparatively high amounts of solvents are needed for extraction, and toxic effects are provoked by solvents. In the electrodialysis units, cells adhered to membranes during the process, leading to decreased efficiency in the overall recovery system (Nomura et al, 1987;Davison and Scott, 1992;Zihao and Kefeng, 1995;Moldes et al, 2003). Lactic acid from fermentation broth can be recovered using anion polymeric adsorbents, which were strong, moderate, or weak basic anion exchange resins adsorbing lactic acid below and above of its pKa (Moldes et al, 2003;Kulprathipanja and Oroshar, 1991).…”

Section: Introductionmentioning

confidence: 99%

L(+)-Lactic acid recovery from cassava bagasse based fermented medium using anion exchange resins

Nampoothiri

Pandey

2008

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

L(+)-Lactic acid recovery from cassava bagasse based fermented medium using anion exchange resins

Nampoothiri

Pandey

2008

Braz. arch. biol. technol.

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“…In order to alleviate the osmotic stress inhibition in organic acid fermentations and to further increase the yield and productivity of organic acid, a lot of metabolic and process engineering techniques have been developed (Roffler, 1984). The process engineering strategies mainly involved with the in situ product removal systems, such as precipitation, solvent extraction (Schügerl, 1994), ion exchange (Vaccari et al, 1993), ultrafiltration membranes, electrodialysis (Bruno et al, 2004;Nomura et al, 1987), and crystallization (Takamatsu and Ryu, 1988). For example, in order to enhance the pyruvate production by E. coli, a fully integrated continuous process with electro-dialysis was developed to separate pyruvate from fermentation broth, so that a high pyruvate concentration of 79 g/L was achieved (Bruno et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of pyruvate production by osmotic‐tolerant mutant of Torulopsis glabrata

Liu

et al. 2007

Biotech & Bioengineering

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Pyruvate production by Torulopsis glabrata was used as a model to study the mechanism of product inhibition and the strategy for enhancing pyruvate production. It was found that the concentration of cell growth and pyruvate deceased with the increase of NaCl and sorbitol concentrations. To enhance the osmotic stress resistance of the strain, an NaCl-tolerant mutant RS23 was screened and selected through a pH-controlled continuous culture with 70 g/L NaCl as the selective criterion. Compared with the parent strain, mutant RS23 could grow well on the medium containing 70 g/L NaCl or 0.6 mol/L sorbitol. Pyruvate concentration by the mutant strain RS23 reached 94.3 g/L at 82 h (yield on glucose 0.635 g/g) in a 7-l fermentor with 150 g/L glucose as carbon source. Pyruvate concentration and yield of mutant RS23 were 41.1% and 11.1% higher than those of the parent strain, respectively. The strategy for enhancing pyruvate production by increasing osmotic stress resistance may provide an alternative approach to enhance organic acids production with yeast.

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“…However, the fouling of anion-exchange membranes by cells was observed in electrodialysis fermentation. To solve this problem, NOMURA et al (1987) used immobilized growing cells entrapped in calcium alginate. The amount of lactic acid produced by semicontinuous electrodialysis fermentation using immobilized cells was 8-times higher than that produced by non-pH controlled fermentation, but some free cells were determined in the solution.…”

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Application of electrodialysis for lactic acid recovery

Hábová¹,

Melzoch²,

Rychtera³

et al. 2001

Czech J. Food Sci.

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The paper deals with the possibility of using two-stage electrodialysis for recovery of lactic acid from model solutions and from fermentation broth. In the first step lactate was concentrated with desalting electrodialysis using ion exchange membranes Ralex (Mega, Czech Republic). The highest final concentration of 111 g/l was reached in the concentrate, it means an increase more than 2.5-times in comparison with the initial concentration. At the most 2 g of lactate per litre remained in the feed. The second step was the electroconversion of sodium lactate to lactic acid by water-splitting electrodialysis with the bipolar membranes Neosepta (Tokuyama Corp., Japan). The final lactic acid concentration of 157 g/l was reached in the diluate. Total required energy in both electrodialysis processes consisting of the energy consumption for lactate transfer and for its electroconversion to lactic acid was 142 Wh/mol. The fermentation broth was decolourised before electrodialysis experiments. The best decolourisation capacity was shown by granulated active charcoal filled in the column operated by a slow flow of broth.

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Lactic acid production by electrodialysis fermentation using immobilized growing cells

Cited by 91 publications

References 12 publications

L(+)-Lactic acid recovery from cassava bagasse based fermented medium using anion exchange resins

L(+)-Lactic acid recovery from cassava bagasse based fermented medium using anion exchange resins

Enhancement of pyruvate production by osmotic‐tolerant mutant of Torulopsis glabrata

Application of electrodialysis for lactic acid recovery

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