Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis

Abstract

Deficient deposition of X-rays and strong capacity of repairing damage DNA of cancer cells limit the effect of radiation therapy (RT). Herein, we synthesize CsLu2F7 nanoparticles with lactic acid (LA) ligands (CsLu2F7-LA) to overcome these limitations. The high-Z atoms of Lu and Cs can deposit more X-rays for generating enhanced hydroxyl radicals (·OH). Meanwhile, the LA ligand will guide CsLu2F7-LA to target monocarboxylic acid transporter (MCT) and impede the transportation of free LA, leading to decreased glycolysis and DNA damage repair. Consequently, the curative effect of RT will be enhanced and the strategy of LA accumulation induced radiosensitization is proved by in vivo and in vitro experiments, which will bring prospects for enhanced RT with nanomedicine.

Theranostic applications of selenium nanomedicines against lung cancer

“…[ 199 – 203 ]. In most cases, RT is a form of therapy that employs IR, which is typically used to describe high-energy photon radiation, such as X-rays and gamma (g) rays, as well as particle radiation such as alpha or beta particles, carbon ions, electron, proton, or neutron beams [ 204 – 206 ]. IR has the ability to disrupt biomolecules directly, including proteins, lipids, and DNA.…”