Lactic acid-induced modifications in films of Eudragit RL and RS aqueous dispersions

Omari, Derar M.; Sallam, Al-Sayed; Abdelbary, Ahmed; El-Samaligy, Mohamed S.

doi:10.1016/j.ijpharm.2004.01.004

Cited by 27 publications

(18 citation statements)

References 27 publications

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“…All concentrations were calculated as percent w/w based on the dry polymer weight multiplied by the cross-head speed (mm/s) divided by the cross-sectional area of the film (22). An additional parameter, the tensile strength/Young's modulus ratio (σ/E) was also calculated as an indication of the crack resistance of the films (29).…”

Section: Mechanical Testing Of the Filmsmentioning

confidence: 99%

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

et al. 2015

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Abstract. Antiadherents are used to decrease tackiness of a polymer coating during both processing and subsequent storage. Despite being a common excipient in coating formulae, antiadherents may affect mechanical properties of the coating film as well as drug release from film-coated tablets, but how could addition of antiadherents affect these properties and to what extent and is there a relation between the physical characteristics of the tablet coat and the drug release mechanisms? The aim of this study was to evaluate physical characteristics of films containing different amounts of the antiadherents talc, glyceryl monostearate, and PlasACRYL TM T20. Eudragit RL30D and Eudragit RS30D as sustained release polymers and Eudragit FS30D as a delayed release material were used. Polymer films were characterized by tensile testing, differential scanning calorimetry (DSC), microscopic examination, and water content as calculated from loss on drying. The effect of antiadherents on in vitro drug release for the model acetylsalicylic acid tablets coated with Eudragit FS30D was also determined. Increasing talc concentration was found to decrease the ability of the polymer films to resist mechanical stress. In contrast, glyceryl monostearate (GMS) and PlasACRYL produced more elastic films. Talc at concentrations higher than 25% caused negative effects, which make 25% concentration recommended to be used with acrylic polymers. All antiadherents delayed the drug release at all coating levels; hence, different tailoring of drug release may be achieved by adjusting antiadherent concentration with coating level.

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Section: Mechanical Testing Of the Filmsmentioning

confidence: 99%

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

et al. 2015

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“…The advantages of this polymer include pH-independent release profiles; encapsulation of high amount of drug; release of the incorporated drug in controlled manner and high level of stability (Kishori et al, 2013;Momoh et al, 2014). Eudragit Õ RS 100 is insoluble in water but swells in digestive fluid independently of the pH value (Omari et al, 2004), thus represents the characteristics of a beneficial material for the controlled oral administration of drugs (Castelli et al, 2002;Mateovic-Rojnik et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery

Öz

Devrim

Bozkır

et al. 2015

Journal of Microencapsulation

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Effective clinical utilisation of non-steroidal anti-inflammatory drugs, such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration. The objective of this work was to develop reconstitutable pediatric suspensions of DS-loaded microspheres prepared with an acrylic polymer (Eudragit RS) for improved pediatric delivery of DS. The microspheres were prepared by the water-in-oil-in-water or solid-in-oil-in-water emulsion techniques. Enviromental scanning electron microscopy observations clearly showed that microspheres have spherical shape. The drug entrapment efficiency of these microspheres was found 47.96 ± 0.79% to 88.57 ± 0.59% and their average particle sizes were 23.94-60.78 µm, which are within the desired range for the development of suspension formulation. The in vitro dissolution indicated prolonged sustained release of DS over 8 h. The results of preliminary characterisation studies of suspensions show that a liquid pharmaceutical preparation for oral administration capable of providing a sustained release of DS was successfully obtained.

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“…It is insoluble in water but swells in the digestive fluid, independent of the pH and become permeable. It is used mainly in film coating of tablets, granules, and other small particles and could be used in matrix formulation as well (17). Eudragit nanoparticles appear as suitable inert carriers for oral drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Eudragit-Based Nanosuspension of Poorly Water-Soluble Drug: Formulation and In Vitro–In Vivo Evaluation

Yadav

Mishra²,

Mishra

2012

AAPS PharmSciTech

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Abstract. The present study was performed to investigate potential of Eudragit RLPO-based nanosuspension of glimepiride (Biopharmaceutical Classification System class II drug), for the improvement of its solubility and overall therapeutic efficacy, suitable for peroral administration. Nanoprecipitation method being simple and less sophisticated was optimized for the preparation of nanosuspension. Physicochemical characteristics of nanosuspension in terms of size, zeta potential, polydispersity index, entrapment efficiency (% EE) and in vitro drug release were found within their acceptable ranges. The size of the nanoparticles was most strongly affected by agitation time while % EE was more influenced by the drug/polymer ratio. Differential scanning calorimetry and X-ray diffraction studies provided evidence that enhancement in solubility of drug resulted due to change in crystallinity of drug within the formulation. Stability study revealed that nanosuspension was more stable at refrigerated condition with no significant changes in particle size distribution, % EE, and release characteristics for 3 months. In vivo studies were performed on nicotinamide-streptozotocin-induced diabetic rat models for pharmacokinetic and antihyperglycaemic activity. Nanosuspension increased maximum plasma concentration, area under the curve, and mean residence time values significantly as compared to aqueous suspension. Oral glucose tolerance test and antihyperglycaemic studies demonstrated plasma glucose levels were efficiently controlled in case of nanosuspension than glimepiride suspension. Briefly, sustained and prolonged activity of nanosuspensions could reduce dose frequency, decrease drug side effects, and improve patient compliance. Therefore, glimepiride nanosuspensions can be expected to gain considerable attention in the treatment of type 2 diabetes mellitus due to its improved therapeutic activity.

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Lactic acid-induced modifications in films of Eudragit RL and RS aqueous dispersions

Cited by 27 publications

References 27 publications

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery

Eudragit-Based Nanosuspension of Poorly Water-Soluble Drug: Formulation and In Vitro–In Vivo Evaluation

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