Lactic Acid Dehydrogenase in Vitamin B&lt;sub&gt;12&lt;/sub&gt; Deficiency

Gordin, Ruben; Enari, Tor-Magnus

doi:10.1159/000205652

Cited by 22 publications

(3 citation statements)

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“…18 A correlation between reticulocytosis and decreasing LDH activity, followed later by rise in haemoglobin has been found in few studies. 19,20 In present study too, there is a significant difference between LDH values before and after treatment. Jaswal et al stated that raised serum LDH levels were seen in all types of macrocytic anaemia, but serum total LDH values >3000IU/L are diagnostic of megaloblastic anaemia and values between 451-3000 IU/L can be seen in megaloblastic anaemia with early megaloblastic change, dimorphic anaemia and hemolytic anemia.…”

Section: Discussionsupporting

confidence: 48%

Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia

et al. 2016

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Section: Discussionsupporting

confidence: 48%

Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia

et al. 2016

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“…Values as high as 28, 125 units/L have been reported and the serum LDH values reduced after treatment [6]. A correlation between reticulocytosis and decreasing LDH activity, followed later by rise in haemoglobin has been found in few studies [7,8].…”

Section: Discussionmentioning

confidence: 98%

Evaluation of serum LDHlevels in the diagnosis and inmonitoring the response to the treatment in children with megaloblastic anaemia

Kumar¹,

Mirji²

2019

Int J Pediatr Res

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Background: Megaloblastic anaemia is still a common and preventable cause of anaemia in children.Invasive procedure like bone marrow examination and expensive investigation like estimation of serum vitamin B12 and folic acid levels are the definitive diagnostic tools. Their non availability at peripheral centre lead to a great deal of interest in other simple biochemical investigations like estimation of serum LDH levels. Design/methods: Children aged between 6 months to 14 yrs with clinically suspected megaloblastic anaemia formed the study group. A detailed clinical history and examination was done. All subjects had complete blood counts. Serum LDH levels, serum levels of vitamin B12 and folic acid levels were done. Serial measurements of serum LDH levels were done on day 14 and day 30 of treatment and were correlated with the haemoglobin and MCV levels. Results: A total of 48 patients formed the study group. All cases were anaemic with mean HB level of 5.25g/dl, mean MCV was 100.15fl. All cases had megaloblastic changes on peripheral smear.42 cases had low vitamin B12 levels and 6 cases had low folic acid levels. Serum LDH levels were elevated in all cases with mean level of 3423 IU/L. There was a significant negative correlation between HB levels and serum LDH levels (r = -.923, p<0.001) a significant positive correlation between MCV and serum LDH levels(r = +0.810, p<0.001). One month after treatment HB levels and MCV improved (mean HB-10.3g/dl and mean MCV-88.3fl/l). There was also a significantly fall in the serum levels of LDH 14 days and one month after treatment (p<0.001, p<0.001 respectively). Conclusion: Serum LDH levelis an important investigation in the diagnosis and in monitoring the response to treatment in megaloblastic anaemia.

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“…Ύπεστηρίχθη 63 οτι κυρίαν πηγήν του ενζύμου αποτελεί ή ηύξημένη καταστροφή τών περιφερικών έρυθροκυττάρων, ήτις πράγματι επιτελείται ταχύτερον επί μεγαλοβλαστικής αναιμίας 39 . Ό ρυθμός όμως τής περιφερι κής ταύτης αίμολύσεως, τριπλάσιος απλώς του φυσιολογικού 64 , δέν επαρ κεί προς έξήγησιν τής υπέρογκου αυξήσεως τής LDH του όρου 65 , 66 , ως συνάγεται έξ άλλου καί εκ τής ανευρέσεως φυσιολογικών σχεδόν επιπέ δων άπτοσφαιρινων εις τον όρόν, δηλούντων μικράν αίμόλυσιν 67 . Σημει ωτέον, προς τούτοις, οτι ή περιεκτικότης εϊς LDH τών περιφερικών έρυ θροκυττάρων δέν άνευρέθη ηύξημένη επί μεγαλοβλαστικής αναιμίας 48 , 51 εν συγκρίσει προς τήν περιεκτικότητα τών φυσιολογικών έρυθροκυττάρων.…”

Section: Discussionunclassified

Μεταβολαι Της Εν Τω Ορω Δραστικοτητος Της Γαλακτικης Αφυδρογονασης (Ldh) Επι Νοσων Του Αιματος

Γεωργιαδησ¹

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σκαλον κ. Γεώργιον Γιαννακούρην, χάρις εις τήν συνεχή καθοδήγησιν, τήν ενεργον συμπαράστασιν καί την εποικοδομητικήν κριτικήν τον οποίου κατέ στη δυνατή ή έκπόνησις τής παρούσης μελέτης. Τον Διευθυντήν του Κέντρου Αιμοδοσίας κ. Ήλίαν Πολίτην θερμώς ευχαριστώ δια τήν αημαντικήν βοήθειαν, ην προθύμως μοϊ παρέσχε, δια του πλήρους αιματολογικού ελέγχου τών μελετηθέντων ασθενών. 'Εκφράζω ωσαύτως τάς ευχαριστίας μου προς τον Έπιμελητήν τής Κλινικής κ. Νικόλαον Μπαμπούρην δια τήν συμπαράστασιν του, προς τον φίλον συνάδελφον κ. Άνδρέαν Σταθόπουλον δια τήν πρόθυμον και επιδεξίαν συμβολήν του εις τήν επιτυχή απόδοσιν τών εικόνων καί πινάκων, ώς και προς τήν παρασκευάστριαν τον βιοχημικού εργαστηρίου τής Κλινικής ,δίδα ΑΙμιλίαν Βολάκη δια τήν πρόθυμον βοήθειαν της.

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Lactic Acid Dehydrogenase in Vitamin B<sub>12</sub> Deficiency

Cited by 22 publications

References 3 publications

Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia

Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia

Evaluation of serum LDHlevels in the diagnosis and inmonitoring the response to the treatment in children with megaloblastic anaemia

Μεταβολαι Της Εν Τω Ορω Δραστικοτητος Της Γαλακτικης Αφυδρογονασης (Ldh) Επι Νοσων Του Αιματος

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