Lactic acid bacterial exopolysaccharides strongly bind histamine and can potentially be used to remove histamine contamination in food

Abstract

The symptoms of foodborne histamine poisoning are similar to those of IgE-mediated food allergies. In this study, we investigated the histamine-binding capacity of lactic acid bacteria (LAB) strains as potential preventive agents against histamine poisoning. Histamine biosorption capacity was determined for 16 LAB strains. Leuconostoc mesenteroides TOKAI 51 m, Lactobacillus paracasei TOKAI 65 m, Lactobacillus plantarum TOKAI 111 m and Pediococcus pentosaceus TOKAI 759 m showed especially high biosorption rates and reached saturation within 30 min. Adsorption isotherms showed better conformance to the Freundlich model than to the Langmuir model. Analyses after heat, periodic acid and guanidine hydrochloride treatments suggested that histamine was bound to the bacterial cell surface. HPLC analysis revealed that exopolysaccharides produced by Lact. paracasei TOKAI 65 m strongly bound to histamine. In the detachment test with 1 mol l−1 HCl solution, the dissociation rate of histamine for Lact. paracasei TOKAI 65 m was <10 %. This strain is presumably a suitable candidate for use against histamine poisoning.

Evaluation of Neuro-Hormonal Dynamics after the Administration of Probiotic Microbial Strains in a Murine Model of Hyperthyroidism

“…This potential allergenic effect of L. acidophilus is aligned with other studies that recognise Lactobacillus strains as being producers of this biogenic amine [78,79]. On the other hand, numerous studies confirm the ability of Lactobacillus bacteria to avoid allergic reactions through mechanisms like binding histamine, making these probiotics suitable candidates against histamine poisoning [80]. Additional research is required to draw a definitive conclusion regarding the involvement of Lactobacillus strains in allergic reactions.…”

Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy

“…Histamine, a canonical feature of allergic response, can be bound and depleted by lactic acid bacteria, including Lactobacillus strains. 45 , 46 Tryptophan has been shown to be elevated in asthmatic children 47 ; its degradation through the mammalian indoleamine 2,3-dioxygenase (IDO) is known to promote resolution of chronic inflammation. 48 These data point to the underexplored role of heritable microbes in assembly of the early-life gut microbiome and their functional features that program immune function in early life.…”