Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges

Villena, Julio; Oliveira, Maria Leonor S.; Ferreira, Patrícia C.D.; Salva, Susana; Alvarez, Susana

doi:10.1016/j.intimp.2011.06.004

Cited by 66 publications

(63 citation statements)

References 115 publications

(249 reference statements)

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“…Moreover, L. rhamnosus CRL1505 nasal treatment increased the number and functionality of respiratory B cells, which would be of great importance considering the high incidence of respiratory infections in immunocompromised hosts, including those associated to malnutrition states. Some works evaluated the effect of probiotics on the gut-associated lymphoid tissue and the stimulation of the common mucosal immune system to improve immunity against respiratory pathogens and for the recovery of lung immunity in malnourished hosts (7,13). We showed that other important inductive sites for mucosal B cell recovery using immunobiotics are bronchusassociated lymphoid tissue and naso-pharynx-associated lymphoid tissue.…”

Section: Discussionmentioning

confidence: 97%

“…Our previous studies in immnunocompetent mice demonstrated that nasally administered LAB induce systemic and respiratory immune responses superior to those obtained using oral stimulation (13). Therefore, in this work, we evaluated the effect of nasally administered L. rhamnosus CRL1505 to improve respiratory defenses during recovery in malnourished mice.…”

Section: Discussionmentioning

confidence: 97%

“…Considering that nasally administered antigens can induce respiratory and systemic immune responses superior to those obtained using oral stimulation (12), researchers more recently focused on the ability of nasal stimulation with immunobiotics to improve respiratory immune responses (13). Some studies demonstrated that nasal administration of LAB is able to improve respiratory immunity and significantly increase the resistance of immunocompetent mice against influenza virus (14), S. pneumoniae (15), and lethal pneumovirus infections (16).…”

Section: Introductionmentioning

confidence: 99%

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Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Barbieri

Villena

Herrera

et al. 2013

The Journal of Nutrition

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The ability of nasally administered Lactobacillus rhamnosus CRL1505 to accelerate the recovery of respiratory B cell-mediated immunity against pneumococcal infection in replete malnourished mice was evaluated. Weaned mice were malnourished after consumption of a protein-free diet for 21 d. Malnourished mice were fed a balanced conventional diet (BCD) for 7 d (BCD group) or a BCD for 7 d with supplemental L. rhamnosus CRL1505 by the nasal route during the last 2 d (BCD+Lr group). Nonreplete malnourished and normal mice were used as the malnourished (MNC) and the well-nourished (WNC) control groups, respectively. Mice were challenged with Streptococcus pneumoniae at the end of each dietary treatment. The immune response was studied before the challenge and at different times postinfection. The MNC mice had less resistance to pneumococcal infection, fewer mature and immature B cells in lung and spleen, and a reduced production of specific antibodies compared with WNC mice. The BCD treatment did not induce a complete normalization of the number B cell populations and antibody amounts. However, the BCD+Lr group had normal numbers of spleen and lung B cells. Moreover, the BCD+Lr mice had a significantly lower susceptibility to S. pneumoniae infection and higher amounts of anti-pneumococcal antibodies. Although further studies are necessary to clarify the effect of malnutrition and nasally administered lactobacilli in other immune cell populations involved in the protection against respiratory pathogens, this work gives evidence of the importance of using nasal priming with probiotics to accelerate the recovery of respiratory immunity in immunocompromised malnourished hosts.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Barbieri

Villena

Herrera

et al. 2013

The Journal of Nutrition

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“…Some few studies reported that nasally administered heat-killed immunobiotics are capable of improving resistance against respiratory pathogens (50, 61, 84, 85) (Table 1). In this regard, studies by Hori et al (50) showed that the nasal priming with heat-killed L. casei Shirota significantly augmented the resistance of adult BALB/c mice to influenza virus by stimulating respiratory tract cellular immunity.…”

Section: Local Modulation Of Respiratory Anti-viral Immunity By L Rhmentioning

confidence: 99%

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

Kitazawa

Villena

2014

Front. Immunol.

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Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants and young children. Host immune response is implicated in both protective and immunopathological mechanisms during RSV infection. Activation of Toll-like receptor (TLR)-3 in innate immune cells by RSV can induce airway inflammation, protective immune response, and pulmonary immunopathology. A clear understanding of RSV–host interaction is important for the development of novel and effective therapeutic strategies. Several studies have centered on whether probiotic microorganisms with the capacity to stimulate the immune system (immunobiotics) might sufficiently stimulate the common mucosal immune system to improve defenses in the respiratory tract. In this regard, it was demonstrated that some orally administered immunobiotics do have the ability to stimulate respiratory immunity and increase resistance to viral infections. Moreover, during the last decade scientists have significantly advanced in the knowledge of the cellular and molecular mechanisms involved in the protective effect of immunobiotics in the respiratory tract. This review examines the most recent advances dealing with the use of immunobiotic bacteria to improve resistance against viral respiratory infections. More specifically, the article discuss the mechanisms involved in the capacity of the immunobiotic strain Lactobacillus rhamnosus CRL1505 to modulate the TLR3-mediated immune response in the respiratory tract and to increase the resistance to RSV infection. In addition, we review the role of interferon (IFN)-γ and interleukin (IL)-10 in the immunoregulatory effect of the CRL1505 strain that has been successfully used for reducing incidence and morbidity of viral airways infections in children.

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“…23 Immune effects of probiotics may be species-or strain-rather than genus-specific. 24,25 It is also possible that publication bias, which is difficult to assess in meta-analyses of small numbers of studies, or time-lag bias may have contributed to the Cochrane review's findings. 26 We identified a data-entry error in the 2011 Cochrane review and an issue of differential loss to follow-up-an assumption that the 18.3% in the probiotic group and 4.6% in the control group who were lost to follow-up would all have had no URTIsboth relating to the included studies of Hao et al 2 and Cobo Sanz et al 27 (Supplemental Appendix 7, http:// www.annfammed.org/content/14/5/422/suppl/DC1).…”

Section: Discussionmentioning

confidence: 99%

Recommending Oral Probiotics to Reduce Winter Antibiotic Prescriptions in People With Asthma: A Pragmatic Randomized Controlled Trial

Smith

Watt

Gunn

et al. 2016

The Annals of Family Medicine

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PURPOSE Evidence from studies mainly in children has shown that orally administered probiotics may prevent respiratory tract infections and associated antibiotic use. We evaluated whether advice to take daily probiotics can reduce antibiotic prescribing for winter respiratory tract infections in people with asthma. METHODSWe conducted a randomized controlled, parallel-group pragmatic study for participants aged 5 years and older with asthma in a UK primary care setting. The intervention was a postal leaflet with advice to take daily probiotics from October 2013 to March 2014, compared with a standard winter advice leaflet. Primary outcome was the proportion of participants prescribed antibiotics for respiratory tract infections. RESULTSThere were 1,302 participants randomly assigned to a control group (n = 650) or intervention group (n = 652). There was no significant difference in the primary outcome measure, with 27.7% receiving antibiotics in the intervention group and 26.9% receiving antibiotics in the control group (odds ratio = 1.04; 95% CI, 0.82-1.34). Uptake of probiotics was low, but outcomes were similar in those who accessed probiotics (adjusted odds ratio = 1.08; 95% CI, 0.69-1.69, compared with controls). We also found no evidence of an effect on respiratory tract infections or asthma exacerbations. CONCLUSIONSIn this pragmatic community-based trial in people with asthma, we found no evidence that advising use of winter probiotics reduces antibiotic prescribing.

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Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges

Cited by 66 publications

References 115 publications

Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Nasally Administered Lactobacillus rhamnosus Accelerate the Recovery of Humoral Immunity in B Lymphocyte-Deficient Malnourished Mice

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

Recommending Oral Probiotics to Reduce Winter Antibiotic Prescriptions in People With Asthma: A Pragmatic Randomized Controlled Trial

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