Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Zhang, Tong; Liu, Wenxu; Lu, Huimin; Cheng, Ting; Wang, Linlin; Wang, Gang; Zhang, Hao; Chen, Wei

doi:10.1080/10408398.2023.2278155

Cited by 1 publication

(1 citation statement)

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“…We concluded that dysbiosis is a possible mechanism behind constipation, but we did not perform an analysis of the composition of the intestinal microbiota. Another limitation may be the non-homogenous age of patients, as menopausal symptoms may be age-dependent [ 65 ]. The same concerns obesity, because vasomotor symptoms frequently experienced by women have been associated with obesity, and it is suggested that weight management efforts may reduce the severity of menopausal symptoms [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Tryptophan Metabolism in Postmenopausal Women with Functional Constipation

Blonska,

Chojnacki,

Macieja

et al. 2023

IJMS

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Constipation belongs to conditions commonly reported by postmenopausal women, but the mechanism behind this association is not fully known. The aim of the present study was to determine the relationship between some metabolites of tryptophan (TRP) and the occurrence and severity of abdominal symptoms (Rome IV) in postmenopausal women with functional constipation (FC, n = 40) as compared with age-adjusted postmenopausal women without FC. All women controlled their TRP intake in their daily diet. Urinary levels of TRP and its metabolites, 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), and 3-indoxyl sulfate (indican, 3-IS), were determined by liquid chromatography/tandem mass spectrometry. Dysbiosis was assessed by a hydrogen–methane breath test. Women with FC consumed less TRP and had a lower urinary level of 5-HIAA, but higher levels of KYN and 3-IS compared with controls. The severity of symptoms showed a negative correlation with the 5-HIAA level, and a positive correlation with the 3-IS level. In conclusion, changes in TRP metabolism may contribute to FC in postmenopausal women, and dysbiosis may underlie this contribution.

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Section: Discussionmentioning

confidence: 99%