Lactic acid bacteria as a cell factory for riboflavin production

Thakur, Kiran; Tomar, Sudhir Kumar; De, Sachinandan

doi:10.1111/1751-7915.12335

Cited by 151 publications

(109 citation statements)

References 78 publications

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“…Successional interactions among members in a microbial community (as described in part a ) depend on the exchange of amino acids and vitamins. L. paracasei provides riboflavin (vitamin B 2 ) 93 for F. prausnitzii . Moreover, the arginine (Arg) prototroph F. prausnitzii supplies arginine for L. paracasei and B. vulgatus , which are both arginine auxotrophs.…”

Section: Figmentioning

confidence: 99%

The social network of microorganisms — how auxotrophies shape complex communities

2018

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Microorganisms engage in complex interactions with other organisms and their environment. Recent studies have shown that these interactions are not limited to the exchange of electron donors. Most microorganisms are auxotrophs, thus relying on external nutrients for growth, including the exchange of amino acids and vitamins. Currently, we lack a deeper understanding of auxotrophies in microorganisms and how nutrient requirements differ between different strains and different environments. In this Opinion article, we describe how the study of auxotrophies and nutrient requirements among members of complex communities will enable new insights into community composition and assembly. Understanding this complex network over space and time is crucial for developing strategies to interrogate and shape microbial communities.

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Section: Figmentioning

confidence: 99%

The social network of microorganisms — how auxotrophies shape complex communities

2018

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“…Humans acquire riboflavin (vitamin B 2 ) both through their diet and from riboflavin-producing gut microbes. The machinery required for riboflavin synthesis has been found in the genomes of most Bacteroidetes, Fusobacteria, and Proteobacteria examined, while a complete riboflavin operon was only present in about half of the Firmicutes and almost no Actinobacteria (44, 61). Riboflavin can be used as a redox mediator by Faecalibacterium prausnitzii to facilitate extracellular electron transfer, which consequently promotes its growth (34).…”

Section: Gwas Reveal Tissues Pathways and Genes Consistently Associmentioning

confidence: 99%

The Relationship Between the Human Genome and Microbiome Comes into View

et al. 2017

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The microbiome’s involvement in health and disease, and the complexity of its composition and function, make it intriguing to consider human genetic factors that impact microbiome composition. Genes may influence health through their ability to promote a stable microbial community in the gut. Studies of heritability yield a consistent subset of microbes that are impacted by genes, but the use of genome-wide association studies (GWAS) to identify specific genetic variants associated with microbiota phenotypes has proven challenging. Processing microbiome datasets into traits to be modeled and reducing the burden of multiple testing are just some of the technical hurdles in microbiome GWAS. Studies to date are small by GWAS standards, making cross-study comparisons and validations particularly important in identifying authentic signals. Cross-study comparisons are hampered by differences in analytical approaches. Nevertheless, some consistent associations have emerged between populations, most notably between Bifidobacteria and the lactase non-persister genotype. These early successes open the way for the microbiome to be incorporated into studies that quantify interactions among genotype, environment, and the microbiome for predicting disease susceptibility.

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“…mineral precipitation and dissolution) and climate change (Warren and Kauffman, ; Jorgensen et al ., ; Prokopenko et al ., ; Wagner, ; Wegener et al ., ; Dang and Lovell, ; Zhang et al ., ). Furthermore, interkingdom consortia have been widely found and extensively studied in the human body, such as biofilms in the oral cavity and human gut commensal microbiota (Thakur et al ., ; Zuñiga et al ., ).…”

Section: Importance Of Interkingdom Microbial Consortiamentioning

confidence: 98%

Interkingdom microbial consortia mechanisms to guide biotechnological applications

Shu

Merino

Okamoto

et al. 2018

Microbial Biotechnology

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SummaryMicrobial consortia are capable of surviving diverse conditions through the formation of synergistic population‐level structures, such as stromatolites, microbial mats and biofilms. Biotechnological applications are poised to capitalize on these unique interactions. However, current artificial co‐cultures constructed for societal benefits, including biosynthesis, agriculture and bioremediation, face many challenges to perform as well as natural consortia. Interkingdom microbial consortia tend to be more robust and have higher productivity compared with monocultures and intrakingdom consortia, but the control and design of these diverse artificial consortia have received limited attention. Further, feasible research techniques and instrumentation for comprehensive mechanistic insights have only recently been established for interkingdom microbial communities. Here, we review these recent advances in technology and our current understanding of microbial interaction mechanisms involved in sustaining or developing interkingdom consortia for biotechnological applications. Some of the interactions among members from different kingdoms follow similar mechanisms observed for intrakingdom microbial consortia. However, unique interactions in interkingdom consortia, including endosymbiosis or interkingdom‐specific cell–cell interactions, provide improved mitigation to external stresses and inhibitory compounds. Furthermore, antagonistic interactions among interkingdom species can promote fitness, diversification and adaptation, along with the production of beneficial metabolites and enzymes for society. Lastly, we shed light on future research directions to develop study methods at the level of metabolites, genes and meta‐omics. These potential research methods could lead to the control and utilization of highly diverse microbial communities.

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Lactic acid bacteria as a cell factory for riboflavin production

Cited by 151 publications

References 78 publications

The social network of microorganisms — how auxotrophies shape complex communities

The social network of microorganisms — how auxotrophies shape complex communities

The Relationship Between the Human Genome and Microbiome Comes into View

Interkingdom microbial consortia mechanisms to guide biotechnological applications

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