Lactational exposure of polybrominated diphenyl ethers and its association with infant developmental measurements

Li, Jialin; Ma, Wenjuan; Zhao, Yingya; Jin, Yuting; Xiao, Xirong; Ge, Wenzhen; Shi, Huijing; Zhang, Yunhui

doi:10.1016/j.jhazmat.2020.122031

Cited by 15 publications

(5 citation statements)

References 42 publications

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“…These disparities can be due to differences in how thyroid hormones act in women and men [108]. Other conflicting results were found when comparing our review results to previous research regarding aspects such as birth length, in which a decrease was associated with PBDE exposure [91,98,100,104]. An increase in gestational age was supported by Chen et al [98], but Eick et al [94] and Jin et al [91] observed a negative association with PBDE exposure.…”

Section: Reproductive Healthcontrasting

confidence: 64%

“…There were conflicting results observed for head circumference with other studies. Li et al [104], Miranda et al [105], and Lopez-Espinosa et al [99] observed a decrease, while Yin et al [106] and Chen et al [107] observed an increase associated with PBDE exposures. Robledo Candace et al [100] identified sex-specific differences in neonates, in which head circumference and birth weight associated with PBDEs were lower in girls and higher in boys.…”

Section: Reproductive Healthmentioning

confidence: 97%

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Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review

Singh

Cortes-Ramirez

Toms

et al. 2022

IJERPH

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Electronic waste management is a global rising concern that is primarily being handled by informal recycling practices. These release a mix of potentially hazardous chemicals, which is an important public health concern. These chemicals include polybrominated diphenyl ethers (PBDEs), used as flame retardants in electronic parts, which are persistent in nature and show bioaccumulative characteristics. Although PBDEs are suspected endocrine disruptors, particularly targeting thyroid and reproductive hormone functions, the relationship of PBDEs with these health effects are not well established. We used the Navigation Guide methodology to conduct a systematic review of studies in populations exposed to e-waste to better understand the relationships of these persistent flame retardants with hormonal and reproductive health. We assessed nineteen studies that fit our pre-determined inclusion criteria for risk of bias, indirectness, inconsistency, imprecision, and other criteria that helped rate the overall evidence for its quality and strength of evidence. The studies suggest PBDEs may have an adverse effect on thyroid hormones, reproductive hormones, semen quality, and neonatal health. However, more research is required to establish a relationship of these effects in the e-waste-exposed population. We identified the limitations of the data available and made recommendations for future scientific work.

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Section: Reproductive Healthcontrasting

confidence: 64%

Section: Reproductive Healthmentioning

confidence: 97%

Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review

Singh

Cortes-Ramirez

Toms

et al. 2022

IJERPH

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“…Burtryn et al (2020) [ 9 ] also reported higher values for BDE-47 (25.9 ng/g lipid) and ∑ PBDEs (52.9 ng/g lipid) in the United States. In China, Li et al (2020) [ 43 ] determined high levels of ∑ PBDEs (39.56 ng/g lipid) in breast milk samples. Even with the ban on the use of PBDEs in the USA and China, the high values can be justified by the high environmental persistence of these compounds.…”

Section: Resultsmentioning

confidence: 99%

Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake

Souza

Devóz

Ximenez

et al. 2022

IJERPH

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Polybrominated diphenyl ethers (PBDEs) are ubiquitous flame retardants and are environmentally persistent. PBDEs show endocrine disruption, neurotoxicity, and lower birth weight in infants, and their human body burden has become a public health concern. The infants’ exposure begins in the prenatal period and continues via breast milk ingestion, although, little is known about the factors that may influence this exposure. In this study, PBDE levels in Brazilian breast milk were assessed in 200 lactating women. The risk assessment of infants’ exposure to PBDE was performed through the estimated daily intake (EDI) calculation. The geometric mean (GM) of ∑PBDEs levels was 2.33 (0.14–6.05) ng/g wet weight. At least one PBDE congener was detected in the samples, and the 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) showed a 100% of detection rate (GM of 1.05 ng/g). Location of residence, maternal level education, monthly salary, and race were positively associated with PBDE levels (p < 0.05). The EDI of BDE-47 was higher in Belo Horizonte (8.29 ng/kg/day) than in Viçosa (6.36 ng/kg/day), as well as for the ∑PBDEs (19.77 versus 12.78 ng/kg/day) (p < 0.05). Taking the high detection rate of PBDEs in breast milk and their toxicity, continuous studies on infant exposure, fetal growth, and child neurodevelopment are requested.

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“…The study by Gross et al (2020) described above, in a case-control study of 52 cases with overweight at 18 months and 46 control infants, did not find an association between levels of BDE-28, -47 and -99 measured in dried blood spots collected at birth and overweight at 18 months. Li, Ma, et al (2020) assessed associations between PBDEs measured in human milk samples (within 2 months after delivery) and child growth measures at 42 weeks, 6 months and 12 months of age, in 77 cases with fetal growth restriction and 159 health control births. 18 PBDEs were measured.…”

Section: Outcomes Measured Postnatally (Infancy Early Childhoodmentioning

confidence: 99%

“…Li, Ma, et al. ( 2020 ) assessed associations between PBDEs measured in human milk samples (within 2 months after delivery) and child growth measures at 42 weeks, 6 months and 12 months of age, in 77 cases with fetal growth restriction and 159 health control births. 18 PBDEs were measured.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE‐28, ‐47, ‐49, ‐99, ‐100, ‐138, ‐153, ‐154, ‐183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE‐47, ‐99, ‐153, ‐209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint‐specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

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Lactational exposure of polybrominated diphenyl ethers and its association with infant developmental measurements

Cited by 15 publications

References 42 publications

Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review

Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review

Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

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