Lactation exposure to BDE-153 damages learning and memory, disrupts spontaneous behavior and induces hippocampus neuron death in adult rats

Zhang, H; Li, Xin; Nie, Jing; Niu, Qiao

doi:10.1016/j.brainres.2013.04.014

Cited by 29 publications

(16 citation statements)

References 47 publications

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“…BDE-47 and BDE-153 changed hippocampus morphology and ultra structure in rats (He et al 2009; Zhang et al 2013). BDE-47 and BDE-99 damaged rats or mice’s neuron cytoskeletal formation and neuronal maturation by affecting Ca 2+ /calmodulin-dependent protein kinase II, synaptophysin and cytoskeletal protein expression, decreasing expressions of brain-derived neurotrophic factor and anti-apoptotic bcl-2 mRNA, and protein (Alm et al 2008; Blanco et al 2011; Viberg 2009).…”

Section: Discussionmentioning

confidence: 99%

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Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children

Zhang

Yolton

Webster

et al. 2017

Environ Health Perspect

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Background:Prenatal polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) exposures may influence children’s neurodevelopment.Objective:We examined the association of prenatal PBDE and PCB exposures with children’s reading skills at ages 5 and 8 years, Full-Scale Intelligence Quotient (FSIQ), and externalizing behavior problems at age 8 years.Methods:From 239 mother–child pairs recruited (2003–2006) in Cincinnati, Ohio, we measured maternal serum PBDE and PCB concentrations, assessed child’s reading skills using the Woodcock–Johnson Tests of Achievement III (WJ-III) at age 5 years and the Wide Range Achievement Test-4 (WRAT-4) at age 8 years, tested FSIQ using the Wechsler Intelligence Scale for Children-IV (WISC-IV), and externalizing behavior problems using the Behavioral Assessment System for Children-2 (BASC-2) at age 8 years. We used multiple linear regression to examine the association of prenatal PBDE and PCB concentrations and reading, FSIQ, and externalizing behavior problems after adjusting for covariates.Results:An increase of Sum4PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) by 10 times was not significantly associated with reading scores at age 5 years at the p = 0.05 level but was inversely associated with Reading Composite scores (β: –6.2, 95% CI: –11.7, –0.6) and FSIQ (β: –5.3, 95% CI: –10.6, –0.02) at age 8 years; it was positively associated with the score for externalizing behavior problems (β: 3.5, 95% CI: –0.1, 7.2) at age 8 years. Prenatal Sum4PCBs (PCB-118, -153, -138-158, and -180) was not significantly associated with a child’s reading skills, FSIQ, and externalizing behavior problems.Conclusion:Prenatal PBDE concentration was inversely associated with reading skills and FSIQ and positively associated with externalizing behavior problems at age 8 years. No significant associations were found in prenatal PCB concentration.Citation:Zhang H, Yolton K, Webster GM, Sjödin A, Calafat AM, Dietrich KN, Xu Y, Xie C, Braun JM, Lanphear BP, Chen A. 2017. Prenatal PBDE and PCB exposures and reading, cognition, and externalizing behavior in children. Environ Health Perspect 125:746–752; http://dx.doi.org/10.1289/EHP478

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Section: Discussionmentioning

confidence: 99%

“…Several mechanisms underlying PBDE-mediated developmental neurotoxicity have been suggested in rats and mice neonatal exposure to PBDE (Johansson et al 2008; Viberg et al 2003, 2005, 2007; Zhang et al 2013). BDE-47 and BDE-153 changed hippocampus morphology and ultra structure in rats (He et al 2009; Zhang et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children

Zhang

Yolton

Webster

et al. 2017

Environ Health Perspect

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“…In another study it was observed that the brain tissue accumulated less than 0.5% of the ingested tetrabromobisphenol A (TBBPA) and BDE-99 (Viberg and Eriksson, 2011). These compounds show a drastically lower brain uptake than ATE, BATE and DPTE but nevertheless they caused severe neuronal dysfunctions in laboratory animals (Viberg and Eriksson, 2011;von der Recke and Vetter, 2007;Zhang et al, 2013). Thus, it may be that ATE, BATE and DPTE not only pass across the blood-brain barrier to a higher degree than the other BFRs but that they are also likely to affect neuronal functions.…”

Section: Introductionmentioning

confidence: 93%

Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters

Kharlyngdoh

Pradhan

Asnake

et al. 2015

Environment International

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“…Chronic exposure of LBDEs to organisms can lead to liver tumors, developmental neurotoxicity and thyroid dysfunctions [ 12 ]. LBDEs depress thyroid development as well as the long-term learning and memory capabilities in adult rats [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Photolysis of Low-Brominated Diphenyl Ethers and Their Reactive Oxygen Species-Related Reaction Mechanisms in an Aqueous System

Wang

Zhang

et al. 2015

PLoS ONE

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To date, no report was concerned with participation of reactive oxygen species in waters during photolysis of low-brominated diphenyl ethers (LBDEs). Herein, we found that electron spin resonance (ESR) signals rapidly increased with increasing irradiation time in the solution of LBDEs and 4-oxo-TMP solutions. But this phenomenon did not occur in the presence of NaN3 (1O2 quencher) demonstrating generation of 1O2 in process of LBDEs photolysis. The indirect photolytic contribution rate for BDE-47 and BDE-28 was 18.8% and 17.3% via 1O2, and 4.9% and 6.6% via ·OH, respectively. Both D2O and NaN3 experiments proved that the indirect photolysis of LBDEs was primarily attributable to 1O2. The bimolecular reaction rate constants of 1O2 with BDE-47 and BDE-28 were 3.12 and 3.64 × 106 M-1 s-1, respectively. The rate constants for BDE-47 and BDE-28 (9.01 and 17.52 × 10−3 min-1), added to isopropyl alcohol, were very close to those (9.65 and 18.42 × 10−3 min-1) in water, proving the less indirect photolytic contribution of ·OH in water. This is the first comprehensive investigation examining the indirect photolysis of LBDEs in aqueous solution.

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Lactation exposure to BDE-153 damages learning and memory, disrupts spontaneous behavior and induces hippocampus neuron death in adult rats

Cited by 29 publications

References 47 publications

Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children

Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children

Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters

Photolysis of Low-Brominated Diphenyl Ethers and Their Reactive Oxygen Species-Related Reaction Mechanisms in an Aqueous System

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