LACTATION BIOLOGY SYMPOSIUM: Lactocrine signaling and developmental programming1,2

Bartol, F.F.; Wiley, Anne A.; Miller, Dori J.; Silva, A. J.; Roberts, K. E.; Davolt, Meghan L. P.; Chen, J. C.; Frankshun, Amy-Lynn; Camp, Meredith E.; Rahman, Kathleen M.; Vallet, J. L.; Bagnell, Carol A.

doi:10.2527/jas.2012-5764

Cited by 85 publications

(75 citation statements)

References 96 publications

(165 reference statements)

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“…Undetectable at birth [44], porcine endometrial ESR1 expression was recently documented in both stroma and nascent GE for uterine tissues obtained at 24 h postnatally [7] and is routinely identified by PND 2 [7,40]. These observations were confirmed in the present study.…”

Section: Discussionsupporting

confidence: 88%

“…Present data indicating increased stromal RXFP1 expression for lactocrine-null gilts on PND 14 are consistent with those observations. Temporospatial patterns of ESR1 expression and ESR1 immunostaining illustrated here and elsewhere [7,44] for neonatal porcine endometrium suggest the evolution of paracrine conditions necessary to support stromal-epithelial interactions regulating endometrial adenogenesis and proliferation of nascent GE [59][60][61]. Results showing that endometrial ESR1 expression is most pronounced in stroma of nursed gilts within 2 days of birth and increases in the epithelial compartment with differentiation of nascent, proliferating, ESR1 þ GE agree with the idea that stromally derived ESR1-mediated signals support epithelial proliferation [60].…”

Section: Nursing and Uterine Gland Developmentmentioning

confidence: 98%

“…Observations indicating that effects of nursing on neonatal endometrial development can be tissue compartment specific point to the importance of stromalepithelial interactions as determinants of uterine developmental trajectory. Efforts to understand how lactocrine signaling affects establishment of the uterine developmental epigenotype [7] will provide important insights into maternal programming of reproductive performance and health.…”

Section: Nursing and Uterine Gland Developmentmentioning

confidence: 99%

“…If the lactocrine hypothesis is correct, disruption of lactocrine signaling would be predicted to have long-term consequences for uterine function and fecundity. In a recent report [7], the relationship between PND 0 immunoglobulin immunocrit, a measure of colostrum intake by neonatal piglets [63], and litter size was defined using data for 381 gilts over four parities (approximately 1525 litters). As predicted by the lactocrine hypothesis, results showed that low immunocrit, indicative of minimal colostrum consumption on PND 0, was associated significantly with reduced litter size in adulthood.…”

Section: Nursing and Uterine Gland Developmentmentioning

confidence: 99%

“…Thus, nursing facilitates the fetal to neonatal transition and provides a mechanism for maternal and related environmental factors to affect neonatal growth and developmental programming [1][2][3][4][5][6][7][8]. The conserved nature of lactation [2,3] suggests that transmission of nutrients and milk-borne bioactive factors (MbFs) from mother to offspring as a consequence of nursing has provided important adaptive advantages to mammals through lactocrine regulation [7,9,10] of critical developmental events during neonatal life. Although lactation strategies vary widely among mammals, milk consumption has broad implications for development that extend beyond basic nutritional support [2,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Nursing for 48 Hours from Birth Supports Porcine Uterine Gland Development and Endometrial Cell Compartment-Specific Gene Expression1

Miller

Wiley

Chen

et al. 2013

Biology of Reproduction

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The first 2 wk of neonatal life constitute a critical period for estrogen receptor alpha (ESR1)-dependent uterine adenogenesis in the pig. A relaxin receptor (RXFP1)-mediated, lactocrine-driven mechanism was proposed to explain how nursing could regulate endometrial ESR1 and related gene expression events associated with adenogenesis in the porcine neonate during this period. To determine effects of nursing on endometrial morphogenesis and cell compartment-specific gene expression, gilts (n = 6-8/group) were assigned at birth to be either 1) nursed ad libitum for 48 h, 2) gavage fed milk replacer for 48 h, 3) nursed ad libitum to Postnatal Day (PND) 14, or 4) gavage fed milk replacer for 48 h followed by ad libitum nursing to PND 14. Uteri were collected on PND 2 or PND 14. Endometrial histoarchitecture and both ESR1 and proliferating cell nuclear antigen (PCNA) labeling indexes (LIs) were evaluated. Laser microdissection was used to capture epithelium and stroma to evaluate treatment effects on cell compartment-specific ESR1, VEGFA, and RXFP1 expression. Imposition of a lactocrine-null state by milk replacer feeding for 48 h from birth retarded endometrial development and adenogenesis. Effects of replacer feeding, evident by PND 2, were marked by PND 14 when endometrial thickness, glandularity, and gland depth were reduced. Consistently, in lactocrine-null gilts, PCNA LI was reduced in glandular epithelium (GE) and stroma on PND 14, when epithelial ESR1 expression and ESR1 LI in GE were reduced and stromal VEGFA and RXFP1 expression increased. Results establish that lactocrine signaling effects morphogenetic changes in developing uterine tissues that may determine reproductive capacity later in life.

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Section: Discussionsupporting

confidence: 88%

Section: Nursing and Uterine Gland Developmentmentioning

confidence: 98%

Section: Nursing and Uterine Gland Developmentmentioning

confidence: 99%

Section: Nursing and Uterine Gland Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nursing for 48 Hours from Birth Supports Porcine Uterine Gland Development and Endometrial Cell Compartment-Specific Gene Expression1

Miller

Wiley

Chen

et al. 2013

Biology of Reproduction

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Lactation and weaning

Quinn

2018

The International Encyclopedia of Biological Anthropology

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Lactation is one of the defining characteristics of mammals, including humans. Lactation is the direct transfer of maternal resources to offspring via a specialized substance called milk. Both the composition of milk and the characteristics (duration, frequency, intensity, etc.) of lactation are highly species specific, reflecting considerable evolutionary selection on lactation and milk. Studies of lactation by anthropologists cut across all subfields of anthropology. Within biological anthropology, lactation and milk composition have been studied in human and nonhuman primates, greatly enhancing current understanding of the central importance of lactation in these groups and the highly specialized adaptations in primates and humans for lactation. This entry briefly discusses the evolution of lactation, primate studies, and current understanding of mammary anatomy, milk synthesis, and composition. A growing body of research by anthropologists is radically reshaping our understanding of variability in the human milk phenotype and the impact such variability has on infant, and ultimately adult, development. The discussion concludes by looking at some ongoing debates about lactation in biological anthropology, including the meaning and practice of weaning in a cross‐cultural and historical perspective.

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Maternal birth weight is associated with milk epidermal growth factor in Filipino women

Kuziez

Harkey

Burack

et al. 2020

American J Hum Biol

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Objectives: Lactational programming, through which milk-borne bioactives influence both neonatal and long-term biological development, is well established. However, almost no research has investigated how developmental stimuli during a mother's early life may influence her milk bioactives in adulthood. Here, we investigated the association between maternal birth weight and milk epidermal growth factor (EGF) and epidermal growth factor receptor (EGF-R) in later life. We predicted there would be a decrease in both milk EGF and EGF-R in the milk produced by mothers who were themselves born low birth weight. Methods: Study participants are from the Cebu Longitudinal Health and Nutrition Survey. Mothers (n = 69) were followed longitudinally since birth with prospective data collection. Anthropometrics, health, and dietary recalls were collected with early morning milk samples when mothers were 24 to 25 years of age. Milk samples were analyzed for EGF and its receptor (EGF-R). Analysis of variance was used to test for differences in milk EGF and EGF-R between low and average birthweight mothers after adjustment for parity, age, and maternal dietary energy intake. Results: Mothers who were low birth weight produced milk with significantly less EGF and more EGF-R which resulted in a lower ratio of EGF to EGF-R. These associations persisted after adjustment for infant age, maternal adiposity, and dietary energy. Conclusions: While this is a small sample size, these preliminary findings suggest that maternal early life characteristics, such as birth weight, may be important contributors to variation in milk bioactives. Future work is necessary to understand how variation in maternal early life may influence milk composition in adulthood. 1 | INTRODUCTION The importance of human milk for infant growth and nutrition is well established. In addition to its role in nutrition, milk also contains numerous hormones, growth factors, and other bioactive molecules known to protect infant health and promote growth and development (Agostoni, 2005; Fields & Demerath, 2012). Among the best studied of these are the metabolic hormones, such as the adipokines leptin and adiponectin, which are

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LACTATION BIOLOGY SYMPOSIUM: Lactocrine signaling and developmental programming1,2

Cited by 85 publications

References 96 publications

Nursing for 48 Hours from Birth Supports Porcine Uterine Gland Development and Endometrial Cell Compartment-Specific Gene Expression1

Nursing for 48 Hours from Birth Supports Porcine Uterine Gland Development and Endometrial Cell Compartment-Specific Gene Expression1

Lactation and weaning

Maternal birth weight is associated with milk epidermal growth factor in Filipino women

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