Lactate: Friend or Foe

Hall, Mederic M.; Rajasekaran, Sathish; Thomsen, Timothy W.; Peterson, Andrew R.

doi:10.1016/j.pmrj.2015.10.018

Cited by 67 publications

(56 citation statements)

References 41 publications

(57 reference statements)

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“…Our observation that hearts of STAT3 KO mice treated with ANG II produce more lactate than CTRL hearts is further evidence that glycolytic flux is enhanced in these hearts as well, as increased workload on the heart eventually leads to increased Glc uptake, glycogenolysis, glycolytic flux, and pyruvate oxidation (Depre et al, 1999). Under certain conditions, enhanced glycolysis has been associated with metabolic acidosis and impaired mechanical function of the heart (Clanachan, 2006; Hall et al, 2016), and therefore may have contributed to the impaired cardiac contractility that we observed in STAT3 KO mice treated with ANG II.…”

Section: Discussionmentioning

confidence: 89%

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

et al. 2016

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Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-targeted STAT3 knockout (KO) mice and Angiotensin II (ANG II) infusion by osmotic minipumps. After 4 weeks, ANG II induced similar cardiac hypertrophy in wild type (WT) and cardiac Cre-expressing control (CTRL) mice with no impairment of cardiac function. In contrast, STAT3 KO mice exhibited reduced contractile function but similar hypertrophy to CTRL mice. Ejection fraction and fractional shortening decreased by 22.5 and 27.3%, respectively. Since STAT3 has direct protective effects on mitochondrial function, we examined rates of glucose and oleate oxidation by isolated perfused hearts using a Langendorff system. Hearts of ANG II-treated STAT3 KO and CTRL mice had similar rates of oleate oxidation as saline-infused WT mice. Rates of glucose oxidation were similar between hearts of WT plus saline and CTRL plus ANG II mice; however, glucose oxidation was increased by 66% in hearts of ANG II-treated STAT3 KO mice. The ratio of maximal ATP yield from glucose to fatty acid oxidation was 21.1 ± 3.1 in hearts of ANG II-treated STAT3 KO mice vs. 12.6 ± 2.2 in hearts of ANG II-treated CTRL mice. Lactate production was also elevated in hearts of ANG II-treated STAT3 KO mice by 162% compared to ANG II-treated CTRL mice. Our findings indicate that STAT3 is important for maintaining contractile function and metabolic homeostasis in the hypertensive heart, and STAT3 deficiency promotes a switch toward glucose utilization.

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Section: Discussionmentioning

confidence: 89%

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

et al. 2016

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“…Lactate can be picked up from cells by MCT, possibly along with extracellular transport from H + . Then be taken and used as fuel by adjacent skeletal muscles, as well as the heart, brain, liver and kidneys so that the blood lactic acid level can be decreased [12].…”

Section: Resultsmentioning

confidence: 99%

Comparison of Far Infrared Radiation and Warm Water Immersion on Recovery After Submaximal Physical Activity

Wahjuni¹,

Kaharina²,

Yulfadinata³

et al. 2019

Proceedings of the 5th International Conference on Physical Education, Sport, and Health (ACPES 2019)

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Recovery is an attempt to make the body recover after physical training. Passive recovery includes Far Infrared Radiation (FIR) and Warm Water Immersion (WWI), but the two recoveries are not well known. The aims of this study were to test the the efficacy of FIR, WWI, and Passive (PAS) modalities in decreasing blood lactic acid levels (BLAL) as an indirect marker of muscle fatigue after submaximal intensity physical activity. This is a randomized pretest-posttest control group research. The subject were 21 male students at the UNESA Sports Science Faculty aged 18-23 years. They were assigned three different recovery modalities (FIR, WWI, PAS) in a random order. Subjects were treated with submaximal physical activity (85% maximal heart rate) with ergocycle. BLAL was assessed immediately after physical activity (pre), and after 15 minutes the tested (post). There was a significant decrease in BLAL from the three groups after recovery. The results of different tests (p <0.05) showed a significant difference between ∆FIR and ∆PAS (p=0.006), no differences between ∆WWI and ∆PAS (p=0,082), no differences between ∆FIR and ∆WWI (p=0,692). It can be concluded that the reduction in BLAL was greater in the FIR group than in the WWI and PAS groups.

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“…In this work, CL and HR have been proposed as fatigue parameters. The lactate is a highly sensitive biomarker that provides accurate information about anaerobic metabolism [24,25], easy to obtain, highly validated at the level of sports physiology [26], and others clinical contexts [27]. A subject with a CL level above 4 mmol/L -lacticaemia-after 20 minutes of rest implies that she/he continues with a high metabolic demand [28].…”

Section: Discussionmentioning

confidence: 99%

Fatigue among health care workers during emergency interventions using biological personal protective equipment: an observational simulation study

Martin-Rodríguez

Sanz-García

López-Izquierdo

et al. 2020

Preprint

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Background : Biohazard incidents are ordinary situations usually managed by health systems with the mandatory priority of preventing the spread of the pathogen. Health care workers in charge of dealing with these situations must be equipped with personal protective equipment (PPE) for her/his own security. The main objective of this study was developing a risk model to predict whether health care workers will tolerate wearing PPE, III category, 4B / 5B / 6B type, against biological risks during a 30 minutes intervention. Methods : A preliminary, prospective, simulation study, without intervention was conducted at the Advanced Simulation Center at the Medicine Faculty of Valladolid University (Spain) from April 3rd to 28th, 2017. Students and professional's health care were equipped with a PPE and performed a 30 minutes-long biohazard simulation. Anthropometric, physiological, analytical variables, and anxiety levels were measured pre- and post-simulation. A scoring model was constructed by using the estimate regression coefficients of the significant variables obtained from a multivariate model of the logistic regression for the outcome variable. Results : 96 volunteers with median age of 26 years (25th-75th percentile: 22-41 years) of which 56 (58.3%) were women enter into the test. Half of the sample presented metabolic fatigue after 20 minutes of finishing the simulation. The predictive model included female sex, height, both muscle and bone mass and moderate level of physical activity. The validity of the main model using all the variables presented an area under the curve (AUC) of 0.86 (95%CI: 0.786-0.935), and the validity of the model presented an AUC of 0.725 (95%CI: 0.559-0.89). Conclusions : Decision-making in biohazard incidents is a challenge for emergency team leaders. An a priori knowledge of physiological tolerance of wearing a PPE of the health care workers could improve their performance. The model presented here could help in the assessment of the worker response under biohazard conditions.

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Lactate: Friend or Foe

Cited by 67 publications

References 41 publications

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Comparison of Far Infrared Radiation and Warm Water Immersion on Recovery After Submaximal Physical Activity

Fatigue among health care workers during emergency interventions using biological personal protective equipment: an observational simulation study

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