Lactate: Early predictor of morbidity and mortality in patients with severe burns

Kamolz, Lars‐Peter; Andel, H.; Schramm, Wolfgang; Meissl, G.; Herndon, David N.; Frey, Maria Klara

doi:10.1016/j.burns.2005.06.019

Cited by 82 publications

(45 citation statements)

References 26 publications

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“…Serum lactate trends provide greater information regarding the homeostatic status (53,54). Determinations of BD do not demonstrate the same predictive power; the effect of specific correction of the BD during fluid resuscitation is unknown (13,50,52). There are insufficient data to make recommendations on the use of BD or lactate as resuscitation guidelines during burn resuscitation or as independent predictors of outcome in patients with large burns (5,32,51,55).…”

Section: First-line Monitoringmentioning

confidence: 95%

Critical care of the burn patient: The first 48 hours

Latenser

2009

Critical Care Medicine

185

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The critically burned patient differs from other critically ill patients in many ways, the most important being the necessity of a team approach to patient care. The burn patient is best cared for in a dedicated burn center where resuscitation and monitoring concentrate on the pathophysiology of burns, inhalation injury, and edema formation. Early operative intervention and wound closure, metabolic interventions, early enteral nutrition, and intensive glucose control have led to continued improvements in outcome. Prevention of complications such as hypothermia and compartment syndromes is part of burn critical care. The myriad areas where standards and guidelines are currently determined only by expert opinion will become driven by level 1 data only by continued research into the critical care of the burn patient.

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Section: First-line Monitoringmentioning

confidence: 95%

Critical care of the burn patient: The first 48 hours

Latenser

2009

Critical Care Medicine

185

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“…Serum lactate levels are one of these initial laboratory findings. Early and effective clearance of serum lactate (i.e., lower levels) are associated with lower mortality in patients with many critical illnesses, including sepsis and severe trauma [13][14][15][16][17][18] . For cardiac arrest survivors, the relationships between clearance of serum lactate and neurological and survival outcomes have been studied [19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Correlation between initial serum levels of lactate after return of spontaneous circulation and survival and neurological outcomes in patients who undergo therapeutic hypothermia after cardiac arrest

et al. 2015

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“…8 -10 Additional research suggested a predictive relationship between elevation of initial serum lactate value and death among burn patients. 11,12 The goal of this study was to examine the relationship between values of serum lactate and base deficit obtained during the first 48 hours post-admission and subsequent mortality among burn patients. Secondary outcomes included development of acute respiratory distress syndrome (ARDS), development of sepsis, development of acute renal failure, number of ventilator days, and hospital length of stay (LOS).…”

mentioning

confidence: 99%

The Relationship of Serum Lactate and Base Deficit in Burn Patients to Mortality

Cochran

Edelman

Saffle

et al. 2007

Journal of Burn Care & Research

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Serum lactate and base deficit in trauma patients have been shown to correlate with mortality. This study examines the relationship of these parameters to mortality among burn patients. We evaluated patients with >or=20% TBSA burn injury who had a serum lactate or base deficit recorded during the initial 48 hours of admission over a 5-year period. The primary study outcome was mortality. The mean (+/-SD) age of study patients (N = 128) was 35.2 +/- 21.1 years, the mean burn size was 41.7 +/- 17.9% TBSA, and the mortality rate was 17.1%. Mean serum lactate values of patients who died were significantly higher than those of survivors at admission and at 12, 18, and 24 hours after admission. The highest serum lactate value in the first 48 hours after admission was higher for nonsurvivors than survivors. Mean base deficit at admission and 6 hours after admission was significantly lower in patients who died than in survivors; in addition, the worst base deficit during the first 48 hours of care was significantly lower in patients who died than in those who survived. Early serum lactate and base deficit values are often worse for burn patients who die than for survivors. Elevation of serum lactate values during the first 48 hours after a burn is an independent risk factor for death, but no threshold value for serum lactate is demonstrable. Resuscitation should not be withheld from burn patients on the basis of any lactate or base deficit value.

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Lactate: Early predictor of morbidity and mortality in patients with severe burns

Cited by 82 publications

References 26 publications

Critical care of the burn patient: The first 48 hours

Critical care of the burn patient: The first 48 hours

Correlation between initial serum levels of lactate after return of spontaneous circulation and survival and neurological outcomes in patients who undergo therapeutic hypothermia after cardiac arrest

The Relationship of Serum Lactate and Base Deficit in Burn Patients to Mortality

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