Lactate Dehydrogenase in Bronchoalveolar Lavage Fluid of Patients with Active Pulmonary Tuberculosis

Emad, Ali; Rezaian, Gholam Reza

doi:10.1159/000029335

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…The measurement of different intracellular enzymes in the BAL supernatant could indicate injury to the interstitial tissue and contribute to the etiological diagnosis [11][12][13]. LDH is an intracellular enzyme found in different tissues of the body, but its presence is greater in the heart, liver, kidney, muscle, red blood cells, leukocytes, brain and lungs.…”

Section: Discussionmentioning

confidence: 99%

Bronchoalveolar Wash: Proposal of a Cutting Point for Lactate Dehydrogenase in the Differential Diagnosis of Pulmonary Diseases

Angeleri¹,

Rocher²,

Ciordía³

et al. 2017

Clin Infect Immun

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Background: The analysis of bronchoalveolar lavage (BAL) is of great clinical utility in the diagnosis of pulmonary diseases (PDs). The cytological study (total and differential cell count) performed routinely in these samples, has a high orientative power and is diagnostic in some cases. The study of soluble substances has provided little information. This study aimed to determine the cut-off point of lactate dehydrogenase (LDH) activity in the diagnosis of different lung diseases.

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Section: Discussionmentioning

confidence: 99%

Bronchoalveolar Wash: Proposal of a Cutting Point for Lactate Dehydrogenase in the Differential Diagnosis of Pulmonary Diseases

Angeleri¹,

Rocher²,

Ciordía³

et al. 2017

Clin Infect Immun

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“…This observation has not been widely reported and in the available studies, specific isoenzymes of LDH have often not been analysed. Raised LDH values have been observed in immunologically mediated lung injury, lung infections, obstructive airways disease, parenchymal lung diseases as well as pulmonary vascular disease (2–13, 22, 23). In respiratory disease, isoenzymes 3, 4 and 5 are increased as compared to the normal serum pattern.…”

Section: Discussionmentioning

confidence: 99%

“…These include obstructive airways disease such as bronchial asthma and chronic obstructive pulmonary disease (COPD) (2–4). Raised LDH levels have been noted in respiratory infections such as pulmonary tuberculosis, bronchopneumonia, Pneumocystis jiroveci pneumonia, avian influenza and the corona virus‐related severe acute respiratory syndrome (5–10). Raised levels of LDH are also noted in several of the interstitial lung diseases including idiopathic pulmonary fibrosis, extrinsic allergic alveolitis, desquamative interstitial pneumonia and cryptogenic organising pneumonia (5, 11–13).…”

Section: Introductionmentioning

confidence: 99%

Serum LDH in chronic cough: a potential marker of airway inflammation

Faruqi

Wilmot

Wright

et al. 2011

Clinical Respiratory J

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Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH-1 to LDH-5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increased in patients with chronic cough. We wanted to confirm this finding, study the reproducibility and determine the origin of the LDH. Methods: Patients prospectively seen at the Hull Cough Clinic had total and specific LDH isoenzyme levels in serum determined. A subgroup of patients also had a serum creatine phosphokinase (CK) measured. Patients completed cough symptom scores and the Hull Airway Reflux Questionnaire (HARQ). Spirometry was performed. Results: Eighty-three patients were included. Forty-two percent had LDH values above the reference range and 78% had LDH values in the fourth quartile of the reference range or above. This increase in LDH was predominantly because of a rise in isoenzymes 4 and 5. The increase in LDH was found to be reproducible at 8 weeks. Ten percent had CK values above the normal range. There was no correlation observed between LDH values and the cough scores, HARQ scores or lung function. Conclusion: Serum LDH levels are elevated in a substantial proportion of patients with chronic cough. This rise is likely to be due to airway inflammation known to be associated with chronic cough.Please cite this paper as: Faruqi S, Wilmot R, Wright C and Morice AH. Serum LDH in chronic cough: a potential marker of airway inflammation. Clin Respir J 2012; 6: 81-87.

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“…The symptoms and findings of nonspecific pulmonary infections in cases of past tuberculosis mask the reactivation of tuberculosis, and make it difficult to diagnose tuberculosis. For that reason, different parameters have been studied as activity criteria [10,11,12]. …”

Section: Discussionmentioning

confidence: 99%

A New Parameter in the Detection of Tuberculosis Activity: Reactive Oxygen Metabolites

Ceylan

Gülsün²,

Gençer³

et al. 2005

Respiration

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Background and Objectives: In countries with a high frequency of tuberculosis, there are problems not only with active lung tuberculosis but also with past lung tuberculosis. Cases with sequel tuberculosis very frequently present with complaints like tuberculosis, and it is very hard to determine whether it is a sequel tuberculosis complication or reactivation of tuberculosis. In this study, we measured the serum reactive oxygen metabolite (ROM) levels of patients with active pulmonary tuberculosis and healthy controls, and investigated if these metabolites can be used as a criterion for differentiation between active pulmonary tuberculosis and sequel pulmonary tuberculosis. Methods: 40 patients with active tuberculosis, 35 patients with sequel pulmonary tuberculosis and 30 healthy control subjects with a similar age range and sex distribution were included in the study. Serum total ROM levels were detected in the patients and control group. Results: Mean serum ROM values were 994 ± 236, 551 ± 135 and 236 ± 59 U/l among active lung tuberculosis cases, sequel lung tuberculosis cases and the healthy control group, respectively. As a result of these findings, serum ROM levels of active lung tuberculosis cases and sequel lung tuberculosis cases were significantly higher than those of the control group (both p < 0.001). The serum ROM levels of active lung tuberculosis cases were also significantly higher than those of sequel lung tuberculosis cases (p < 0.001). Conclusions: In the light of our findings, it may be assumed that serum total ROM values can be used as an activity criterion in the differentiation of active lung tuberculosis and sequel lung tuberculosis.

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Lactate Dehydrogenase in Bronchoalveolar Lavage Fluid of Patients with Active Pulmonary Tuberculosis

Cited by 9 publications

References 12 publications

Bronchoalveolar Wash: Proposal of a Cutting Point for Lactate Dehydrogenase in the Differential Diagnosis of Pulmonary Diseases

Bronchoalveolar Wash: Proposal of a Cutting Point for Lactate Dehydrogenase in the Differential Diagnosis of Pulmonary Diseases

Serum LDH in chronic cough: a potential marker of airway inflammation

A New Parameter in the Detection of Tuberculosis Activity: Reactive Oxygen Metabolites

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