Lactate Dehydrogenase-Elevating Virus

Coutelier, Jean‐Paul; Brinton, Margo A.

doi:10.1016/b978-012369454-6/50036-4

Cited by 11 publications

(14 citation statements)

References 238 publications

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“…Gamma interferon (IFN-c) is deeply involved in the pathogenesis triggered indirectly by lactate dehydrogenase-elevating virus (LDV) in mice (Coutelier & Brinton, 2007;Musaji et al, 2004Musaji et al, , 2006. For example, we showed that LDV exacerbates the susceptibility of mice to shock induced by lipopolysaccharide (LPS).…”

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confidence: 92%

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Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus

Le-Thi-Phuong

Thirion

Coutelier

2007

Journal of General Virology

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Two distinct pathways of gamma interferon (IFN-γ) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN-γ production and requires the secretion of interleukin-12. This regulation of IFN-γ production by type I interferons may help to control indirect pathogenesis induced by this cytokine.

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confidence: 92%

“…A mere 2-fold increase in LDV titres, which was, however, significant (P50.0022 by non-parametric Mann-Whitney test), was observed in mice unresponsive to type I IFNs at 16 h post-infection, which corresponds to the highest level of viraemia (Coutelier & Brinton, 2007), as shown in Fig. 1(b).…”

mentioning

confidence: 99%

Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus

Le-Thi-Phuong

Thirion

Coutelier

2007

Journal of General Virology

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“…The characteristic feature of LDV infection is the increased activity of lactate dehydrogenase (LDH) and other plasma enzymes [8,226], which is due to the continuous destruction of permissive macrophages that are responsible for the clearance of LDH from the circulation. As a consequence, the activity of plasma LDH begins to rise by only 24 h after infection and peaks 3-4 days after infection at 5-10-fold normal levels, or can even be up to 20-fold in SJL/J mice.…”

Section: Rna Viruses Lactate Dehydrogenaseelevating Virusmentioning

confidence: 99%

“…Antigen-antibody complexes produced during infection circulate in the blood and are deposited in the glomeruli [226]. In contrast to other persistent virus infections (e.g.…”

Section: Rna Viruses Lactate Dehydrogenaseelevating Virusmentioning

confidence: 99%

“…In principle, serological methods such as IFA may be used for detecting LDV infection [230] but they are not of practical importance. Circulating virus-antibody complexes interfere with serological tests, and sufficient quantities of virus for serological tests are difficult to generate because LDV replicates only in specific subpopulations of primary cultures of murine macrophages and monocytes for one cell cycle [226]. However, it is meanwhile possible to use recombinant viral proteins of LDV as antigens [231] in ELISA and MFIA tests so that routine testing by serology is possible.…”

Section: Rna Viruses Lactate Dehydrogenaseelevating Virusmentioning

confidence: 99%

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