Lactate dehydrogenase activity in the myometrium, placenta, and blood of women with uterine inertia

Brilliantova, S. A.; Bogoyavlenskaya, N. V.; Kuznetsova, T V; Gurtovoi, B. L.

doi:10.1007/bf00787306

Cited by 3 publications

(3 citation statements)

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“…With congenital deficiency of lactate dehydrogenase (LDH, the enzyme required for lactate production), there is increased lactate and labour dystocia (Anai et al 2002). Furthermore, changes in plasma LDH levels and tissue activity associated with pregnancy and labour have been reported (Hawkins & Whyley, 1966;Brilliantova et al 1973;Makkonen et al 1980), and it has been suggested from plasma that changes in the profile of LDH isoforms may influence cervical dilatation (Neal et al 2013). Expression of LDH in human labouring myometrium has, however, not been quantified.…”

Section: Dysfunctional Labour and Physiological Studiesmentioning

confidence: 99%

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Insights from physiology into myometrial function and dysfunction

Wray

2015

Experimental Physiology

104

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After training in physiology at UCL, I took up a lectureship in Liverpool in 1990 and am now getting my long-service award! I enjoy exploring myometrial physiology and its interaction with metabolism, as well as thinking about how our science may be of relevance to women in labour. I also spend time mentoring female physiologists and serve as Director of Athena SWAN for my university. I am proud to have co-edited The Physiological Society's book celebrating the centenary of women being elected to the Society, and to have been a Joan Mott lecturer. New Findings r What is the topic of this review?I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. r What advances does it highlight?Physiological studies have recently shed light on the myometrium in twin pregnancies, but there have been no 'omic' approaches. In contrast, studies of preterm delivery using newer approaches are generating new research avenues, whereas traditional approaches have not flourished. Finally, I describe significant advances in understanding of 'slow-to-progress' labours, achieved using physiological and clinical approaches. Advances in molecular, genetic and 'omic' technologies are fuelling the thirst for better understanding of the uterus and application of this information to problems in pregnancy and labour. Progress has, however, been limited while we still have an incomplete understanding of some of the basic physiology of uterine smooth muscle (myometrium). In this review and opinion piece, I explore some of the fascinating findings from selected recent studies and see how these may provide new avenues for physiological and clinical research. It is also the case, however, that there is still limited mechanistic understanding about physiological and pathophysiological processes in the myometrium. This lack of understanding limits the usefulness of some findings from genomic and allied studies. By focusing on some key recent findings and relating these to two important clinical problems in childbirth that involve myometrial activity, namely preterm delivery and difficult labours, the interplay between our physiological knowledge and the information provided by newer technologies is explored. My opinion is that physiology has provided much more new mechanistic insight into difficult births and that the newer

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Section: Dysfunctional Labour and Physiological Studiesmentioning

confidence: 99%

“…Furthermore, changes in plasma LDH levels and tissue activity associated with pregnancy and labour have been reported (Hawkins & Whyley, ; Brilliantova et al . ; Makkonen et al . ), and it has been suggested from plasma that changes in the profile of LDH isoforms may influence cervical dilatation (Neal et al .…”

Section: Introductionmentioning

confidence: 99%

Insights from physiology into myometrial function and dysfunction

Wray

2015

Experimental Physiology

104

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“…L D H isoenzyme 2 was decreased in dys-functional labor in this investigation, which agrees with the study of Brilliantova ef al. (3), w h o show a decrease of heart type (H-type) LDH insoenzymes in dysfunctional labor.…”

Section: Arta Obsret Gynecolmentioning

confidence: 99%

Serum Lactic Acid Dehydrogenase and Isoenzymes During Pregnancy and Labor

Makkonen¹,

Penttilä²,

Castrén³

1980

Acta Obstet Gynecol Scand

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Total serum lactic acid dehydrogenase activity (LDH) and the levels of LDH isoenzymes were investigated in 14 women during early pregnancy (8--16th week), in 28 women during late pregnancy (29--37th week), in 73 at term (38--42nd week) and in 27 during labor (38--42nd week). LDH activity was found to be elevated in severe pre-eclampsia and in chronic hypertensive women during pregnancy as well as during normal and dysfunctional labor. No change was established in total serum LDH during normal pregnancy. LDH 1 was increased during late pregnancy and at term. In severe pre-eclampsia and during normal labor it was decreased. LDH 2 was also decreased in severe pre-eclampsia and during dysfunctional labor. LDH 3 was decreased during late pregnancy but increased in severe pre-eclampsia. No change was observed in LDH 4 during pregnancy, or in labor. LDH 5 was increased in normal and dysfunctional labor.

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Myometrial Energy Metabolism During Pregnancy and Normal and Dysfunctional Labor

Makkonen¹

1977

Acta Obstet Gynecol Scand

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Lactate dehydrogenase activity in the myometrium, placenta, and blood of women with uterine inertia

Cited by 3 publications

References 1 publication

Insights from physiology into myometrial function and dysfunction

Insights from physiology into myometrial function and dysfunction

Serum Lactic Acid Dehydrogenase and Isoenzymes During Pregnancy and Labor

Myometrial Energy Metabolism During Pregnancy and Normal and Dysfunctional Labor

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