Lactate biosensing: The emerging point-of-care and personal health monitoring

Alam, Fahmida; RoyChoudhury, Sohini; Umasankar, Yogeswaran; Forouzanfar, Shahrzad; Akter, Naznin; Pala, Nezih

doi:10.1016/j.bios.2018.06.054

Cited by 133 publications

(98 citation statements)

References 100 publications

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“…To simplify lactate analysis, enzyme is the most effective and easy to use form of natural catalyst. So, lactate sensors based on enzymes such as biocatalysts can be employed 10 . For example, lactate oxidase (LOx), a representative enzyme that degrades lactate, produces pyruvate and hydrogen peroxide (H 2 O 2 ), 10 and the produced H 2 O 2 can decompose metal nanoparticles, including those composed of MnO 2, 11 ZnO 2, 12 and gold, 13 and modified metal materials can be used as lactate sensors that operate by measuring decomposition.…”

Section: Introductionmentioning

confidence: 99%

A Dual‐Functional Lactate Sensor Based on Silver Nanoparticle‐coated Carbon Dots

Park

Min

et al. 2021

Bulletin Korean Chem Soc

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Herein, a silver nanoparticle-coated carbon dots (Ag-CDs) was fabricated to detect lactate using colorimetric and fluorometric methods. When the Ag-CDs were decomposed by H 2 O 2 produced from the lactate oxidase (LOx) catalytic reaction, the color of the Ag-CDs solution changed from yellowish to transparent, and the fluorescence of the quenched CDs was simultaneously recovered. Silver nanoparticles (Ag NPs) decomposition was confirmed by X-ray photoelectron spectroscopy, revealing an increase in Ag N bond peaks due to ionization of Ag NPs. The Ag-CDs sensor could recognize lactate specifically, even in the presence of numerous potentially interfering biomarkers. The fabricated sensor displayed good sensitivity and selectivity, with a low detection limit of 0.6 μM and 10 μM for H 2 O 2 and lactate sensing, respectively. Finally, the Ag-CDs sensor could be applied to determination of lactate to intracellular imaging in 4T1 cells using confocal microscopy.

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Section: Introductionmentioning

confidence: 99%

A Dual‐Functional Lactate Sensor Based on Silver Nanoparticle‐coated Carbon Dots

Park

Min

et al. 2021

Bulletin Korean Chem Soc

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“…For all these reasons, lactate monitoring is important and several detection systems have been developed [13][14][15] . Most of them involve enzymatic reactions of lactate oxidase and lactate dehydrogenase coupled to amperometric detection 16 or electrochemical biohybrid oxygen sensor based on natural bacteria metabolism 17 .…”

Section: Main Textmentioning

confidence: 99%

An engineered lactate responding promoter system operating in glucose-rich and anaerobic environments

Zúñiga

Chang

Fristot

et al. 2021

Preprint

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Bacteria equipped with genetically-encoded lactate biosensors would support several applications in biopharmaceutical production, diagnosis, or therapeutics. However, many applications involve glucose-rich and anaerobic environments, in which current whole-cell lactate biosensors have low performance. Here we engineered a synthetic lactate biosensor system by repurposing the natural LldPRD promoter regulated by the LldR transcriptional regulator. We removed glucose catabolite repression by designing a hybrid promoter, containing LldR operators and tuned both regulator and reporter gene expression to optimize biosensor signal-to-noise ratio. The resulting lactate biosensor, termed ALPaGA (ALactate Promoter Operating in Glucose and Anaerobia) can operate in glucose rich, aerobic and anaerobic conditions. Our work provides a versatile lactate biosensing platform suitable for many environmental conditions.

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“…In addition, the diversity of biofuels has been constantly expanded given the abundant biochemicals in the living body. Lactate has been shown to be useful in various medical devices, and as shown in Figure f, the power density, ranging from 5 to 70 µW cm −2 , is generated by noninvasive epidermal biofuel cells, through the oxidation of lactate in perspiration (at the lactate oxidase functionalized anode) and reduction of oxygen at the Pt‐black‐modified carbon cathode. By using mitochondria as the catalyst, pyruvate acid, succinate acid, fatty acids, and amino acids have also been shown to have potential applications in biofuel cells at the subcellular level.…”

Section: Power Harvesting Devices Utilize Sources From the Human Bodymentioning

confidence: 99%

Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics

Huang

Wang

et al. 2019

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Implantable bioelectronics represent an emerging technology that can be integrated into the human body for diagnostic and therapeutic functions. Power supply devices are an essential component of bioelectronics to ensure their robust performance. However, conventional power sources are usually bulky, rigid, and potentially contain hazardous constituent materials. The fact that biological organisms are soft, curvilinear, and have limited accommodation space poses new challenges for power supply systems to minimize the interface mismatch and still offer sufficient power to meet clinical‐grade applications. Here, recent advances in state‐of‐the‐art nonconventional power options for implantable electronics, specifically, miniaturized, flexible, or biodegradable power systems are reviewed. Material strategies and architectural design of a broad array of power devices are discussed, including energy storage systems (batteries and supercapacitors), power devices which harvest sources from the human body (biofuel cells, devices utilizing biopotentials, piezoelectric harvesters, triboelectric devices, and thermoelectric devices), and energy transfer devices which utilize sources in the surrounding environment (ultrasonic energy harvesters, inductive coupling/radiofrequency energy harvesters, and photovoltaic devices). Finally, future challenges and perspectives are given.

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Lactate biosensing: The emerging point-of-care and personal health monitoring

Cited by 133 publications

References 100 publications

A Dual‐Functional Lactate Sensor Based on Silver Nanoparticle‐coated Carbon Dots

A Dual‐Functional Lactate Sensor Based on Silver Nanoparticle‐coated Carbon Dots

An engineered lactate responding promoter system operating in glucose-rich and anaerobic environments

Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics

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