Lactate as a Predictor in Severe Pneumonia

Ose, Darta; Berzins, A.; Grigorovica, Krista; Klucniks, A.; Sabeļņikovs, Oļegs

doi:10.1515/chilat-2016-0006

Cited by 2 publications

(3 citation statements)

References 35 publications

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“…Likewise, in our study, similar results were obtained with previous publications, and also hemoglobin and hematocrit were lower, especially in patients who did not survive for a month. Furthermore, lactate levels of the non-survivors were signi cantly higher than the survivors, which is reportedly a predictor of severe pneumonia 20 .…”

Section: Discussionmentioning

confidence: 94%

“…In addition to symptoms such as dyspnea, increased LDH, D-dimer, PCT, ferritin, and leukocyte counts, and decreased lymphocyte counts have been speci ed as laboratory parameters that can be used to predict mortality in COVID-19 patients [18][19][20] . Moreover, hemoglobin (HGB) and hematocrit (HCT) values are also critical for these patients.…”

Section: Discussionmentioning

confidence: 99%

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Survival patterns of COVID-19 pneumonia patients with false-negative PCR results transferred to the intensive care unit from the emergency department

Kodik

2021

Preprint

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ObjectiveThis study aimed to analyze factors associated with patient mortality in COVID-19 patients hospitalized in the intensive care unit (ICU) and provide data to help prioritize the most critical patients.DesignRetrospective cohort studySetting and participantsData for 289 patients were analyzed by the XXX hospital’s IT department.MethodsA clinical retrospective cohort study was conducted in a tertiary hospital. Patients (n=289) with negative reverse transcription-polymerase chain reaction (RT-PCR) and positive chest computed tomography (CT) scan indicating COVID-19 were included in the research. Demographics, clinical characteristics, treatment modalities, and length of hospital stay were analyzed in relation to 30-day survival outcomes.ResultsThe mean age of the patients was 69.04±15.10 years (range 19-100), and 41.2% (n=119) were female. The mortality rate was 48.1% (n=139). There were statistically significant differences in laboratory findings, such as hemoglobin (p=0.021), lymphocyte counts (p=0.046), d-dimer (p=0.009), and lactate (<0.001) regarding one-month survival. Additionally, those hospitalized for more than 5 days had higher one-month survival rates (hazard ratio (HR)= 0.003, CI= 10.264-155.972). Moreover, intubated patients had a higher mortality risk during this period (HR=4.15, CI=1.53-11.20).Conclusions and implicationsThe first five days of patients hospitalized in intensive care units due to COVID-19 pneumonia are critical. Besides, the need for intubation was another factor independently affecting survival. Clinicians should be alerted about the significance of these factors.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Survival patterns of COVID-19 pneumonia patients with false-negative PCR results transferred to the intensive care unit from the emergency department

Kodik

2021

Preprint

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“…Several studies showed that lactate measurement had clinical utility in initial evaluation and management of pneumonia. [10][11][12][13][14][15][16][17] Several point-of-care devices are available for lactate measurement, which only need microliters of blood. Compared to arterial sampling, capillary sampling is easier to perform, less painful, cheaper, confer faster results, and able to decrease the chance of needle stick injury to health workers.…”

Section: Introductionmentioning

confidence: 99%

Capillary Lactate Level in Non-Severe and Severe CommunityAcquired Pneumonia Patients

Resti Yudhawati,

Kowiy Akbar

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Community-acquired pneumonia is an inflammatory disease of the lung caused by microorganisms acquired from a non-hospital environment. The pneumonia severity index and ATS/IDSA severity criteria are widely used to predict the severity of CAP. Lactate is a biomarker that can be measured by point-of-care devices that provide results in a short of time. This study aimed to determine the difference in capillary lactate level between non-severe and severe pneumonia to provide an additional method to quickly stratify pneumonia severity and treat it accordingly. Methods: This cross-sectional study was performed in the emergency room of a regional research hospital. The pneumonia diagnosis was determined by the symptoms, physical examination and radiological findings. Capillary lactate level was measured with Accutrend Plus lactate point-of care device. Severity stratification was done according to ATS/IDSA criteria. The mean of lactate level in all subjects was 3.40±1.52, in nonsevere pneumonia subgroup was 2.25±0.94, and 4.56±1.01 in severe pneumonia subgroup. Lactate is significantly higher in severe pneumonia subgroup. The cut-off point of lactate level for severity group was 3.2 mmol/L (95.5% sensitivity, 86.4% specificity). Conclusion:The early prediction of CAP severity is essential to determine the need for admission in the intensive care unit and close follow up. The lactate level can be used for immediate severity stratification in emergency departments.

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Lactate as a Predictor in Severe Pneumonia

Cited by 2 publications

References 35 publications

Survival patterns of COVID-19 pneumonia patients with false-negative PCR results transferred to the intensive care unit from the emergency department

Survival patterns of COVID-19 pneumonia patients with false-negative PCR results transferred to the intensive care unit from the emergency department

Capillary Lactate Level in Non-Severe and Severe CommunityAcquired Pneumonia Patients

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