Lacrimal Gland Volume Changes in Unilateral Primary Acquired Nasolacrimal Obstruction

Yazıcı, Alper; Bülbül, Erdoğan; Yazıcı, Haşmet; Sarı, Esin Söğütlü; Tıskaoğlu, Nesime Setge; Yanık, Bahar; Ermiş, Sıtkı Samet

doi:10.1167/iovs.15-16873

Cited by 13 publications

(11 citation statements)

References 21 publications

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“…This increase supports the observed tear secretion phenotype in SCD-1 KO mice (Fig. 2A–C ) 15 . In SCD-1 KO mice, the expression levels of lipid metabolism genes such as FASN, LDLR and UCP-1 were determined by qRT-PCR analysis.…”

Section: Resultssupporting

confidence: 89%

Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency

Inaba

Tanaka

Tamaki

et al. 2018

Sci Rep

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The stearoyl-CoA desaturase (SCD) family of enzymes catalyzes monounsaturated fatty acid synthesis by inserting a cis double bond at the Δ9 position of saturated fatty acids. Disruption of these enzymes has been reported to induce a severe dry skin phenotype. Since lipid abnormalities in the meibomian glands have been associated with dry eye, we analyzed selected eye tissues contributing to tear volume and composition in genetically SCD-1-deficient mice (SCD-1 KO), including the lacrimal glands and conjunctiva. Previous histopathological analysis had revealed atrophy and loss of meibomian glands; taken together with the increased goblet cell and MUC5AC expression in the conjunctiva reported here, these findings suggest that the tear volume and mucin levels secreted are enhanced in the absence of lipid secretion as a compensatory mechanism. The expression of lipid metabolism genes in lacrimal glands was decreased in SCD1 KO mice. Thus, these results provide new pathophysiological mechanisms to pursue with regard to meibomian gland dysfunction. In addition, lack of SCD-1 causes a compensatory increase in the tear volume and mucin levels associated with changes in expression of lipid metabolism genes. These results may be useful as a new concept for dry eye treatment strategies.

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Section: Resultssupporting

confidence: 89%

Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency

Inaba

Tanaka

Tamaki

et al. 2018

Sci Rep

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“…In the observation of the fellow eye, the Korb score of the fellow eye was signi cantly lower after surgery than before (P = 0.004), which can be explained by the ''cross-sensory stimulation''viewpoint [10] , where lacrimal obstruction was resolved in the PANDO eye, leading to increased surface moisture on the fellow eye.The differences in other indicators between pre-and postoperative measurements were not statistically signi cant.…”

Section: Discussionmentioning

confidence: 91%

“…A study reported that thirty patients (27.3%) were diagnosed with dry eye syndrome (DES) after EDCR, while 80 patients(72.7%)were normal [11] . Lacrimal gland volumes were bilaterally smaller in unilateral PANDO patients [10] . In cases of PANDO,dysregulation of certain cytokines were observed, including Matrix metalloproteinase 9 (MMP 9), Interleukin 6 (IL-6), c-reactive protein (CRP), etc [12] .Tear-Film Osmolarity of PANDO eye was increased after successful endoscopic dacryocystorhinostomy (EDCR)surgery [13] .…”

Section: Introductionmentioning

confidence: 83%

“…Hormones affect both the ocular surface and Lacrimal duct system [34,35,36,37,38,39] ; the ocular surface and lacrimal system are in a similar microenvironment [39,40] . The''cross-sensory stimulation''viewpoint [10] and the concept of the lacrimal gland functional unit (LFU) [14] both stem from an understanding of the unity of the ocular surface and Lacrimal duct system.…”

Section: Discussionmentioning

confidence: 99%

“…When this homeostasis is disrupted or the system fails to compensate, the resulting tear lm instability leads to a vicious cycle of tear hyperosmolarity and dry eye disease [6,7] . Some studies have shown that diseases that affect the stability of a single tear lm can lead to changes in tears in both eyes [8,9,10] . PANDO and ocular surface diseases such as dry eye have similar etiology and epidemiological characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Ocular surface parameters changes following endoscopic Dacryocystorhinostomy in Primary Acquired Nasolacrimal Duct Obstruction

Zhang,

Li,

Zhang

et al. 2023

Preprint

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Purpose: To evaluate Ocular surface parameters in patients with epiphora caused byprimary acquired nasolacrimal obstruction(PANDO), before and after endoscopic dacryocystorhinostomy (EDCR) and to compare with fellow eyes. Materials and Methods: One hundred and twenty-nine patients who underwent successful dacryocystorhinostomy surgery were included in the study.The Sjögren’s International Collaborative Clinical Alliance (SICCA) ocular staining score (OSS), tear break-up time (TBUT), Schirmer tear test (with and without anesthesia), and Lid wiper staining score of PANDO eyes and fellow eyes were measured preoperatively and postoperatively at 1 month. Results: Preoperatively,the SICCA OSS score of the PANDO eye was significantly lower than that of the fellow eye (P<0.001),Schirmer test I (without anesthesia) of PANDO eye was significantly higher than that of fellow eye(P=0.024).The differences observed between PANDO eyes and fellow eyes in all other parameters were not significant (p>0 .05).After surgery, the differences between the PANDO eye and fellow eye gradually disappeared(p>0 .05). In PANDO eyes,when comparing preoperative values with postoperative values，SICCA OSS values showed a statistically significant increase（P<0.001），Schirmer tear test (without and with anesthesia)(P=0,P=0.046)、and Lid wiper staining Korb score(P=0.004)showed a statistically significant decrease. In fellow eyes,when comparing preoperative values with postoperative 1-monthvalues, the Korb score of the fellow eye was significantly lower after surgery than before (P=0.004),all other parameters showed no significant changes. Conclusions: Obstruction of Nasolacrimal Duct results in the decrease of tear clearance and the increase of wetness of ocular surface.After successful endoscopic dacryocystorhinostomy （EDCR）surgery,the moisturization of PANDO eyes were reduced,the differences observed between PANDO eyes and fellow eyes in all parameters were disappeared.

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Reduced tear break-up time in the fellow eye of patients with unilateral primary acquired nasolacrimal duct obstruction

Tıskaoğlu

Yazıcı

2022

Int Ophthalmol

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Lacrimal Gland Volume Changes in Unilateral Primary Acquired Nasolacrimal Obstruction

Abstract: Compared to the control group, lacrimal gland volumes were bilaterally smaller in unilateral PANDO patients. Schirmer scores were statistically lower in the contralateral non-PANDO side compared to the controls.

Cited by 13 publications

References 21 publications

Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency

Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency

Ocular surface parameters changes following endoscopic Dacryocystorhinostomy in Primary Acquired Nasolacrimal Duct Obstruction

Reduced tear break-up time in the fellow eye of patients with unilateral primary acquired nasolacrimal duct obstruction

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