Lacrimal canalicular stenosis associated with systemic 5‐fluorouracil therapy

Abstract

ABSTRACT.Purpose: Ocular side effects of systemic 5-fluorouracil therapy include excessive lacrimation which often resolves on cessation of therapy. Permanent stenosis of lacrimal puncta and canaliculi is rare. This report highlights this uncommon complication of 5-fluorouracil therapy. Methods: Report of two cases and review of literature. Results: Severe stenosis of puncta and canaliculi may be associated with prolonged systemic 5-fluorouracil therapy. Conclusion: It is important for both the oncologist and ophthalmologist to be aware of the potential ocular toxicity of 5-fluorouracil. Surgical management to relieve the epiphora is often challenging, and early intervention may be beneficial.

Predictive factors for ocular complications caused by anticancer drug S-1

“…Predictive factors for ocular complications caused by anticancer drug S-1 69 subepithelial nerves, and dysplasia and fibrosis of conjunctival cells [17][18][19][20][21][22]. In this study, patients in the positive group, showing side-effects of S-1 chemotherapy, were significantly older than those in the negative group, who developed not sideeffects.…”

Dacryoendoscopic observation and incidence of canalicular obstruction/stenosis associated with S-1, an oral anticancer drug

“…Hassan et al [7] report patients with canalicular fibrosis who received 5-FU treatment for three times the duration and at 2.6 times the total dose as that for patients without fibrosis. Prasad et al [20] report that a Common canalicular obstruction in case 2. b View of the slit-like nasolacrimal duct (arrowheads) in case 2. The slitlike nasolacrimal duct shows no stenosis.…”

Prognostic factors for graft success in tympanoplasty with mastoidectomy

“…[1] In the literature, nasolacrimal duct involvement has been reported secondary to radiotherapy, foreign substance, specific inflammatory diseases as sarcoidosis, or Wegener's granulomatosis, specific infections as lepra, tuberculosis and rhinosporidiosis, primary neoplasms, herpes simplex disease, secondary to extrinsic tumors and acquired LDO secondary to very diverse etiologies as 5-fluorouracil treatment have been reported. [2][3][4][5] However, in two-thirds of the patients, the etiology of the constriction could not be found and these cases were considered to be idiopathic. [6] Familial tendency, anatomical variations and recurrent infections of the nasolacrimal duct are considered as predisposing factors.…”