Lack ofBCL10 mutations in multiple myeloma and plasma cell leukemia

Shih, Lee‐Yung; Fu, Jen-Fen; Shurtleff, Sheila; Morris, Stephan W.; Downing, James R.

doi:10.1002/1098-2264(2001)9999:9999<::aid-gcc1106>3.0.co;2-f

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…Age and male gender have also been associated with an increased risk of multiple myeloma. Genetic polymorphisms explain the risk of multiple myeloma in different studies and offspring of parents diagnosed with multiple myeloma have a higher relative risk [10][11][12][13][14][15][16]. Body mass or nutritional status may play a role in the development of multiple myeloma, while high dietary intakes of green vegetables and fish have been associated with a lower risk of the disease [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Impact of Environmental Factors on the Risk of Multiple Myeloma, a Case-Control Study in Myanmar

2023

J Community Med Public Health

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Background: Environmental factors, including exposure to chemicals and certain pathogens, may increase the risk of developing Multiple Myeloma (MM), as indicated by studies conducted primarily in industrialized countries. On the other hand, some epidemiological and experimental data also support the hypothesis that exposure to infections may enhance cancer immunosurveillance, particularly against multiple myeloma. Aim: To improve our understanding of the association between environmental factors and the risk of multiple myeloma, particularly in developing countries, this research was conducted to ascertain, in a South-East Asian setting, if environmental factors can modulate the risk of developing multiple myeloma. Methodology: A hospital-based case-control study was conducted using simple questionnaires in two large public hospitals in Myanmar from July to September 2020, with 40 multiple myeloma cases and a double control population seeking care in the medical and surgical Units of the same hospitals. Results: Even if not significant, our results suggest an increased risk of developing multiple myeloma after exposure to chemicals used in farming, and a reduced risk for those with a history of infections such as tuberculosis, hepatitis, measles, or pneumonia. The reduction was significant for malaria at the country level. Conclusion: These results support the idea that certain infections can improve cancer immunosurveillance, although they still need to be confirmed in other series of patients.

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Section: Introductionmentioning

confidence: 99%

Impact of Environmental Factors on the Risk of Multiple Myeloma, a Case-Control Study in Myanmar

2023

J Community Med Public Health

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Multiple myeloma: A review of the epidemiologic literature

et al. 2007

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Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

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