Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice

Chien, Chen-Li; Lin, Meng-Syuan; Lai, Hsing‐Lin; Wu, Yu-Shuo; Chang, Ching-Pang; Chen, Huei-Mei; Chang, Chen; Su, Chin Cheng; Chern, Yijuang

doi:10.1016/j.expneurol.2013.05.015

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…The localization of AC6 in osteocyte cilia likely contributes to its role in loading-induced bone adaptation (Lee et al, 2014). Other functions of AC6 include the regulation of basal sympathetic nerve discharge or sympathetic tone within the brain stem (Chien et al, 2013) and regulation of cAMP-dependent pancreatic amylase and fluid secretion (Sabbatini et al, 2013). In humans, the ADCY6 S674 variant results in a hyperfunctional AC6 protein (Gros et al, 2007), but follow up studies are required.…”

mentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Dessauer¹,

Watts²,

Ostrom³

et al. 2017

Pharmacol Rev

164

198

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mentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Dessauer¹,

Watts²,

Ostrom³

et al. 2017

Pharmacol Rev

164

198

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“…Fetal and maternal HRV features in time and frequency domains were analyzed under two types of solutions: non-pharmacological (saline), and pharmacological. The later considers parasympathetic (cholinergic) blockades such as atropine ( Morris et al, 2007 ), and sympathetic (adrenergic) blockades such as propranolol ( Chien et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Investigating the effect of cholinergic and adrenergic blocking agents on maternal-fetal heart rates and their interactions in mice fetuses

et al. 2022

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This study examines the role of autonomic control of Maternal and Fetal Heart Rate Variability (MHRV and FHRV) and their heartbeats phase Coupling Prevalence (CPheartbeat) in mice. The subjects are divided into three groups: control with saline, cholinergic blockade with atropine, and β-adrenergic blockade with propranolol. Electrocardiogram signals of 27 anesthetized pregnant mice and 48 fetuses were measured for 20 min (drugs were administered after 10 min). For the coupling analysis, different maternal heartbeats were considered for one fetal beat. Results show that saline infusion did not produce any significant changes in MHRV and FHRV, as well as CPheartbeat. Atropine increased Maternal HR (MHR) and decreased MHRV significantly without any considerable effect on Fetal HR (FHR) and FHRV. Propranolol infusion did not produce any significant changes in MHR and MHRV, but significantly decreased FHR and increased FHRV. Moreover, atropine had led to a decrease in CPheartbeat when considering 2 and 3 maternal beats, and an increase for 4 beats; while propranolol resulted in a decrease for 2 heartbeats, but an increase for 4 and 5 beats. The proposed approach is useful for assessing the impact of maternal autonomic modulation activity on fetal distress and obstetric complications prevalent in pregnant mothers.

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“…AC6 is a calcium-inhibited AC that is widely expressed in many brain areas at moderate levels 3 . We previously demonstrated that AC6 negatively modulates neurite outgrowth in hippocampal neurons and controls sympathetic tone in the brainstem 4 5 . The function of AC6 in the brain remains largely uncharacterized.…”

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confidence: 99%

Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning

Chang

Lee²,

Hou³

et al. 2016

Sci Rep

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The calcium-sensitive type VI adenylyl cyclase (AC6) is a membrane-bound adenylyl cyclase (AC) that converts ATP to cAMP under stimulation. It is a calcium-inhibited AC and integrates negative inputs from Ca2+ and multiple other signals to regulate the intracellular cAMP level. In the present study, we demonstrate that AC6 functions upstream of CREB and negatively controls neuronal plasticity in the hippocampus. Genetic removal of AC6 leads to cyclase-independent and N-terminus of AC6 (AC6N)-dependent elevation of CREB expression, and enhances the expression of GluN2B-containing NMDA receptors in hippocampal neurons. Consequently, GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6−/− mice without altering the gross anatomy of the brain. Together, our results suggest that AC6 negatively regulates neuronal plasticity by modulating the levels of CREB and GluN2B in the hippocampus.

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Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice

Cited by 3 publications

References 28 publications

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Investigating the effect of cholinergic and adrenergic blocking agents on maternal-fetal heart rates and their interactions in mice fetuses

Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning

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