Lack of tumor necrosis factor alpha gene polymorphism ‐857c/t (rs1799724) association in Pakistani rheumatoid arthritis patients

Sadaf, Tayyaba; John, Peter; Bhatti, Attya; Jahangir, Sidrah; Kiani, Aysha Karim; Gill, Farah A.; Malik, Javed Mehmood

doi:10.1111/1756-185x.12857

Cited by 3 publications

(3 citation statements)

References 33 publications

(63 reference statements)

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“…It determined that the TNFA -857C/T SNP is not associated with the risk of developing RA. Few studies of the association of this SNP with RA have been published, but our data agree with those reported for a Pakistani population [17], though not with those from a Chinese Han sample. It is important to note that the allelic frequencies in the study of the Chinese Han population were not in the Hardy-Weinberg equilibrium [18].…”

Section: Discussionsupporting

confidence: 80%

The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population

Agraz‐Cibrián

León

Durán‐Avelar

et al. 2019

Journal of Immunology Research

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Rheumatoid arthritis (RA) is a chronic inflammatory disease whose association with SNPs has led to the identification of biomarkers in different populations. To determine the association of the -857C/T SNP of the TNFA gene with RA and clinical parameters, 233 RA patients and 237 healthy controls were included in this study. The -857C/T polymorphism was determined using the TaqMan® system and clinical features were also determined. We found that the -857C/T SNP was in Hardy-Weinberg equilibrium. Our results showed no association of the -857C/T SNP with RA; however, RA patients carrying the TT genotype showed lower anti-CCP levels than other groups. Therefore, the TT genotype could be a risk factor for developing anti-CCP-negative RA. Our results suggest that the T allele of the TNFA -857C/T SNP exerts an influence on anti-CCP levels and could be a candidate marker for anti-CCP-negative RA.

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Section: Discussionsupporting

confidence: 80%

The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population

Agraz‐Cibrián

León

Durán‐Avelar

et al. 2019

Journal of Immunology Research

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“…Despite conflicting data regarding rs17999724 and autoimmune diseases, the findings agree with meta-analyses of diseases such as ankylosing spondylitis [20], Crohn’s disease [21] and vitiligo [18] using additive, dominant, and allele models. In contrast, a lack of this association was documented for idiopathic nephrotic syndrome [30] and rheumatoid arthritis [31]. These contradictory results might be explained by differences in ethnic origin or disease presentation or in number of individuals studied.…”

Section: Discussionmentioning

confidence: 99%

Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis

Motawi

El-Maraghy

Sharaf

et al. 2019

Journal of Advanced Research

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“…Conversely, inconsistency among the different studies exists regarding TNF-α promoter polymorphisms’ association with RA outcome [14, 15]. There are limited data available concerning SNPs and RA disease susceptibility association in Pakistan [16, 17]. Still, there is a great need to explore the association studies of RA susceptible genes’ polymorphism not only in our study group but also in different ethnic groups due to conflicting results.…”

Section: Introductionmentioning

confidence: 96%

Lack of association of –863C/A (rs1800630) polymorphism of tumor necrosis factor-α gene with rheumatoid arthritis

Sadaf

John

Bhatti

et al. 2019

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IntroductionMultifunctional pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) has been implicated in a variety of inflammatory diseases including rheumatoid arthritis (RA). TNF-α polymorphisms are mostly located in its promoter region and play a significant role in disease susceptibility and severity. We therefore sought to investigate TNFA –863C/A (rs1800630) polymorphism association with RA activity in our Pakistani study group.Material and methodsA total of 268 human subjects were enrolled. Among them, 134 were RA patients and 134 were controls. In this study the physical parameters of RA patients were collected, and the disease activity was measured by DAS28. The genotypes were determined following the allele-specific PCR along with the pre-requisite internal amplification controls. Subsequently, data were analyzed statistically for any significant association including χ2/Fisher’s exact test using GraphPad prism 6 software.ResultsWe found that the TNF-α –863 C/A (rs1800630) variant was not differentially segregated between cases and controls in either genotype frequency, with χ2 of 2.771 and a p-value of 0.2502, or allele frequency, with χ2 of 2.741 and a p-value of 0.0978, with an odds ratio (95% CI) of 0.7490 (0.5317–1.055).ConclusionsThe lack of positive association of TNF-α –863(rs1800630) polymorphism in our study group implies that TNF-α –863 polymorphism is not a susceptible marker to RA and cannot serve as a genetic factor for screening RA patients in Pakistan. There might be other factors that may influence disease susceptibility. However, further investigations on additional larger and multi-regional population samples are required to determine the consequences of genetic variations for disease prognosis.

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Lack of tumor necrosis factor alpha gene polymorphism ‐857c/t (rs1799724) association in Pakistani rheumatoid arthritis patients

Cited by 3 publications

References 33 publications

The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population

The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population

Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis

Lack of association of –863C/A (rs1800630) polymorphism of tumor necrosis factor-α gene with rheumatoid arthritis

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