Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes

Lacerda, José Thalles Jocelino Gomes de; Gomes, Patrícia R. L.; Zanetti, Giovanna; Mezzalira, Nathana; Lima, Otoniel G. de; Assis, Leonardo Vinícius Monteiro de; Güler, Ali D.; Castrucci, Ana Maria de Lauro; Moraes, Maria Nathália

doi:10.3390/ijms23137014

Cited by 9 publications

(5 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AKT, a serine/threonine protein kinase, is a major downstream effector of PI3K [24]. Activated AKT promotes glycogen synthesis and glycolysis through a variety of downstream targets [25]. When the blood sugar level increases, insulin stimulates the activation and phosphorylation of PI3K and AKT, thereby regulating downstream GSK3β and GS, which are the main regulatory factors for glycogen synthesis [26].…”

Section: Discussionmentioning

confidence: 99%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

View full text Add to dashboard Cite

The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investigate the hypoglycemic mechanism of cinnamon powder (CP) from the perspective of regulating liver glucose metabolism. To achieve this, different doses of CP (200, 400, or 800 mg/kg body weight) were given to diabetic mice by gavage once per day for 8 weeks. These mice were compared with healthy controls, untreated diabetic mice, and diabetic mice treated with metformin (the main first-line drug for type 2 diabetes). CP treatment effectively reduced fasting blood glucose levels and food intake, improved glucose tolerance and fasting serum insulin levels, and decreased glycated serum protein levels in diabetic mice. Furthermore, treatment with CP increased liver glycogen content and reduced the level of the gluconeogenesis precursor pyruvate in the liver. Data obtained by qPCR and western blotting suggested that CP improved glucose metabolism disorders by regulating AMPKα/PGC1α-mediated hepatic gluconeogenesis and PI3K/AKT-mediated hepatic glycogen synthesis. CP exhibits good hypoglycemic effects by improving hepatic glycogen synthesis and controlling hepatic gluconeogenesis. Therefore, CP may be applied as a functional food to decrease blood glucose.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…These differential proteins may suggest a correlation between TRPV1 and liver metabolism and dysfunction. The downregulation of Transient Receptor Potential Vanilloid 1 (TRPV1) expression in liver cirrhosis tissue, caused by a variety of etiologies, has been observed [101]. This study demonstrates a significant decrease in TRPV1 expression in liver cirrhosis tissue due to diverse etiologies.…”

Section: Function Of Trp Channels In the Liver Trpv Channelsmentioning

confidence: 63%

Role of TRP Channels in Metabolism-Related Diseases

Wu,

Bu,

Wang

2024

IJMS

View full text Add to dashboard Cite

Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human health. The early identification of pathological abnormalities related to MetS and prevention of the risk of associated diseases is of paramount importance. Transient Receptor Potential (TRP) channels, a type of nonselective cation channel, are expressed in a variety of tissues and have been implicated in the onset and progression of numerous metabolism-related diseases. This study aims to review and discuss the expression and function of TRP channels in metabolism-related tissues and blood vessels, and to elucidate the interactions and mechanisms between TRP channels and metabolism-related diseases. A comprehensive literature search was conducted using keywords such as TRP channels, metabolic syndrome, pancreas, liver, oxidative stress, diabetes, hypertension, and atherosclerosis across various academic databases including PubMed, Google Scholar, Elsevier, Web of Science, and CNKI. Our review of the current research suggests that TRP channels may be involved in the development of metabolism-related diseases by regulating insulin secretion and release, lipid metabolism, vascular functional activity, oxidative stress, and inflammatory response. TRP channels, as nonselective cation channels, play pivotal roles in sensing various intra- and extracellular stimuli and regulating ion homeostasis by osmosis. They present potential new targets for the diagnosis or treatment of metabolism-related diseases.

show abstract

“…However, these effects are not seen in the liver of TRPV1 knockout mice [150]. Regarding glucose metabolism, the TRPV1 channel is an intrinsic component of the glucagon signaling pathway, and its absence is associated with increased glycogen production through PKA signaling [151]. Some studies have the opposite view.…”

Section: Transient Receptor Potential Channelsmentioning

confidence: 99%

The Role of Cannabidiol in Liver Disease: A Systemic Review

Chen,

Kim

2024

IJMS

View full text Add to dashboard Cite

Cannabidiol (CBD), a non-psychoactive phytocannabinoid abundant in Cannabis sativa, has gained considerable attention for its anti-inflammatory, antioxidant, analgesic, and neuroprotective properties. It exhibits the potential to prevent or slow the progression of various diseases, ranging from malignant tumors and viral infections to neurodegenerative disorders and ischemic diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and viral hepatitis stand as prominent causes of morbidity and mortality in chronic liver diseases globally. The literature has substantiated CBD’s potential therapeutic effects across diverse liver diseases in in vivo and in vitro models. However, the precise mechanism of action remains elusive, and an absence of evidence hinders its translation into clinical practice. This comprehensive review emphasizes the wealth of data linking CBD to liver diseases. Importantly, we delve into a detailed discussion of the receptors through which CBD might exert its effects, including cannabinoid receptors, CB1 and CB2, peroxisome proliferator-activated receptors (PPARs), G protein-coupled receptor 55 (GPR55), transient receptor potential channels (TRPs), and their intricate connections with liver diseases. In conclusion, we address new questions that warrant further investigation in this evolving field.

show abstract

Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes

Cited by 9 publications

References 110 publications

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Role of TRP Channels in Metabolism-Related Diseases

The Role of Cannabidiol in Liver Disease: A Systemic Review

Contact Info

Product

Resources

About