Lack of transparency in clinical trials: a call for action

Ramírez, Jorge H

doi:10.25100/cm.v44i4.1475

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…52 A call for more transparency in clinical trials and adherence to appropriate guidelines is also reported elsewhere. 53 If the template for the intervention description and replication is followed, the replicability may improve, thus making it possible to build on prior research findings. 54 Evaluating TCIs provides insight into whether interventions reduce readmissions among intervention groups compared with control groups.…”

Section: Limitation Of Included Evidence Basementioning

confidence: 99%

Impact of transitional care interventions on hospital readmissions in older medical patients: a systematic review

Rasmussen¹,

Grode²,

Lange³

et al. 2021

BMJ Open

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ObjectivesTo identify and synthesise available evidence on the impact of transitional care interventions with both predischarge and postdischarge elements on readmission rates in older medical patients.DesignA systematic review.MethodInclusion criteria were: medical patients ≥65 years or mean age in study population of ≥75 years; interventions were transitional care interventions between hospital and home with both predischarge and postdischarge components; outcome was hospital readmissions. Studies were excluded if they: included other patient groups than medical patients, included patients with only one diagnosis or patients with only psychiatric disorders. PubMed, The Cochrane Library, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Web of Science were searched from January 2008 to August 2019. Study selection at title level was undertaken by one author; the remaining selection process, data extraction and methodological quality assessment were undertaken by two authors independently. A narrative synthesis was performed, and effect sizes were estimated.ResultWe identified 1951 records and included 11 studies: five randomised trials, four non-randomised controlled trials and two pre–post cohort studies. The 11 studies represent 15 different interventions and 29 outcome results measuring readmission rates within 7–182 days after discharge. Twenty-two of the 29 outcome results showed a drop in readmission rates in the intervention groups compared with the control groups. The most significant impact was seen when interventions were of high intensity, lasted at least 1 month and targeted patients at risk. The methodological quality of the included studies was generally poor.ConclusionTransitional care interventions reduce readmission rates among older medical patients although the impact varies at different times of outcome assessment. High-quality studies examining the impact of interventions are needed, preferably complimented by a process evaluation to refine and improve future interventions.PROSPERO registration numberCRD42019121795.

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Section: Limitation Of Included Evidence Basementioning

confidence: 99%