Lack of toxicological side-effects in silver-coated megaprostheses in humans

Hardes, Jendrik; Ahrens, H.; Gebert, Carsten; Streitbuerger, Arne; Buerger, Horst; Erren, Michael; Günsel, Andreas; Wedemeyer, Christian; Saxler, Guido; Winkelmann, Winfried; Gosheger, Georg

doi:10.1016/j.biomaterials.2007.02.033

Cited by 285 publications

(239 citation statements)

References 35 publications

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“…Journal of Surgical Oncology metastases [9]. The positive results of these earlier studies made routine use of silver-coated megaprostheses possible in our department.…”

Section: Discussionmentioning

confidence: 87%

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Reduction of periprosthetic infection with silver‐coated megaprostheses in patients with bone sarcoma

Hardes

Eiff

Streitbuerger

et al. 2010

Journal of Surgical Oncology

301

225

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Background and Objectives: The placement of megaprostheses in patients with bone sarcoma is associated with high rates of infection, despite prophylactic antibiotic administration. In individual cases, secondary amputation is unavoidable in the effort to cure infection. Methods: The infection rate in 51 patients with sarcoma (proximal femur, n ¼ 22; proximal tibia, n ¼ 29) who underwent placement of a silver-coated megaprosthesis was assessed prospectively over a 5-year period, along with the treatment administered for infection. The infection rate was compared with the data for 74 patients in whom an uncoated titanium megaprosthesis (proximal femur, n ¼ 33; proximal tibia, n ¼ 41) was implanted. Results: The infection rate was substantially reduced from 17.6% in the titanium to 5.9% in the silver group. Whereas 38.5% of patients in the titanium group ultimately had to undergo amputation when periprosthetic infection developed, these mutilating surgical procedures were not necessary in the study group. Conclusions: The use of silver-coated prostheses reduced the infection rate in the medium term. In addition, less aggressive treatment of infection was possible in the group with silver-coated prostheses. Further studies with longer term follow-up periods and larger numbers of patients are warranted in order to confirm these encouraging results.

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“…Journal of Surgical Oncology metastases [9]. The positive results of these earlier studies made routine use of silver-coated megaprostheses possible in our department.…”

Section: Discussionmentioning

confidence: 87%

“…Toxicological side effects in patients receiving a silver-coated tumor endoprosthesis have been excluded in previous studies [9], and high antimicrobial activity of the silver coating has been demonstrated in a rabbit model [4]. However, a lack of effectiveness has also been reported [10,11].…”

Section: Introductionmentioning

confidence: 99%

Reduction of periprosthetic infection with silver‐coated megaprostheses in patients with bone sarcoma

Hardes

Eiff

Streitbuerger

et al. 2010

Journal of Surgical Oncology

301

225

View full text Add to dashboard Cite

show abstract

“…Silver-coated megaprostheses in animal models and humans [13,15] and iodine-supported titanium implants [31] have recently been developed and are expected to prevent postoperative deep infection. Dislocation and aseptic loosening of endoprostheses are other major postoperative complications.…”

Section: Discussionmentioning

confidence: 99%

Constrained Total Hip Megaprosthesis for Primary Periacetabular Tumors

Ueda

Kakunaga

Takenaka

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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“…Low concentrations (<35 ppb) are reported to be bactericidal [34], whilst higher concentrations between 1 ppm and 10 ppm may cause damage to human cells, ranging from low localised toxicity to conditions like argyria in higher doses (>4-6 g in the body) [35]. Histopathologic examination of silver coated megaprostheses in humans showed no signs of local or systemic side-effects at concentrations up to 1627 ppb [36].…”

Section: Biofilm Growthmentioning

confidence: 97%