Lack of toxicity after paracetamol overdose in a extremely preterm neonate

Porta, Roser; Sánchez, L.; Nicolás, Marta Portal; García, Carmen Vega; Martínez, Marta

doi:10.1007/s00228-011-1165-6

Cited by 28 publications

(20 citation statements)

References 10 publications

(13 reference statements)

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“…It is assumed, that for complete safety, paracetamol administration during the neonatal period should be an occasional and restricted to 48–72 h (Brandlistuen et al, 2013). Such limitation is dictated by the poorer metabolic clearance and reduced elimination capacity of paracetamol by the newborn (Allegaert et al, 2008; Allegaert et al, 2009; Allegaert et al, 2011; Allegaert and Naulaers, 2010; Bucaretchi et al, 2014; Porta et al, 2012). Clinical observations indicate that adequate, well‐tolerated dose in neonates is approximately of 10–30 mg/kg b.w.…”

Section: Discussionmentioning

confidence: 99%

Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats—Focus on the spinal cord

Blecharz-Klin

Joniec-Maciejak

Jawna

et al. 2015

Intl J of Devlp Neuroscience

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The present study has examined the influence of the prenatal and early life administration of paracetamol on the level of neurotransmitters in the spinal cord of rat pups. The effect of the drug was evaluated in 2-month old Wistar male rats exposed to paracetamol in doses of 5 (P5, n=9) or 15 mg/kg (P15, n=9) p.o. during the prenatal period and after birth until the completion of the second month of life. A parallel control group received tap water (Con, n=9). In this study we have determined the level of monoamines, their metabolites and amino acids in the spinal cord of rats using high performance liquid chromatography (HPLC) in the second month of life. The present experiment demonstrates the action of paracetamol at the molecular level associated with significant modulation of neurotransmission in the spinal cord related to dopaminergic and noradrenergic systems. Simultaneously, paracetamol administration increases the content of an aspartic and glutamic acids in the spinal cord at a critical time during development.

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Section: Discussionmentioning

confidence: 99%

Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats—Focus on the spinal cord

Blecharz-Klin

Joniec-Maciejak

Jawna

et al. 2015

Intl J of Devlp Neuroscience

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“…Consequently, it is impossible to predict ''safe'' doses. 27,28 Pharmacokinetics studies with intravenous, rectal, and oral paracetamol indicated a prolonged serum halflife in pre-term infants. Therefore, dose adjustment is advised in this age group.…”

Section: Discussionmentioning

confidence: 99%

Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants

et al. 2014

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“…Intravenous paracetamol has been reported to raise liver enzymes transiently 6 and this adverse effect has already been reported in three neonates by Alan et al [27]. Even more worryingly, serious acute liver toxicity has already reported in preterm infants after intravenous use of paracetamol [28][29][30][31][32].…”

Section: Controversies and Concerns Regarding Use Of Paracetamol For mentioning

confidence: 99%

Paracetamol for the Treatment of Patent Ductus Arteriosus in Very Low Birth Weight Infants

Singh¹,

Gooding²

2016

J Neonatal Biol

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Persistent patent ductus arteriosus (PDA) is associated with significant co-morbidities and increased mortality in preterm infants, especially very low birth weight (VLBW) infants. A large number of studies on the management of PDA have been published. Despite PDA being such a common condition in preterm infants, there is no consensus on which PDAs to treat, when to treat and how best to treat. Nonspecific cyclo-oxygenase inhibitors such as indomethacin and ibuprofen have been the mainstay of medical treatment of PDA for decades. Ibuprofen has similar efficacy and higher safety profile when compared to indomethacin, as it is associated with fewer gastrointestinal and renal side effects, and is considered the drug of choice for PDA closure. Recently, there is a growing interest in paracetamol for PDA closure and it has been suggested as an alternative drug to treat PDA. Finding the optimal pharmacological treatment for PDA closure in VLBW continues to remain challenging. In this review article, we assessed the evidence of paracetamol for PDA closure VLBW infants.

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Lack of toxicity after paracetamol overdose in a extremely preterm neonate

Cited by 28 publications

References 10 publications

Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats—Focus on the spinal cord

Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats—Focus on the spinal cord

Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants

Paracetamol for the Treatment of Patent Ductus Arteriosus in Very Low Birth Weight Infants

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