Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion

Varla-Leftherioti, M.; Spyropoulou-Vlachou, Maria; Keramitsoglou, Theodora; Papadimitropoulos, Miltiadis; Tsekoura, Christina; Graphou, Olga; Papadopoulou, C.; Gerondi, M.; Stavropoulos-Giokas, Catherine

doi:10.1016/j.humimm.2004.10.005

Cited by 72 publications

(39 citation statements)

References 40 publications

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“…This was the first observation that indicates a clear relationship between HLA-C molecules expressed by fetal extravillous trophoblast and maternal dNK cell KIR receptors. Another report extended these observations, indicating that 60% of the women tested who had recurrent spontaneous abortion were lacking the KIR2DL1 inhibitory receptor [39]. These authors further showed that a lack of KIR2DL1 resulted in a lack of epitope matching between maternal inhibitory KIR and fetal extravillous trophoblast HLA-Cw alleles in 33% of the cases.…”

Section: Distinct Functions For Dnk Cells In Pregnancy?mentioning

confidence: 74%

HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Rabot

Tabiasco

Polgar

et al. 2005

Chemical Immunology and Allergy

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Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major subpopulation of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy expresses the polymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response.

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Section: Distinct Functions For Dnk Cells In Pregnancy?mentioning

confidence: 74%

HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Rabot

Tabiasco

Polgar

et al. 2005

Chemical Immunology and Allergy

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“…However, a role for several trophoblastic HLA-C alleles, together with maternal alleles of killer Ig-like receptors, in influencing reproductive success is made probable by studies of spontaneous abortions [62] and of pre-eclampsia, another serious pregnancy complication [63]. In addition to this recent progress in the field of human reproduction, it is obvious that the involvement of various chemoreceptors in detecting MHC-determined chemosensory cues within the nasal cavity [21,22,28], as well as the presence of functional ORs on spermatozoa [18,19], has opened an entirely new area of interdisciplinary research.…”

Section: Discussionmentioning

confidence: 99%

Female choice and the MHC

Ziegler

Kentenich

Uchańska-Ziegler

2005

Trends in Immunology

104

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“…2 The frequencies of Bx and AA genotypes of the study and control groups. While the frequency of AA genotype of the study group was significantly lower than the control group, the rate of Bx genotypes was significantly higher in the study group (p00,014) 3DL3 2DS2 2DL2 2DL3 2DP1 2DL1 3DP1 2DL4 3DL1 3DS1 2DL5 2DS3 2DS5 2DS1 2DS4 3DL2 number [18] et al [26] proposed that the cause of the miscarriage in women who had experienced an allo-immune abortus is that they have a limited number of inhibiting KIR repertoire and thus trophoblastic HLA class I molecules were not recognized by the decidual NK cells and perceived as foreign. Our study differed from this study as that inhibiting KIR genes did not show significant differences between the study and control groups.…”

Section: Discussionmentioning

confidence: 81%

“…Although few, there are studies showing the relationship between decreased inhibiting KIRs or increased activating KIR-HLA ligand relation and recurrent miscarriages [8,10,26,28]. Thus, KIR genotyping in women with a history of recurrent miscarriage might be important in order to understand these mechanisms and in processing a therapeutic approach.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of KIR genes in recurrent miscarriage

Öztürk

Şahin

Karaçor

et al. 2012

J Assist Reprod Genet

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Purpose Natural killer (NK) cells express killer immunoglobulinlike receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage. Methods The present study was carried out on 40 women who had unexplained recurrent miscarriage and 90 controls. Sequence-specific oligonucleotide probes analysis were used to investigate 16 KIR genes. All data were statistically analyzed by Fisher Exact Test. Results The rate of Bx genotypes that consists elevated number of activating KIR genes was significantly higher (p00.014) in women with recurrent miscarriage when compared with the control group. Additionally, the frequency of AA genotype (AA1) of the subjects in the study group was significantly lower than the frequency of the subjects in the control group (p00,014). Furthermore, there were no statistically significant differences in the frequencies of the individual KIR genes between women with recurrent miscarriage and the control group. Conclusions Inclined balance of KIRs toward an activating state in NK cells may contribute to recurrent miscarriage.

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Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion

Cited by 72 publications

References 40 publications

HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Female choice and the MHC

Evaluation of KIR genes in recurrent miscarriage

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