Lack of TGFβ signaling competency predicts immune poor cancer conversion to immune rich and response to checkpoint blockade
Jade Moore,
Jim Gkantalis,
Ines Guix
et al.
Abstract:Background: Transforming growth factor beta (TGFbeta) is well-recognized as an immunosuppressive player in the tumor microenvironment but also has a significant impact on cancer cell phenotypes. Loss of TGFbeta signaling impairs DNA repair competency, which is described by a transcriptomic score, BAlt. Cancers with high BAlt have more genomic damage and are more responsive to genotoxic therapy. The growing appreciation that cancer DNA repair deficits are important determinants of immune response prompted us to… Show more
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