Lack of Survival Benefit Following Adjuvant Radiation in Patients with Retroperitoneal Sarcoma: A SEER Analysis

The Benefit of Adjuvant Radiotherapy in High-grade Nonmetastatic Retroperitoneal Soft Tissue Sarcoma

“…8,15,[29][30][31] This represents the first study known to us that shows a survival benefit of RT in patients with high-grade RPS; other histologic grades were not analyzed as previous data have shown that high-grade disease was an independent predictor of mortality. 9 Although we could not assess local control (LC) in the SEER database, previous systemic review has shown "good evidence" that RT is associated with improved LC. 32 An earlier single-institution series showed that margin status was the only significant prognostic factor for 5-year OS, suggesting improving LC is likely related to improved OS.…”

“…15 In addition, multiple previous analyses of the Surveillance, Epidemiology, and End Results (SEER) database have shown that RT does not improve OS in patients with RPS. 7,9,16 As with other sarcomas, grade has prognostic significance. Patients with high-grade RPS at initial presentation are at an increased risk of locoregional recurrence and have decreased OS.…”

“…Not surprisingly, disease progression or local recurrences are common, and outcomes for patients with RPS are generally poor with 5-year overall survival (OS) ranging from 39% to 65%. [3][4][5][6][7][8][9][10] Aggressive, en bloc, gross total resection has been associated with improved OS, especially in patients with lower grade tumors. [11][12][13] As is the case with other STS, the role of chemotherapy is limited.…”

A retrospective, single‑center cohort study on 65�patients with primary retroperitoneal liposarcoma

“…The majority of patients with PRPLS are diagnosed at an advanced disease stage, therefore PRPLS tumors often grow to a large size and have invaded adjacent organs upon diagnosis (22). The benefits of using adjuvant chemotherapy and radiation therapy to treat PRPLS remains controversial (23,24). A number of studies have suggested that chemotherapy may worsen patient prognosis (25,26).…”

Sarcomas

“…In retroperitoneal soft tissue sarcomas (RPS) institutional series with intraoperative radiotherapy, proton or carbon ion therapy have produced promising results (Sindelar et al 1993 ;Petersen et al 2002 ;Pawlik et al 2006 ;Serizawa et al 2009 ;Yoon et al 2010 ;Pezner et al 2011 ), though the data from epidemiological studies is confl icting (Sampath et al 2010 ;Tseng et al 2011 ). The current concept of preoperative radiotherapy is especially helpful in retroperitoneal STS, as the tumor displaces the surrounding bowel, the normal tissues with tumor contact are in place for target volume defi nition, and the limited total dose of 50 Gy is feasible in the abdomen (Pawlik et al 2006 ).…”