Lack of significant seasonal association between serum 25(OH)D concentration, muscle mass and strength in postmenopausal women from the D-FINES longitudinal study

Abstract

The aim of the present study was to assess the seasonal relationship between serum 25(OH)D concentration, lean mass and muscle strength. This was a secondary data analysis of a subgroup of 102 postmenopausal women participating in the 2006–2007 D-FINES (Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in Southern England) study. The cohort was assessed as two age subgroups: <65 years (n=80) and ≥65 years (n=22). Outcome measures included lean mass (DXA), muscle strength (handgrip dynamometry) and serum 25(OH)D concentration (enzymeimmunoassay). Derived outcomes included appendicular skeletal muscle mass (ASM) and relative appendicular skeletal muscle index (RASM). Sarcopenia status was assessed using the European Working Group on Sarcopenia in Older People 2018 criteria. Non-parametric partial correlation using BMI as a covariate was used to evaluate the study aims. There were no statistically significant associations between total lean mass, ASM or RASM and 25(OH)D in any group at any season. There was a trend for handgrip strength to be positively associated with serum 25(OH)D concentration. There was a trend showing a higher prevalence of sarcopenia in women ≥65 years. Sarcopenia status appeared transient for five women. In conclusion, the present study found no significant association between vitamin D status and functional indicators of musculoskeletal health, which were additionally not affected by season.

Vitamin D Inadequacy Affects Skeletal Muscle Index and Physical Performance in Lumbar Disc Degeneration

“…Sufficient circulating vitamin D can result in enhancing and prolonging physical ability. However, a recent study evinced that serum 25(OH)D levels were not related to muscle mass and strength [ 29 ]. Welford and coworkers found that circulating vitamin D status was not correlated with appendicular skeletal muscle mass in postmenopausal women [ 29 ].…”

“…However, a recent study evinced that serum 25(OH)D levels were not related to muscle mass and strength [ 29 ]. Welford and coworkers found that circulating vitamin D status was not correlated with appendicular skeletal muscle mass in postmenopausal women [ 29 ]. These conflicting findings may be ascribed to differences in populations, physical activity, various seasons of sample collection, and/or the measurements applied.…”

Investigating seasonal association between vitamin D concentration, muscle mass and strength in postmenopausal women: a critical analysis

“…We read with pleasure the article by Welford et al (1) , titled ‘ Lack of significant seasonal association between serum 25(OH)D concentration, muscle mass and strength in postmenopausal women from the D-FINES longitudinal study ’ and would like to offer additional commentary on the extrapolated conclusions regarding the influence of diet, sun exposure, skin pigmentation and genetics in vitamin D serum concentrations and downstream impact on muscle mass and strength in postmenopausal women. We hope that these perspectives may provide insight into areas that may require further research and development.…”