Lack of Response to Isotretinoin in Annular Elastolytic Giant Cell Granuloma

Abstract

Annular elastolytic giant cell granuloma is a rare disease characterized by annular configurated lesions with typical histopathologic findings. We report a case of annular elastolytic giant cell granuloma in a 50-year-old male patient. Treatment modalities for this disease are limited and mostly unsatisfactory, although isotretinoin was found to be effective in a single case. However, systemic isotretinoin treatment of 12 weeks' duration was of no benefit in the presented case.

Elastolytic Actinic Giant Cell Granuloma

“…79,80 Hydroxychloroquine [81][82][83][84] and chloroquine 20,26 have also shown positive results, although there are also cases with no response to antimalarials. 12 Failure to isotretinoin, 85 methotrexate, 73 PUVA, 51,69 and cryotherapy 86 has also been reported.…”

Effective treatment with hydroxychloroquine in a case of annular elastolytic giant cell granuloma

“…[2,3,[9][10][11][12][13][14] In contrast, topical corticosteroids, PUVA, cauterization, cryotherapy, methotrexate, and isotretinoin were found to be unsuccessful. [2,15] In addition to that, clofazimine has been reported as both effective [16] and ineffective [2] in two separate cases.…”

Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature

“…The pathogenesis of AEGCG remains unclear; but it is thought that ultraviolet radiation, heat or other factors might change the antigenicity of elastic fibres and induce a cellular immune reaction 1 . In addition, there have been reports of AEGCG associated with systemic disorders 2–5 . We report a case of AEGCG in a patient with newly diagnosed diabetes mellitus (DM), and review the cases of AEGCG in the Japanese literature.…”

“…Thus, DM may be a precipitating factor for AEGCG, possibly contributing to structural damage of the elastic fibres. Only a few cases of AEGCG associated with DM have been reported in the English literature 4,5 . Further studies are needed to clarify the relationship between AEGCG and DM.…”