Lack of relationship between β3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population

Tsai, Po Jung; Ho, Su Chen; Tsai, Li Ping; Lee, Yu Hsiang; Hsu, Shih Penn; Yang, Su Pan; Chu, Chun Hong; Yu, Chun Hsien

doi:10.1016/j.metabol.2004.04.006

Cited by 20 publications

(16 citation statements)

References 22 publications

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“…37 The Arg64 allele frequency was also comparable between 309 white women with GDM and 277 women with normal glucose tolerance. 63 Similar findings were obtained by Tsai et al 88 in a cohort of 299 Taiwanese women: 258 with normal glucose tolerance and 41 with GDM. Although Arg64 carriers with GDM had higher fasting and 120-minute postload insulin levels than did homozygotes for the wild-type allele, the Arg64 allele frequency was similar in the control and the GDM groups (0.145 vs. 0.098, P ϭ 0.086).…”

Section: ␤-3 Adrenergic Receptor (Adrb3)supporting

confidence: 78%

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

Robitaille

Grant

2008

Genetics in Medicine

126

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Gestational diabetes is a major public health problem because of its prevalence, its associated complications during pregnancy, and its increased risk for type 2 diabetes later in life. Insulin resistance is one of many physiological changes occurring during pregnancy, and when insulin resistance is accompanied by pancreatic ␤-cell insufficiency, gestational diabetes may develop. Several lines of evidence suggest that gestational diabetes shares a common etiology with type 2 diabetes and support the hypothesis that gestational diabetes serves as a window to reveal a predisposition to type 2 diabetes. Pregnancy is an environmental stressor that may catalyze the progression to a diabetic state in genetically predisposed women; therefore, identification of these women during pregnancy could decrease the occurrence of type 2 diabetes through targeted prevention. This review presents an overview of the genetics of gestational diabetes, focusing on human association studies with candidate genes common to both type 2 diabetes and gestational diabetes. Genet Med 2008:10(4):240 -250. Key Words: gestational diabetes mellitus, type 2 diabetes, genetics, pregnancy, association studiesGestational diabetes mellitus (GDM) is a major public health problem because of its prevalence and its associated complications during pregnancy. It is estimated that 4% of pregnancies in the United States are complicated by GDM, although the prevalence of GDM varies considerably among racial and ethnic groups. 1 Uncontrolled GDM increases the risk of adverse neonatal outcomes such as macrosomia, birth injuries, neonatal hypoglycemia, neonatal cardiac dysfunction, and stillbirth. 2 In addition to increasing the risk of adverse infant outcomes, GDM also has high predictive value for later development of type 2 diabetes (T2D) in the mother and in her offspring. Women who experience GDM have increased risk of developing T2D after pregnancy, ranging from 17% to 63% within 5-16 years after pregnancy depending on the population and other risk factors. 3 Additionally, offspring of mothers with GDM are more likely to be obese and display impaired glucose tolerance during adolescence than are offspring of nondiabetic mothers. Thus, diabetes during pregnancy is not only associated with the later risk of diabetes in mothers but also with metabolic changes that may lead to the development of diabetes in their offspring. 4 This observed connection between GDM and risk of T2D strongly suggests that GDM can serve as a window revealing a predisposition to T2D, with pregnancy as the environmental stressor that catalyzes progression to a diabetic state in predisposed individuals. 5 Several lines of evidence support the above hypothesis. First, GDM shares several risk factors with T2D, including high body mass index (BMI), history of abnormal glucose tolerance, diabetes in a first-degree relative, and membership in an ethnic group with a high risk of T2D. 6 Second, GDM and T2D share similar pathophysiologies: women undergo major physiological changes during pregn...

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Section: ␤-3 Adrenergic Receptor (Adrb3)supporting

confidence: 78%

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

Robitaille

Grant

2008

Genetics in Medicine

126

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“…In addition, the Trp64Arg polymorphism has been associated with 'mild' gestational diabetes mellitus in Austrian [25], but not in Greek [26], Taiwanese [27] or Italian [28] women. However, it was associated with increased weight gain and increased glucose and insulin levels during pregnancy [25,27]. The present study failed to find a role of this variant in the risk of gestational diabetes mellitus in Scandinavian women.…”

Section: Adrb3 Trp64argmentioning

confidence: 91%

“…Analysis of subsequent studies has shown an association of this polymorphism with features of the metabolic syndrome [40]. In addition, the Trp64Arg polymorphism has been associated with 'mild' gestational diabetes mellitus in Austrian [25], but not in Greek [26], Taiwanese [27] or Italian [28] women. However, it was associated with increased weight gain and increased glucose and insulin levels during pregnancy [25,27].…”

Section: Adrb3 Trp64argmentioning

confidence: 99%

“…These polymorphisms were the transcription factor 7-like 2 (TCF7L2 rs7903146) [12][13][14][15][16][17][18][19], adiponectin (ADIPOQ +276G>T) [20,21], peroxisome-proliferator activated receptor (PPAR), gamma 2 (PPARG Pro12Ala) [22], PPARG-coactivator 1, alpha (PPARGC1A Gly482Ser) [23] and forkhead box C2 (FOXC2 −512C>T) [24]. Despite its MAF~10%, we also included the β3-adrenergic receptor (ADRB3 Trp64Arg) polymorphism, as its putative association with gestational diabetes mellitus has been addressed in a number of small studies with inconsistent results [25][26][27][28]. These polymorphisms were genotyped in a case-control study of 1,881 unrelated pregnant Scandinavian women (649 with gestational diabetes mellitus, 1,232 non-diabetic control subjects).…”

Section: Introductionmentioning

confidence: 99%

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A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus

et al. 2007

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Aims/hypothesis Genetic and epidemiological studies suggest an association between gestational diabetes mellitus and type 2 diabetes. Both are polygenic multifactorial disorders characterised by beta cell dysfunction and insulin resistance. Our aim was to investigate whether common genetic variants that have previously been associated with type 2 diabetes or related phenotypes would also confer risk for gestational diabetes mellitus. Materials and methods In 1,881 unrelated pregnant Scandinavian women (649 women with gestational diabetes mellitus, 1,232 non-diabetic control subjects) we genotyped the transcription factor 7-like 2 (TCF7L2 rs7903146), adiponectin (ADIPOQ +276G>T), peroxisome-proliferator activated receptor, gamma 2 (PPARG Pro12Ala), PPARGcoactivator, 1 alpha (PPARGC1A Gly482Ser), forkhead box C2 (FOXC2 −512C > T) and β3-adrenergic receptor (ADRB3 Trp64Arg) polymorphisms using TaqMan allelic discrimination assay or RFLP.

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“…Also, an association with the ADRB3 W64R variant could not be replicated in subsequent studies [29,30]. However, this might be due to lack of power, given the small effect size of most common variants, or due to ethnic heterogeneity between different populations.…”

Section: Introductionmentioning

confidence: 97%

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus

et al. 2005

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Aims/hypothesis: Gestational diabetes mellitus (GDM) and type 2 diabetes share a common pathophysiological background, including beta cell dysfunction and insulin resistance. In addition, women with GDM are at increased risk of developing type 2 diabetes later in life. Our aim was to investigate whether, like type 2 diabetes, GDM has a genetic predisposition by studying five common polymorphisms in four candidate genes that have previously been associated with type 2 diabetes. Materials and methods: We studied 1,777 unrelated Scandinavian women (588 with GDM and 1,189 pregnant non-diabetic controls) for polymorphisms in the genes encoding potassium inwardly rectifying channel subfamily J, member 11 (KCNJ11 E23K), insulin receptor substrate 1 (IRS1 G972R), uncoupling protein 2 (UCP2 −866G→A) and calpain 10 (CAPN10 SNP43 and SNP44). Results: The EE, EK and KK genotype frequencies of the KCNJ11 E23K polymorphism differed significantly between GDM and control women (31.5, 52.7 and 15.8% vs 37.3, 48.8 and 13.9%, respectively; p=0.050). In addition, the frequency of the K allele was increased in women with GDM (odds ratio [OR]=1.17, 95% CI 1.02−1.35; p=0.027), and this effect was greater under a dominant model (KK/EK vs EE) (OR=1.3, 95% CI 1.05−1.60; p=0.016). Analysis of the IRS1 G972R polymorphism showed that RR homozygosity was found exclusively in women with GDM (91.0, 8.3 and 0.7% vs 90.7,9.3 and 0.0% for GG, GR and RR genotypes, respectively; p=0.014). The genotype and allele frequencies of the other polymorphisms studied were not statistically different between the GDM and control women. Conclusions/interpretation: The E23K polymorphism of KCNJ11 seems to predispose to GDM in Scandinavian women.

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Lack of relationship between β3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population

Cited by 20 publications

References 22 publications

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

The genetics of gestational diabetes mellitus: evidence for relationship with type 2 diabetes mellitus

A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus

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