Lack of Relation of Survivin Gene Expression with Survival and Surgical Prognostic Factors in Endometrial Carcinoma Patients

Aksoy, Rıfat Taner; Thran, Ahmet Taner; Boran, Nurettin; Tokmak, Aytekin; Isikdogan, Betul Zuhal; Dogan, Mehmet; Thlunay, Hakki Gokhan

doi:10.7314/apjcp.2014.15.16.6905

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Others argue that lymphadenectomy carries a risk of severe complications such as lymphedema or lymphocyst formation, especially in women with endometrial cancer, who often have comorbidities such as obesity, hypertension and diabetes (Aksoy et al, 2014), and, lymphadenectomy is not necessary in women at low risk of lymph node involvement (stage 1a-1c), (Christopher et al, 2008).…”

Section: Accuracy Of Sentinel Node In Detecting Lymph Node Metastasis In Primary Endometrial Carcinomamentioning

confidence: 99%

Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma

Farghali

Allam²,

Abdelazim³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Endometrial carcinoma is the most common gynecological cancer and its treatment is still controversial, especially in its early stages. There are conflicting data about the efficacy of retroperitoneal lymphadenectomy during abdominal hysterectomy and bilateral salpingoophrectomy treatment. Lymphadenectomy carries a risk of severe complications, especially in women with co-morbidities. Selective lymphadenectomy has been widely employed for staging evaluation of endometrial carcinoma because it is simple and seems to provide reliable data regarding nodal metastasis. This study was designed to evaluate accuracy of sentinel node sampling in detecting lymph node metastasis in primary endometrial carcinoma during staging laparotomy. Materials and Methods: Ninety-three women with endometrial carcinoma at high-risk for nodal metastasis were studied. During laparotomy, methylene blue dye was injected into sub-serosal myometrium, then retroperitoneal spaces were opened and blue lymph nodes within pelvic and para-aortic regions were removed as separate specimens for histopathological examination (sentinel lymph nodes = SLNs). Hysterectomy and selective lymphadenectomy then performed for all women included in this study. Results: Deposition of methylene dye into at least one lymph node was observed in 73.1% (68/93) of studied cases. 18.3% (17/93) of studied women had positive lymph node metastasis and 94.1% (16/17) of them had positive metastasis in SLNs. In this study, SNLs had 94.4% sensitivity and 100% specificity in prediction of lymph node metastasis. Mean number of lymph nodes removed from each case decreased when SLNs biopsy were taken. Conclusions: SLNs are the key lymph nodes in endometrial tumor metastasis and their involvement could be an indicator for whether or not complete systematic lymphadenectomy is needed during staging laparotomy.

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Section: Accuracy Of Sentinel Node In Detecting Lymph Node Metastasis In Primary Endometrial Carcinomamentioning

confidence: 99%

Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma

Farghali

Allam²,

Abdelazim³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…[4] The authors argue that the retroperitoneal lymphadenectomy increases the intraoperative and postoperative complications. [5]…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph nodes in endometrial cancer update 2018

Abdelazim

Abu-Faza²,

Zhurabekova

et al. 2019

Gynecol Minim Invasive Ther

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There are no established data about lymphadenectomy during treatment of endometrial cancers (ECs) and to what extent lymphadenectomy should be performed. In addition, retroperitoneal lymphadenectomy increases the intraoperative and postoperative complications. Sentinel lymph node (SLN) mapping has the lowest costs and highest quality-adjusted survival. SLN is the most cost-effective strategy in the management of low-risk ECs. Women staged with SLN mapping were more likely to receive adjuvant treatment compared with women staged with systemic lymphadenectomy. This review article designed to evaluate the diagnostic accuracy and the methods of SLN detection in ECs.

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“…Their results were supported by Yilmaz et al (39) as they did not find any association between survivin expression and the clinical prognostic factors including lymphovascular space involvement and extrauterine spread of disease or survival. Aksoy et al (42), found no statistical association between survival and prognostic factors such as histological grade, stage, or cytoplasmic and nuclear expression of survivin in endometrial carcinomas. All these differences with regard to the prognostic role of survivin in endometrial carcinoma may be due to different concomitant genetic alterations and different molecular pathways taking place during endometrial carcinogenesis and metastatic expansion.…”

Section: Discussionmentioning

confidence: 96%

“…Since the findings in the literature are conflicting with respect to the prognostic value of survivin expression in endometrial carcinomas, in the present study, immunohistochemical staining was performed to investigate the distribution of survivin expression in primary endometrial carcinomas from Greek patients who underwent surgery and the survivin protein expression levels were analyzed in association with well-established clinicopathological prognostic factors (16,(36)(37)(38)(39)(40)(41)(42). Furthermore, in order to gain better insight into the synergistic function of survivin with tumor suppressor genes, the effects of PTEN and p53 expression, which had been previously evaluated by immunohistochemical analysis (43), were investigated on the expression of survivin in endometrial carcinomas.…”

Section: Expression Of Anti-apoptotic Protein Survivin In Human Endommentioning

confidence: 99%

Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression

et al. 2020

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Endometrial carcinoma is one of the most common types of gynecological cancer. A total of 99 cases of primary endometrial carcinoma were investigated for survivin expression by immunohistochemistry. Furthermore, the association between concomitant survivin, PTEN and p53 expression, and clinicopathological parameters was examined. Immunopositivity for survivin was identified in 88% of cases. Concomitant survivin, PTEN and p53 expression (staining scores and intensity) was observed in 60% of endometrial adenocarcinomas. A significant association was identified between the sum of staining intensity and scores of survivin immunopositive cells, and patient age (P=0.028), histological grade (P<0.001), clinical stage (P= 0.018) and fallopian tube and/or ovarian invasion (P=0.039). A negative tendency for correlation was observed between surivin and PTEN immunostaining scores (P=0.062; ρ=-0.238). Specimens with high scores of survivin expression tended to show decreased scores of PTEN immunostaining, and vice versa. However, in circumstances with an increased co-expression of survivin and PTEN, a statistically significant association with histological types was observed (P=0.020). A statistically significant positive correlation was identified between survivin and p53 sum co-expression (P=0.008; ρ= 0.300). Furthermore, a significant association was identified between survivin and p53 concomitant sum expression and age of patients (P=0.001), histological type (P=0.020), clinical stage (P=0.037), histological differentiation (P=0.001) and presence of fallopian tube and/or ovarian invasion (P= 0.026). The present findings suggested that survivin may be an indicator of unfavorable outcome in older patients with endometrial carcinoma, in specific circumstances that are dependent on different concomitant genetic alterations and different combinations of molecular signaling pathways. Increased expression levels of survivin and PTEN may serve a role in the development of more aggressive endometrial carcinoma during their interaction. In addition, protein expression levels of survivin and p53 are positively correlated and may share a common molecular pathway to promote endometrial carcinogenesis. These findings provided evidence that survivin and p53 combined may be useful markers for the prediction of tumor behavior and prognosis.

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Lack of Relation of Survivin Gene Expression with Survival and Surgical Prognostic Factors in Endometrial Carcinoma Patients

Abstract: non-disease survival.

Cited by 5 publications

References 15 publications

Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma

Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma

Sentinel lymph nodes in endometrial cancer update 2018

Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression

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