Lack of prominent compensatory polycythemia in traditional native andeans living at 4,200 meters

Garruto, Ralph M.; Dutt, James S.

doi:10.1002/ajpa.1330610310

Cited by 31 publications

(19 citation statements)

References 24 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is not surprising, since an increase of hemoglobin concentration, erythrocytes, and hematocrit with altitude is very well documented (Arnaud et al, 1981;Ballew et al, 1989;Beall et al, 1987Beall et al, , 1992Beall and Reichsman, 1984;Garruto and Dutt, 1983;Tarazona-Santos et al, 2000;Winslow and Monge, 1987). However, other studies have discussed the possibility that Himalayan highlanders may not exhibit as large an increase in hemoglobin concentration as is found in the Andes, and that they have only a slight increase in Hb with respect to their lowland counterparts (Beall et al, 1983Beall, 1993;Frisancho, 1988).…”

Section: Hematological Variablesmentioning

confidence: 58%

Lung volume, chest size, and hematological variation in low-, medium-, and high-altitude Central Asian populations

Fiori

Facchini

Ismagulov

et al. 2000

Am. J. Phys. Anthropol.

View full text Add to dashboard Cite

To evaluate adaptive responses to high-altitude environment, we examined three groups of healthy adult males from Central Asia: 94 high-altitude (HA) Kirghiz subjects (3,200 m above sea level); 114 middle-altitude (MA) Kazakh subjects (2,100 m), and 90 low-altitude (LA) Kirghiz subjects (900 m). Data on chest size (chest perimeter and chest diameter), lung volume (forced expiratory volume (FEV) and forced expiratory volume in 1 sec (FEV1)), and hematological parameters (hemoglobin, erythrocytes, hematocrit, and SaO(2)) are discussed. The results show that 1) chest shape is less flat in the samples living at higher altitude. In the HA sample, chest perimeter is lower but chest excursion is high. 2) In the highlanders, forced vital capacity (FVC) and FEV1 are no higher than in the other samples, even when corrected for stature and body weight. The negative correlation between FVC-FEV1 and age decreases with increasing altitude. 3) The HA and MA samples have higher values of hemoglobin, erythrocytes, and hematocrit. The HA sample has lower SaO(2) and higher arterial oxygen content than the LA sample. No association between hematocrit and age was detected in the four samples. The results indicate that the high-altitude Kirghiz present features of developmental acclimatization to hypobaric hypoxia which are also strongly influenced by other major high-altitude environmental stresses.

show abstract

Section: Hematological Variablesmentioning

confidence: 58%

Lung volume, chest size, and hematological variation in low-, medium-, and high-altitude Central Asian populations

Fiori

Facchini

Ismagulov

et al. 2000

Am. J. Phys. Anthropol.

View full text Add to dashboard Cite

show abstract

“…In contrast, virtually all the available Andean data are based on samples of miners and urban workers (see, e.g., Arnaud et al, 1981;Cosio, 1972;Hurtado et al, 1945;Torrance et al, 1971;Tufts et al, 1985;Winslow et al, 1981). These people are likely to have a variety of genetic backgrounds, distinctive diseases, activity patterns, and histories of exposure to altitude, some or all of which may contribute to the elevation of hemoglobin concentration (Garruto and Dutt, 1983). In this context, it is noteworthy that a rural Andean adult male sample following a traditional life-style at 4,000 m has a mean of 17.5 gm/dl, lower than all other Andean samples and insignificantly higher than a Himalayan value of 17 gm/dl at the same altitude (Adams and Strang, 1975;Garruto, 1976; t = 1.4; p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin concentration of pastoral nomads permanently resident at 4,850–5,450 meters in Tibet

Beall

Goldstein

1987

American J Phys Anthropol

View full text Add to dashboard Cite

This paper presents data on the hemoglobin concentration of a sample of 103 pastoral nomads who are lifelong residents of Phala, at 4,850-5,450 m, on the northern plateau of the Tibet Autonomous Region of the Peoples' Republic of China. This native population resides at the highest altitude of which we are aware and is thus exposed to the most extreme chronic hypoxic stress. However, they do not exhibit the most pronounced physiological adaptations, i.e., hemoglobin concentrations exceeding those found in all other high-altitude populations. Adult male and female mean hemoglobin concentrations of 18.2 and 16.7 gm/dl, respectively, were found. These data, in conjunction with earlier studies of ethnic Tibetans living at 3,400 m, demonstrate a pattern of increasing hemoglobin concentration (erythrocytosis) at increasing altitude of residence in the Himalayas and Tibet. At the same time, however, the hemoglobin concentration is lower than that found among Andean highlanders. These new data raise the possibility of quantitative population differences in hematological adaptation to high altitude hypoxia.

show abstract

“…Individuals whose values were lower than the 5th percentile or greater than the 95th percentile for WBC or for any of the differential counts were excluded from the analysis. The application of U.S. standards to Qinghai populations appears justified in light of reports of similar peripheral leukocyte and differential counts in different groups (Bain et al, 1984;Garruto and Dutt, 1983). Since EP was the only measure of iron status, the NHANES II sex and age-specific 90th percentile values were used as a conservative indicator of impaired iron status.…”

Section: Measurements and Methodsmentioning

confidence: 99%

Growth of Han migrants at high altitude in central Asia

Weitz

Garruto

2004

American J Hum Biol

View full text Add to dashboard Cite

Han Chinese of low-altitude descent have been living in Qinghai Province of Western China for at least two millennia. For most of this time they have lived at elevations under 2,500 m. However, during the last four decades an increasing number of Han have moved into high-altitude towns at elevations over 3,000 m, and some above 4,000 m. There are now sufficient numbers of Han descendants who have been born and raised at high altitude to allow a comparison of their morphological and physiological growth patterns with low-altitude Han to detect the effect of hypoxia. The field study reported here was conducted by collaborating Chinese and American researchers over a 6-year period, and included 1,227 Han living at high altitude in Qinghai and at low altitude near Beijing. This study demonstrates that Han born and raised at high altitude are smaller and lighter than those at low altitude-particularly as children and adolescents. Slower growth at high altitude may be a consequence of hypoxia, but it also corresponds to poorer economic conditions in rural Qinghai Province, and thus may reflect nutritional inadequacies. Differences in altitude and/or nutrition do not seem to affect thorax dimensions, since, relative to stature, chest dimensions are similar at both high and low altitudes. Nevertheless, lung volumes are higher among Han at high altitude, possibly reflecting the influence of hypoxia on alveolar growth. The hematological values of Han growing up at 3,200 m are not different from those at low altitude-an unusual finding relative to other low-altitude groups that may reflect population differences in response to hypoxia. At 3,800 m and 4,300 m, however, Han show elevated hemoglobin relative to Han at low altitude.

show abstract

Lack of prominent compensatory polycythemia in traditional native andeans living at 4,200 meters

Cited by 31 publications

References 24 publications

Lung volume, chest size, and hematological variation in low-, medium-, and high-altitude Central Asian populations

Lung volume, chest size, and hematological variation in low-, medium-, and high-altitude Central Asian populations

Hemoglobin concentration of pastoral nomads permanently resident at 4,850–5,450 meters in Tibet

Growth of Han migrants at high altitude in central Asia

Contact Info

Product

Resources

About