Lack of Prognostic Value of Human Epidermal Growth Factor- Like Receptor 2 Status in Inflammatory Breast Cancer (IBC): a Meta-analysis

Background: There is still a great deal of controversy with regard to the prognostic role of chemotherapyinduced amenorrhea (CIA) in breast cancer patients. To confirm whether CIA can serve as a useful factor in predicting clinical effects of systemic adjuvant chemotherapy, we performed this meta-analysis. Materials and Methods: Relevant studies were identified using PubMed, and Embase databases. Eligible study results were pooled and summary hazard ratios (HRs) with corresponding confidence intervals (CIs) were calculated. Subgroup analyses and an assessment of publication bias were also conducted. Results: A total of 8,333 patients from 11 published studies were identified through searching the databases. The pooled HRs for disease-free survival (DFS) suggested that CIA was associated with a significant reduction in the risk of recurrence, especially in patients with hormone receptor-positive lesions (overall HR=0.65, 95%CI 0.53-0.80, I 2 = 41.3%). When the five studies reporting the HR for overall survival (OS) were pooled (n=4193), a favorable trend was found (HR=0.69, 95%CI 0.52-0.91, I 2 = 51.6%). No publication bias was observed in this study. Conclusions: This meta-analysis suggests that CIA predicts a better outcome in premenopausal hormone receptor-positive breast cancer patients.

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HER-2 Positive Breast Cancer - a Mini-Review

Asif

Sultana²,

Ahmed³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Currently, cancers are leading cause of death all over the world (Saber et al., 2015). Breast cancer is one of among all with increased incidence, high mortality rate, and high economic and social costs (Zainal et al., 2013). It is the most common type of cancer among females worldwide (Cetin et al., 2014).Breast cancer is actually the uncontrolled proliferation of cells which starts in breast cells and attains malignancy. Recently it has shown that breast cancer contributes 11% among all types of cancer diagnosed globally annually and it is one of the leading cause of death among women (Majeed et al., 2014). All women regardless of of their racial or ethnic origin or heritage are at risk of breast cancer (Asif et al., 2014). Approximately 1.7 million Women were diagnosed with breast cancer in 2012. It is the most frequently diagnosed cancer among women in 140 of 184 countries worldwide (Erbil et al., 2014). In high income countries, breast cancer is about 30% cause of cancer deaths and reported to be 29% of all cancer incidences (Al-Dubai et al., 2012). There were approximately 192,000 new diagnoses of breast cancer and 47,000 deaths in the USA in 2009. Breast cancer is a major public health problem in High Income Countries as well as the Low Income countries (Yusuf et al., 2013). Previous studies revealed that the mortality rate of the

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Lack of Prognostic Value of Human Epidermal Growth Factor- Like Receptor 2 Status in Inflammatory Breast Cancer (IBC): a Meta-analysis

Cited by 3 publications

References 28 publications

How to Define Inflammatory Breast Cancer: A Systematic Review

How to Define Inflammatory Breast Cancer: A Systematic Review

Prognostic Value of Chemotherapy-Induced Amenorrhea in Breast Cancer: a Meta-Analysis

HER-2 Positive Breast Cancer - a Mini-Review

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