Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats

Woo, Gye‐Hyeong; Shibutani, Makoto; Kuroiwa, Keiko; Lee, Kyoung-Youl; Takahashi, Miwa; Inoue, Kaoru; Fujimoto, Hitoshi; Hirose, Masao

doi:10.1016/j.fct.2007.02.010

Cited by 15 publications

(11 citation statements)

References 42 publications

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“…In the present study, ACR-induced neurotoxicity in maternal animals was evident from 100 ppm on morphometric assessment of the sciatic nerves and cerebellar molecular layer, as previously reported (Lee et al, 2005;Woo et al, 2007). Dams given ACR at concentrations of ≥100 ppm exhibited depression of body weight and food and water consumption in a dose-dependent fashion.…”

Section: Discussionsupporting

confidence: 63%

“…In the cerebellar molecular layer, increase of dot-like SYPimmunoreactive structures was observed from 100 ppm as reported previously ( Fig. 3E and F; Lee et al, 2005;Woo et al, 2007). However, the distribution of SYP-positive neuromuscular junctions in skeletal muscle did not differ among the groups.…”

Section: Maternal Toxicitysupporting

confidence: 68%

“…Rabbit polyclonal antibody Ab-4 (1: 200, Lab Vision Corp., Fremont, CA, USA) was used as the primary antibody and immunodetection was conducted with the horseradish peroxidase-avidinbiotin complex method utilizing a VECTASTAIN ® Elite ABC kit (Vector Laboratories Inc., Burlingame, CA, USA) with 3,3'-diaminobenzidine/H 2 O 2 as the chromogen, as described previously (Woo et al, 2007). In addition, SYPimmunoreactivity was also examined in skeletal muscle using formalin-fixed sections to evaluate the distribution of neuromuscular junctions.…”

Section: Immunohistochemistry For Synaptophisin (Syp) In the Cerebellmentioning

confidence: 99%

“…In humans, since exposure to ACR occurs through ingestion of food in general population, it is reasonable to examine toxic effects of such chemicals by oral administration through food or drinking water to experimental animals. In the present study, ACR was administered to maternal rats through drinking water with the dose levels in inducing histologically apparent neurotoxicity and testicular toxicity after 4 weeks administration in adult male SD rats in our previous studies (Lee et al, 2005;Woo et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study

et al. 2008

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-To evaluate the developmental effects of exposure to acrylamide (ACR) on the nervous and male reproductive systems, pregnant Sprague-Dawley rats were given ACR at 0, 50, 100 or 200 ppm in the drinking water from gestational day 10 to postnatal day 21 and histopathological assessment of offspring was performed at weaning and postnatal week 11. Neurotoxicity was quantitatively assessed with reference to nerve fiber density, percentages of degenerated and small caliber axons in the sciatic nerves, and numbers of aberrant dot-like structures immunoreactive for synaptophysin in the cerebellar molecular layer. Although maternal neurotoxicity was evident from 100 ppm, no changes suggestive of neurotoxicity or testicular toxicity were observed in offspring. However, lowering of body weights was dose-dependently observed from birth at the dose levels of ≥50 ppm in males and ≥100 ppm in females. Maternal malnutrition was apparent at ≥100 ppm during the lactation period. Therefore, poor lactational ACR-exposure due to maternal toxicity might account for the lack of ACR-induced offspring toxicity other than retarded body growth.

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Section: Discussionsupporting

confidence: 63%

Section: Maternal Toxicitysupporting

confidence: 68%

Section: Immunohistochemistry For Synaptophisin (Syp) In the Cerebellmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study

et al. 2008

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“…Dietary chlorophyllin was investigated for protective effects against acrylamide neurotoxicity in rats and no apparent beneficial activity of Cu-Chl was observed (Woo et al, 2007). None of the mechanisms of action of Cu-Chl previously described (interceptor molecule, radical scavenging, modulation of enzymatic activity) seems able to explain this lack of activity on acrylamide.…”

Section: Antagonistic Effects and Lack Of Bioactivitymentioning

confidence: 98%

Copper chlorophyllin: A food colorant with bioactive properties?

Tumolo

Lanfer-Marquez

2012

Food Research International

116

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Role of antioxidants and phytochemicals on acrylamide mitigation from food and reducing its toxicity

2014

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Nowadays, the presence of acrylamide in lots of fried and baked foods raises concerns due to its potential to cause toxicity and cancer in animals and human. Consequently, a number of papers have focused on evaluation of various chemicals in reduction of acrylamide in various food sources, as well as decreasing its related toxicities. In addition, plants are important sources of diverse metabolites demonstrating either possible effectiveness in acrylamide toxicity or reduction of acrylamide content in food sources. In this paper, we have criticized all relevant studies in terms of acrylamide mitigation from food by phytochemicals and antioxidants, and the influence of herbal medicines and phytopharmaceuticals on reduction of acrylamide toxicity in both animals and human.

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Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats

Cited by 15 publications

References 42 publications

Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study

Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study

Copper chlorophyllin: A food colorant with bioactive properties?

Role of antioxidants and phytochemicals on acrylamide mitigation from food and reducing its toxicity

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