Lack of pharmacokinetic interaction between vinpocetine and oxazepam.

Storm, Gerrit; Oosterhuis, B.; Sollie, Frans A. E.; Visscher, H. W.; Sommer, W.; Beitinger, H; Jonkman, J. H. G.

doi:10.1111/j.1365-2125.1994.tb04338.x

Cited by 2 publications

(3 citation statements)

References 17 publications

(17 reference statements)

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“…Up to the present, several publications have reported the interactions of vinpocetine with other clinical prescription drugs. According to Storm et al [ 16 ], multiple doses of vinpocetine showed no influence on the steady state plasma concentrations and kinetics of oxazepam but cause diurnal changes in the plasma binding of oxazepam without clinical consequences. The values of AUC 0− t , AUC 0−inf , and C max following the single administration of vinpocetine alone and after pretreatment of 5 days with omeprazole (10 mg/kg, intraperitoneally) were very similar in both groups [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacokinetic interactions arise when absorption, distribution, metabolism, or elimination of the involved drugs is altered, leading to changes in the amount and duration of drug availability at receptor sites. More precisely, the most common DDI of pharmacokinetics may be understood in terms of metabolic alterations, primarily associated with changes in the activity of cytochrome P450 (CYP) enzymes [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although there have been some investigations of DDI of vinpocetine [ 9 , 16 , 17 ], information on the CYP enzyme-mediated drug metabolism has not been previously studied. Owing to the fact that the use of in vitro data to predict the inhibition potential of a drug is wonderful with simple, convenient, and high throughput [ 18 ], the major objective of the present study was to investigate the effects of vinpocetine on the CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1 enzymes, which are primarily involved in drug metabolism, and then to predict any DDIs when vinpocetine is coadministered with other drugs metabolized by CYPs.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

Kong

Song

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Vinpocetine is a derivative of the alkaloid vincamine, which had been prescribed for chronic cerebral vascular ischemia and acute ischemic stroke or used as a dietary supplement for its several different mechanisms of biological activities. However, information on the cytochrome P450 (CYP) enzyme-mediated drug metabolism has not been previously studied. The present study was performed to investigate the effects of vinpocetine on CYPs activity, and cocktail method was used, respectively. To evaluate the effects of vinpocetine on the activity of human CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, human liver microsomes were utilized to incubate with the mixed CYPs probe substrates and the target components. The results indicate that vinpocetine exhibited weak inhibitory effect on the CYP2C9, where the IC50 value is 68.96 μM, whereas the IC50 values for CYP3A4, CYP2C19, CYP2D6, and CYP2E1 were all over range of 100 μM, which showed that vinpocetine had no apparent inhibitory effects on these CYPs. In conclusion, the results indicated that drugs metabolized by CYP2C9 coadministrated with vinpocetine may require attention or dose adjustment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

Kong

Song

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Role of vinpocetine in cerebrovascular diseases

Patyar

Prakash

Modi

et al. 2011

Pharmacological Reports

101

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A cerebrovascular accident, or stroke, is defined as the abrupt onset of a neurological deficit, which can be due to ischemia. Cerebral ischemia is caused by a reduction in blood flow that thereby decreases cerebral metabolism. Chronic cerebral hypoperfusion leads to irreversible brain damage and plays an important role in the development of certain types of dementia. Vinpocetine, chemically known as ethyl apovincaminate, is a vinca alkaloid that exhibits cerebral blood-flow enhancing and neuroprotective effects. Non-clinical and clinical studies have suggested multiple mechanisms responsible for the beneficial neuroprotective effects of vinpocetine. As no significant side effects related to vinpocetine treatment have been reported, it is considered to be safe for long-term use. This vasoactive alkaloid is widely marketed as a supplement for vasodilation and as a nootropic for the improvement of memory. The present review focuses on studies investigating the role of vinpocetine in cerebrovascular diseases.

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Lack of pharmacokinetic interaction between vinpocetine and oxazepam.

Abstract: The influence of multiple doses of vinpocetine (10 mg three times daily) on

Cited by 2 publications

References 17 publications

The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

Role of vinpocetine in cerebrovascular diseases

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