Lack of pathogenic involvement of CCL4 and its receptor CCR5 in arthritogenic alphavirus disease
Muddassar Hameed,
Norman A. Solomon,
James Weger-Lucarelli
Abstract:Arthritogenic alphaviruses, including chikungunya virus (CHIKV), Mayaro virus (MAYV), Ross River virus (RRV), and O’nyong nyong virus (ONNV) are emerging and reemerging viruses that cause disease characterized by fever, rash, and incapacitating joint swelling. Alphavirus infection induces robust immune responses in infected hosts, leading to the upregulation of several cytokines and chemokines, including chemokine C ligand 4 (CCL4). CCL4 is a chemoattractant for immune cells such as T cells, natural killer cel… Show more
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