Lack of Necrosis in Dog Liver After Anesthesia With Halothane

Geisler, Philip H.; Pritchard, Walter; Hall, Kenneth D.

doi:10.1097/00132586-196412000-00030

Cited by 3 publications

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“…1958;NORRIS et al 1963), oxytetracycline treatment in combination with one halothane anaesthesia did not cause toxic liver lesions in the present study. Although halothane anaesthesia has been shown to produce fatty changes in experimental animals (JONES et al.…”

Section: Discussionsupporting

confidence: 50%

Renal and Hepatic Toxicity of Methoxyflurane in Combination with Tetracycline or Oxytetracycline Treatment in Rats

Rosenberg

Wahlström

1974

Acta Pharmacologica et Toxicologica

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A hstract: Methoxyflurane and tetracyclincs may cause dose-related renal dysfunction. In the present study rats were treated with oxytetracycline (37.5 and 75 nig/kg/day) o r tetracycline (75 mg/kg/day) intraperitoneally lor four days and one niethoxyfluranc anacsthesia (1 % for 45 minutes) was given on the second day. The combined treatment as well as methoxyflurane anaesthesia alone, caused polyuria, elevated urinary fluoride excretion, increased serum uric acid concentration and SGPT activity. The histological examination showed shrinkage of glomeruli and tubular protein deposits in the kidneys and marked Pat infiltration in the liver of rats treated with the antibiotics and methoxyflurane, while the anaesthetic seemed to cause only slight fatty changes in thc liver. A probable renal tubular lesion caused by methoxyflurane, or its rnetabolitcs, was indicated by the polyuric effect, thc lack of response to injected vasoprcssin and the uric acid rctention while the tetracyclines probably added to the toxic effect mainly through their anti-anabolic action. Oxytetracycline, in combination with one halothane anaesthesia, did not seem to cause hepatotoxicity in the rats.

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Section: Discussionsupporting

confidence: 50%

Renal and Hepatic Toxicity of Methoxyflurane in Combination with Tetracycline or Oxytetracycline Treatment in Rats

Rosenberg

Wahlström

1974

Acta Pharmacologica et Toxicologica

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“…It has been concluded that halothane is not necrogenic in experimental animals (NORRIS et al 1963;BLOXAM 1967) as are e. g. chloroform and carbon tetrachloride, and the slight hepatic damage sometimes seen is probably due to hepatic hypoxia (GALINMI et al 1966). Administration of the anaesthetic directly into the stomach of mice caused only fatty changes and so did multiple exposures (JONES et al 1958).…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity of Halothane Metabolites in Vivo and Inhibition of Fibroblast Growth in Vitro

Rosenberg

Wahlström

1971

Acta Pharmacologica et Toxicologica

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Following single intraperitoneal doses the halothane metabolites, trifluoroethanol (TFE) and trifluoroacetaldehyde hydrate (TFAIH), produced a marked dose-dependent accumulation of fat in mouse liver, the maximal effect occuring at about 24 hours after administration. Slight fatty changes already occurred with non-lethal doses, but repeated administration did not, however, cause necrosis of the liver cells. Electron microscopy suggested that part of the fat was composed of phospholipids, which are known to accumulate during energy loss. The glycogen granules almost completely disappeared in the liver, this being also confirmed by chemical determination. Trifluoroacetic acid (TFAA) not only caused slight fat accumulation, but also an increase in liver glycogen. In human fibroblast cell cultures TFAIH, even in small concentrations, and TFAA in high concentrations, inhibited cell growth. TFE did not affect the growth of the fibroblasts, probably because no enzymatic system is available in these cells to metabolize TFE to the toxic aldehyde. Two mechanisms may be responsible for the hepatotoxicity of TFE and TFAIH: a) formation of phospholipids due to energy requirement and b) accumulation of liver triglycerides due to blocking of e. g. transport enzymes.

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“…"Ετεροι έρευνηταί (Virtue, Payne et al)52 , χορηγήσαντες τό χαλοθάνιον εις κύνας και είς άναισθητικάς πυκνότητας, ούδεμίαν άξιόλογον βλάβην του ηπατικού κυττάρου διεπίστωσαν έν συγκρίσει προς το χλωροφόρμιον. 'Αρνητικά ήσαν επίσης τά αποτελέσματα τών Norris, Geisler et Al35 επί κυνών. Οί Stephen, MargOlis et Al 48 είς πειράματα γενόμενα επί κυ νών καί πιθήκων παραδέχονται οτι τό χαλοθάνιον είναι πλέον ήπα τοτοξικόν τοΰ αιθέρος αλλά κατά πολύ όλιγώτερον τοξικόν τοΰ CHC1 3 -Ai παρατηρηθεΐσαι βλάβαι μετά χρονίαν εκθεσιν τών ζώων συνίσταντο είς λιπώδη διήθησιν περί τάς κεντρικάς περιοχάς τών ηπατικών λοβίων καί είς έλάττωσιν τοΰ γλυκογόνου.…”

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Συγκριτικαι Ερευναι Επι Της Ηπατοτοξικης Ενεργειας Του Τετραχλωρανθρακος Και Του Χαλοθανιου Επι Διαφορων Ζωων

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Lack of Necrosis in Dog Liver After Anesthesia With Halothane

Cited by 3 publications

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Renal and Hepatic Toxicity of Methoxyflurane in Combination with Tetracycline or Oxytetracycline Treatment in Rats

Renal and Hepatic Toxicity of Methoxyflurane in Combination with Tetracycline or Oxytetracycline Treatment in Rats

Hepatotoxicity of Halothane Metabolites in Vivo and Inhibition of Fibroblast Growth in Vitro

Συγκριτικαι Ερευναι Επι Της Ηπατοτοξικης Ενεργειας Του Τετραχλωρανθρακος Και Του Χαλοθανιου Επι Διαφορων Ζωων

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